Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

(2018) Elizabeth I. Parkinson et al.   ACS Chemical Biology

Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species

(2018) Martina Adamek et al.   BMC GENOMICS

Comparison of anthracyclines used for induction chemotherapy in patients with FLT3 -ITD-mutated acute myeloid leukemia

(2018) Eun-Ji Choi et al.   LEUKEMIA RESEARCH

High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries

(2018) Chirag Jain et al.   Nature Communications

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Discovery of the leinamycin family of natural products by mining actinobacterial genomes

(2017) Guohui Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral Gene Transfer Dynamics in the Ancient Bacterial Genus Streptomyces

(2017) Bradon R. McDonald et al.   mBio

Genomic characterization of a new endophytic Streptomyces kebangsaanensis identifies biosynthetic pathway gene clusters for novel phenazine antibiotic production

(2017) Juwairiah Remali et al.   PeerJ

Multiple Streptomyces species with distinct secondary metabolomes have identical 16S rRNA gene sequences

(2017) Sanjay Antony-Babu et al.   Scientific Reports

Contributions of ancestral inter-species recombination to the genetic diversity of extant Streptomyces lineages

(2016) Cheryl P Andam et al.   ISME Journal

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade

(2015) Kelley A. Gallagher et al.   BMC GENOMICS

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

(2015) Kou-San Ju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pan-genome as a shared genomic resource: mutual cheating, cooperation and the black queen hypothesis

(2015) Matthew S. Fullmer et al.   Frontiers in Microbiology

Strain-Level Diversity of Secondary Metabolism in Streptomyces albus

(2015) Ryan F. Seipke   PLoS One

High Doses of Daunorubicin during Induction Therapy of Newly Diagnosed Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis of Prospective Clinical Trials

(2015) Qiang Gong et al.   PLoS One

Prokka: rapid prokaryotic genome annotation

(2014) T. Seemann   BIOINFORMATICS

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

A roadmap for natural product discovery based on large-scale genomics and metabolomics

(2014) James R Doroghazi et al.   Nature Chemical Biology

Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora

(2014) N. Ziemert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

(2013) James R Doroghazi et al.   BMC GENOMICS

ATP Synthase: A Molecular Therapeutic Drug Target for Antimicrobial and Antitumor Peptides

(2013) Zulfiqar Ahmad et al.   CURRENT MEDICINAL CHEMISTRY

Pharmaceutically active secondary metabolites of marine actinobacteria

(2013) Panchanathan Manivasagan et al.   MICROBIOLOGICAL RESEARCH

Antibiotics produced by Streptomyces

(2012) Rudi Emerson de Lima Procópio et al.   Brazilian Journal of Infectious Diseases

Current treatment of acute myeloid leukemia

(2012) Gail J. Roboz   CURRENT OPINION IN ONCOLOGY

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters

(2012) Natsuko Ichikawa et al.   NUCLEIC ACIDS RESEARCH

The Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene Loss

(2012) J. J. Morris et al.   mBio

Ribosomal and protein coding gene based multigene phylogeny on the family Streptomycetaceae

(2011) Ji-Hye Han et al.   SYSTEMATIC AND APPLIED MICROBIOLOGY

Solving the Problem: Genome Annotation Standards before the Data Deluge

(2011) William Klimke et al.   Standards in Genomic Sciences

Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891: Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation

(2010) Fumitaka Kudo et al.   CHEMBIOCHEM

Widespread homologous recombination within and between Streptomyces species

(2010) James R Doroghazi et al.   ISME Journal

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring

(2010) Johannes Kroiss et al.   Nature Chemical Biology

Re-Annotation Is an Essential Step in Systems Biology Modeling of Functional Genomics Data

(2010) Bart H. J. van den Berg et al.   PLoS One

Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi

(2008) Nora Khaldi et al.   GENOME BIOLOGY