Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling

Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance

(2019) Nicholas Waglechner et al.   Nature Microbiology

Deletion of the cell wall peptidoglycan hydrolase gene cwlO or lytE severely impairs transformation efficiency in Bacillus subtilis

(2018) Tai-Yen Liu et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

(2018) Bradley M. Hover et al.   Nature Microbiology

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

(2018) Yan Yan et al.   NATURE

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

(2018) James Peek et al.   Nature Communications

Hydrolysis of peptidoglycan is modulated by amidation of meso -diaminopimelic acid and Mg2+ in B acillus subtilis

(2017) Alex Dajkovic et al.   MOLECULAR MICROBIOLOGY

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster

(2017) Behnam Nazari et al.   MedChemComm

New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions

(2017) Daniel Pletzer et al.   mBio

Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome

(2017) Austin Yan et al.   ACS Infectious Diseases

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis

(2017) Byoung-Mo Koo et al.   Cell Systems

Tafuketide, a phylogeny-guided discovery of a new polyketide from Talaromyces funiculosus Salicorn 58

(2016) Jia Guo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The novel 2016 WHONeisseria gonorrhoeaereference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization

(2016) Magnus Unemo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bulgecin A as a β-lactam enhancer for carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Acinetobacter baumannii clinical isolates containing various resistance mechanisms

(2016) Skalweit et al.   Drug Design Development and Therapy

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

Complestatin Exerts Antibacterial Activity by the Inhibition of Fatty Acid Synthesis

(2015) Yun-Ju Kwon et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism

(2015) Melanie Gonsior et al.   CHEMBIOCHEM

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

(2015) Kristina Haslinger et al.   NATURE

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Arixanthomycins A–C: Phylogeny-Guided Discovery of Biologically Active eDNA-Derived Pentangular Polyphenols

(2014) Hahk-Soo Kang et al.   ACS Chemical Biology

Discovery of Novel Cell Wall-Active Compounds Using PywaC, a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis

(2014) T. L. Czarny et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Something old, something new: revisiting natural products in antibiotic drug discovery

(2014) Gerard D. Wright   CANADIAN JOURNAL OF MICROBIOLOGY

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

Synthesis of fluorescent D-amino acids and their use for probing peptidoglycan synthesis and bacterial growth in situ

(2014) Erkin Kuru et al.   Nature Protocols

Coordinating Bacterial Cell Division with Nutrient Availability: a Role for Glycolysis

(2014) L. G. Monahan et al.   mBio

Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system

(2014) Magda Luciana Atilano et al.   eLife

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

FtsEX is required for CwlO peptidoglycan hydrolase activity during cell wall elongation inBacillus subtilis

(2013) Jeffrey Meisner et al.   MOLECULAR MICROBIOLOGY

Differentiated roles for MreB-actin isologues and autolytic enzymes inBacillus subtilismorphogenesis

(2013) Patricia Domínguez-Cuevas et al.   MOLECULAR MICROBIOLOGY

Identifying producers of antibacterial compounds by screening for antibiotic resistance

(2013) Maulik N Thaker et al.   NATURE BIOTECHNOLOGY

The biofilm formation defect of aBacillus subtilisflotillin-defective mutant involves the protease FtsH

(2012) Ana Yepes et al.   MOLECULAR MICROBIOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

A Novel Factor Controlling Bistability in Bacillus subtilis: the YmdB Protein Affects Flagellin Expression and Biofilm Formation

(2011) C. Diethmaier et al.   JOURNAL OF BACTERIOLOGY

Synthesis and Stereochemical Determination of Complestatin A and B (Neuroprotectin A and B)

(2011) Steven P. Breazzano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial Peptidoglycan-Degrading Enzymes and Their Impact on Host Muropeptide Detection

(2008) Jessica Humann et al.   Journal of Innate Immunity