Deficiency of a Lipid Droplet Protein, Perilipin 5, Suppresses Myocardial Lipid Accumulation, Thereby Preventing Type 1 Diabetes-Induced Heart Malfunction

Myocardial Adipose Triglyceride Lipase Overexpression Protects Diabetic Mice From the Development of Lipotoxic Cardiomyopathy

(2013) T. Pulinilkunnil et al.   DIABETES

Functional Cardiac Lipolysis in Mice Critically Depends on Comparative Gene Identification-58

(2013) Kathrin A. Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction

(2013) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

(2013) Nina M. Pollak et al.   JOURNAL OF LIPID RESEARCH

Lipid Metabolism and Toxicity in the Heart

(2012) Ira J. Goldberg et al.   Cell Metabolism

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

(2012) Emilio P. Mottillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice

(2012) Li Liu et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial dysfunction in diabetic cardiomyopathy

(2011) Jennifer G. Duncan   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lipotoxicity in type 2 diabetic cardiomyopathy

(2011) Tineke van de Weijer et al.   CARDIOVASCULAR RESEARCH

p53 Promotes Cardiac Dysfunction in Diabetic Mellitus Caused by Excessive Mitochondrial Respiration-Mediated Reactive Oxygen Species Generation and Lipid Accumulation

(2011) Hideo Nakamura et al.   Circulation-Heart Failure

PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfuntion in rats with streptozotocin-induced diabetes

(2011) Yanan Liu et al.   CLINICAL SCIENCE

Inhibition of NADPH oxidase alleviates experimental diabetes-induced myocardial contractile dysfunction

(2011) N. D. Roe et al.   DIABETES OBESITY & METABOLISM

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Thematic Review Series: Lipid droplet storage and metabolism: from yeast to man: Fig. 1.

(2011) Karen Reue   JOURNAL OF LIPID RESEARCH

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction

(2011) P. C. Kienesberger et al.   MOLECULAR AND CELLULAR BIOLOGY

Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy

(2011) J. M. Ellis et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversal of redox-dependent inhibition of diacylglycerol kinase by antioxidants in mesangial cells exposed to high glucose

(2011) Daisuke� Koya   Molecular Medicine Reports

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Mitochondria in the diabetic heart

(2010) H. Bugger et al.   CARDIOVASCULAR RESEARCH

Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes

(2010) Jianmin Li et al.   DIABETES

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

(2010) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

(2009) Perry E. Bickel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia

(2009) E. Shen et al.   DIABETES

Rodent models of diabetic cardiomyopathy

(2009) H. Bugger et al.   Disease Models & Mechanisms

DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity

(2009) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins: TABLE 1.

(2009) Alan R. Kimmel et al.   JOURNAL OF LIPID RESEARCH

Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice

(2008) Masami Ueno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3

(2008) H. Bugger et al.   DIABETES

Superoxide and Respiratory Coupling in Mitochondria of Insulin-Deficient Diabetic Rats

(2008) Judith A. Herlein et al.   ENDOCRINOLOGY

Lipid activation of protein kinases

(2008) Alexandra C. Newton   JOURNAL OF LIPID RESEARCH

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

(2008) Tae-Sik Park et al.   JOURNAL OF LIPID RESEARCH

Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

(2008) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY