19F NMR as a tool in chemical biology

Perfluoro-tert-Butyl Hydroxyprolines as Sensitive, Conformationally Responsive Molecular Probes: Detection of Protein Kinase Activity by 19F NMR

(2020) Caitlin M. Tressler et al.   ACS Chemical Biology

An Engineered E. coli Strain for Direct in Vivo Fluorination

(2020) Konstantinos Markakis et al.   CHEMBIOCHEM

Rapid Quantification of Protein-Ligand Binding via 19F NMR Lineshape Analysis

(2020) Samantha S. Stadmiller et al.   BIOPHYSICAL JOURNAL

Fluorine biocatalysis

(2020) Linrui Wu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fluorine NMR functional screening: from purified enzymes to human intact living cells

(2020) Claudio Dalvit et al.   JOURNAL OF BIOMOLECULAR NMR

The precious fluorine on the ring: fluorine NMR for biological systems

(2020) Andras Boeszoermenyi et al.   JOURNAL OF BIOMOLECULAR NMR

Identification of 5-Fluoro-5-Deoxy-Ribulose as a Shunt Fluorometabolite in Streptomyces sp. MA37

(2020) Linrui Wu et al.   Biomolecules

Hybrid-type and two-tetrad antiparallel telomere DNA G-quadruplex structures in living human cells

(2019) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

19F Paramagnetic Relaxation-Based NMR for Quaternary Structural Restraints of Ion Channels

(2019) Vasyl Bondarenko et al.   ACS Chemical Biology

19F NMR tagging and PRE‐based conformational analysis of intrinsically disordered protein complexes

(2019) Mate Somlyay et al.   CHEMBIOCHEM

A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer

(2019) Fabrizio Pertusati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biodegradation of pentafluorosulfanyl-substituted aminophenol in Pseudomonas spp.

(2018) Marta Saccomanno et al.   BIODEGRADATION

Synthesis of pentafluorosulfanyl (SF 5 ) containing aromatic amino acids

(2018) Lucas Grigolato et al.   JOURNAL OF FLUORINE CHEMISTRY

Cyhalothrin biodegradation in Cunninghamella elegans

(2018) William Palmer-Brown et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects

(2018) Claudio Dalvit et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pentafluorosulfanyl-containing Triclocarban Analogs with Potent Antimicrobial Activity

(2018) Eugènia Pujol et al.   MOLECULES

In-Cell NMR Spectroscopy of Intrinsically Disordered Proteins

(2018) Nicholas Sciolino et al.   PROTEOMICS

Protein 19F-labeling using transglutaminase for the NMR study of intermolecular interactions

(2017) Yoshikazu Hattori et al.   JOURNAL OF BIOMOLECULAR NMR

Strategic incorporation of fluorine into taxoid anticancer agents for medicinal chemistry and chemical biology studies

(2017) Iwao Ojima   JOURNAL OF FLUORINE CHEMISTRY

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

(2017) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

The application of perfluoroheteroaromatic reagents in the preparation of modified peptide systems

(2017) Diana Gimenez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Simple and Sensitive 19 F NMR Approach for Studying the Interaction of RNA G-Quadruplex with Ligand Molecule and Protein

(2017) Hong-Liang Bao et al.   ChemistrySelect

Protein-Observed Fluorine NMR Is a Complementary Ligand Discovery Method to 1H CPMG Ligand-Observed NMR

(2016) Andrew K. Urick et al.   ACS Chemical Biology

Fluorine nuclear magnetic resonance-based assay in living mammalian cells

(2016) Marina Veronesi et al.   ANALYTICAL BIOCHEMISTRY

Microbial degradation of fluorinated drugs: biochemical pathways, impacts on the environment and potential applications

(2016) Cormac D. Murphy   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Current strategies for protein production and purification enabling membrane protein structural biology

(2016) Aditya Pandey et al.   Biochemistry and Cell Biology

Synthesis of Perfluoro-tert-butyl Tyrosine, for Application in 19F NMR, via a Diazonium-Coupling Reaction

(2016) Caitlin M. Tressler et al.   ORGANIC LETTERS

Biotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans

(2016) William Palmer-Brown et al.   XENOBIOTICA

Combined ligand-observe 19F and protein-observe 15N,1H-HSQC NMR suggests phenylalanine as the key Δ-somatostatin residue recognized by human protein disulfide isomerase

(2016) Kirsty L. Richards et al.   Scientific Reports

Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

(2015) Hiroshi NONAKA et al.   ANALYTICAL SCIENCES

19 F Paramagnetic Relaxation Enhancement: A Valuable Tool for Distance Measurements in Proteins

(2015) Elena Matei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Biosynthesis of the Fluorinated Natural Product Nucleocidin inStreptomyces calvusIs Dependent on thebldA-Specified Leu-tRNAUUAMolecule

(2015) Xi Ming Zhu et al.   CHEMBIOCHEM

Role of TERRA in the Regulation of Telomere Length

(2015) Caiqin Wang et al.   International Journal of Biological Sciences

A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in 19F NMR studies of proteins

(2015) Libin Ye et al.   JOURNAL OF BIOMOLECULAR NMR

2′-O-[(4-CF3-triazol-1-yl)methyl] Uridine – A Sensitive 19F NMR Sensor for the Detection of RNA Secondary Structures

(2015) Lotta Granqvist et al.   JOURNAL OF ORGANIC CHEMISTRY

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo

(2015) Kyotaro Hirashima et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid

(2015) Long Ma et al.   Chemical Science

Using 19F NMR to Probe Biological Interactions of Proteins and Peptides

(2014) E. Neil G. Marsh et al.   ACS Chemical Biology

Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis

(2014) Neil K. O’Connor et al.   AMINO ACIDS

19F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction

(2014) Kevin J. Bruemmer et al.   CHEMICAL COMMUNICATIONS

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

An amino acid depleted cell-free protein synthesis system for the incorporation of non-canonical amino acid analogs into proteins

(2014) Amrita Singh-Blom et al.   JOURNAL OF BIOTECHNOLOGY

(2S,4R)- and (2S,4S)-Perfluoro-tert-butyl 4-Hydroxyproline: Two Conformationally Distinct Proline Amino Acids for Sensitive Application in 19F NMR

(2014) Caitlin M. Tressler et al.   JOURNAL OF ORGANIC CHEMISTRY

Single 19F Probe for Simultaneous Detection of Multiple Metal Ions Using miCEST MRI

(2014) Amnon Bar-Shir et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

(2014) Sheng Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

19F NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus

(2014) James M. Aramini et al.   STRUCTURE

Magic-Angle-Spinning NMR Techniques for Measuring Long-Range Distances in Biological Macromolecules

(2013) Mei Hong et al.   ACCOUNTS OF CHEMICAL RESEARCH

19F NMR Studies of a Desolvated Near-Native Protein Folding Intermediate

(2013) Julianne L. Kitevski-LeBlanc et al.   BIOCHEMISTRY

Resolution of Oligomeric Species during the Aggregation of Aβ1–40 Using 19F NMR

(2013) Yuta Suzuki et al.   BIOCHEMISTRY

Fluorine NMR reporter for phosphate anions

(2013) Haiying Gan et al.   CHEMICAL COMMUNICATIONS

Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications

(2013) Anna M. Rydzik et al.   CHEMICAL COMMUNICATIONS

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS

(2013) Kentaro Takahama et al.   CHEMISTRY & BIOLOGY

Fluorine NMR-Based Screening on Cell Membrane Extracts

(2013) Marina Veronesi et al.   ChemMedChem

Perfluoro-tert-butyl-homoserine as a sensitive19F NMR reporter for peptide-membrane interactions in solution

(2013) Benjamin C. Buer et al.   JOURNAL OF PEPTIDE SCIENCE

Dynamic Equilibria between Monomeric and Oligomeric Misfolded States of the Mammalian Prion Protein Measured by 19F NMR

(2013) Sacha Thierry Larda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal Ion Sensing Using Ion Chemical Exchange Saturation Transfer 19F Magnetic Resonance Imaging

(2013) Amnon Bar-Shir et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor

(2013) Tae Hun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

19F-MRS/1H-MRI dual-function probe for detection of β-galactosidase activity

(2013) Jian-Xin Yu et al.   Chemical Science

Multiple-Site Labeling of Proteins with Unnatural Amino Acids

(2012) Karin V. Loscha et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2′-SCF3Uridine-A Powerful Label for Probing Structure and Function of RNA by19F NMR Spectroscopy

(2012) Katja Fauster et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer Consumption

(2012) Yuta Suzuki et al.   BIOCHEMISTRY

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

19F MRI Monitoring of Gene Expression in Living Cells through Cell-Surface β-Lactamase Activity

(2012) Hisashi Matsushita et al.   CHEMBIOCHEM

The Synthesis and Characterization of a Pentafluorosulfanylated Peptide

(2012) Dong Sung Lim et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres

(2012) Yan Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of the novel lipopeptide antibiotic trifluorosurfactin via precursor-directed biosynthesis

(2012) Neil K. O’Connor et al.   JOURNAL OF FLUORINE CHEMISTRY

Interaction of α-Synuclein and a Cell Penetrating Fusion Peptide with Higher Eukaryotic Cell Membranes Assessed by 19F NMR

(2012) Imola G. Zigoneanu et al.   MOLECULAR PHARMACEUTICS

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Monitoring Biocatalytic Transformations Mediated by Polyketide Synthase Enzymes in Cell Lysate via Fluorine NMR

(2012) Adrian Keatinge-Clay et al.   SYNLETT

Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems

(2011) Alexander R. Lippert et al.   ACCOUNTS OF CHEMICAL RESEARCH

Choosing membrane mimetics for NMR structural studies of transmembrane proteins

(2011) Dror E. Warschawski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interaction of α-synuclein with vesicles that mimic mitochondrial membranes

(2011) Imola G. Zigoneanu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Development of a Potassium Ion Sensor for19F Magnetic Resonance Chemical Shift Imaging Based on Fluorine-labeled Thrombin Aptamer

(2011) Takashi Sakamoto et al.   CHEMISTRY LETTERS

Dimer Interface of the Effector Domain of Non-structural Protein 1 from Influenza A Virus

(2011) James M. Aramini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, dynamics, and ionization equilibria of the tyrosine residues in Bacillus circulans xylanase

(2011) Simon J. Baturin et al.   JOURNAL OF BIOMOLECULAR NMR

Selective Molecular Recognition in Amyloid Growth and Transmission and Cross-Species Barriers

(2011) Buyong Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

Biotransformation of Flurbiprofen by Cunninghamella Species

(2010) J. Amadio et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Using Fluorine Nuclear Magnetic Resonance To Probe the Interaction of Membrane-Active Peptides with the Lipid Bilayer

(2010) Benjamin C. Buer et al.   BIOCHEMISTRY

Probing the Micelle-Bound Aggregation-Prone State of α-Synuclein with 19F NMR Spectroscopy

(2010) Gui-Fang Wang et al.   CHEMBIOCHEM

Optimizing 19F NMR protein spectroscopy by fractional biosynthetic labeling

(2010) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF BIOMOLECULAR NMR

19F NMR studies of α-synuclein-membrane interactions

(2010) Gui-Fang Wang et al.   PROTEIN SCIENCE

19F NMR Studies of α-Synuclein Conformation and Fibrillation

(2009) Conggang Li et al.   BIOCHEMISTRY

NMR Spectroscopic Investigation of Early Events in IAPP Amyloid Fibril Formation

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

A Genetically Encoded Direct Sensor of Antibody-Antigen Interactions

(2009) Jeremy H. Mills et al.   CHEMBIOCHEM

Position-Dependent Effects of Fluorinated Amino Acids on the Hydrophobic Core Formation of a Heterodimeric Coiled Coil

(2009) Mario Salwiczek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Approaches for the measurement of solvent exposure in proteins by 19F NMR

(2009) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF BIOMOLECULAR NMR

An Enhanced System for Unnatural Amino Acid Mutagenesis in E. coli

(2009) Travis S. Young et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein19F NMR inEscherichia coli

(2009) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19 F NMR spectroscopy

(2009) Barbara Puffer et al.   NUCLEIC ACIDS RESEARCH

Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

(2009) Stephen Moran et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

19F-MAS NMR on Proteorhodopsin: Enhanced Protocol for Site-Specific Labeling for General Application to Membrane Proteins

(2009) Ute A. Hellmich et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

19F NMR applications in chemical biology

(2008) Steven L. Cobb et al.   JOURNAL OF FLUORINE CHEMISTRY

19F NMR Spectroscopy for the Analysis of RNA Secondary Structure Populations

(2008) Dagmar Graber et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY