The precious fluorine on the ring: fluorine NMR for biological systems

Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR

(2020) Yuji Tokunaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes

(2020) Mikolaj Chrominski et al.   JOURNAL OF ORGANIC CHEMISTRY

Expression, purification, and functional reconstitution of 19F-labeled cytochrome b5 in peptide nanodiscs for NMR studies

(2020) Jia Bai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Fluorine NMR functional screening: from purified enzymes to human intact living cells

(2020) Claudio Dalvit et al.   JOURNAL OF BIOMOLECULAR NMR

A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle

(2020) Gili Abramov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aromatic 19 F– 13 C TROSY—[ 19 F, 13 C]‐Pyrimidine Labeling for NMR Spectroscopy of RNA

(2020) Felix Nußbaumer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics

(2019) Andras Boeszoermenyi et al.   NATURE METHODS

19F Dynamic Nuclear Polarization at Fast Magic Angle Spinning for NMR of HIV-1 Capsid Protein Assemblies

(2019) Manman Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine‐Containing Drugs Approved by the FDA in 2018

(2019) Haibo Mei et al.   CHEMISTRY-A EUROPEAN JOURNAL

Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis

(2019) Yaroslav Nikolaev et al.   NATURE METHODS

More than Proton Detection ‐ New avenues for NMR of RNA

(2019) Robbin Schnieders et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay

(2019) Yann Ayotte et al.   JOURNAL OF MEDICINAL CHEMISTRY

SAR by (Protein-Observed) 19F NMR

(2019) Anand Divakaran et al.   ACCOUNTS OF CHEMICAL RESEARCH

2-Fluorotyrosine is a valuable but understudied amino acid for protein-observed 19F NMR

(2019) Peter D. Ycas et al.   JOURNAL OF BIOMOLECULAR NMR

Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains

(2019) Jorden A. Johnson et al.   ACS Medicinal Chemistry Letters

Automatic structure-based NMR methyl resonance assignment in large proteins

(2019) Iva Pritišanac et al.   Nature Communications

Unveiling invisible protein states with NMR spectroscopy

(2019) T Reid Alderson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Lipoprotein Drug Delivery Vehicles for Cancer: Rationale and Reason

(2019) Jaideep Chaudhary et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Production of isotope-labeled proteins in insect cells for NMR

(2018) Bastian Franke et al.   JOURNAL OF BIOMOLECULAR NMR

Fast Magic Angle Spinning ¹⁹F NMR of HIV-1 Capsid Protein Assemblies

(2018) Mingzhang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Determination of Long-Range Distances by Fast Magic-Angle-Spinning Radiofrequency-Driven 19F–19F Dipolar Recoupling NMR

(2018) Matthias Roos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects

(2018) Claudio Dalvit et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fuzziness enables context dependence of protein interactions

(2017) Marton Miskei et al.   FEBS LETTERS

Simultaneous determination of fast and slow dynamics in molecules using extreme CPMG relaxation dispersion experiments

(2017) Jithender G. Reddy et al.   JOURNAL OF BIOMOLECULAR NMR

Rapid convergence of optimal control in NMR using numerically-constructed toggling frames

(2017) Paul Coote et al.   JOURNAL OF MAGNETIC RESONANCE

Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory

(2017) Iva Pritišanac et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

(2017) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

Synthesis and biological applications of fluoro-modified nucleic acids

(2017) Fengmin Guo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The role of dimer asymmetry and protomer dynamics in enzyme catalysis

(2017) Tae Hun Kim et al.   SCIENCE

Kinetics of the Antibody Recognition Site in the Third IgG-Binding Domain of Protein G

(2016) Supriya Pratihar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Views of Functionally Dynamic Proteins by Solution NMR Spectroscopy

(2016) Lewis E. Kay   JOURNAL OF MOLECULAR BIOLOGY

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

(2016) A. J. Venkatakrishnan et al.   NATURE

The development of cryo-EM into a mainstream structural biology technique

(2016) Eva Nogales   NATURE METHODS

Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells

(2016) Letizia Barbieri et al.   Nature Protocols

Binding interaction of atorvastatin with bovine serum albumin: Spectroscopic methods and molecular docking

(2016) Qi Wang et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Two-Dimensional NMR Lineshape Analysis

(2016) Christopher A. Waudby et al.   Scientific Reports

Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules

(2015) Andrew K. Urick et al.   ACS Chemical Biology

Affinity Screening Using Competitive Binding with Fluorine-19 Hyperpolarized Ligands

(2015) Yaewon Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

19F-labeling of the adenine H2-site to study large RNAs by NMR spectroscopy

(2015) F. Sochor et al.   JOURNAL OF BIOMOLECULAR NMR

Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY

(2015) Alexander G. Milbradt et al.   JOURNAL OF BIOMOLECULAR NMR

Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery

(2015) Keith E. Arntson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

(2015) Fan Yang et al.   Nature Communications

Population Shuffling of Protein Conformations

(2014) Colin A. Smith et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Serum albumin promotes ATP-binding cassette transporter-dependent sterol uptake in yeast

(2014) Magdalena Marek et al.   FEMS YEAST RESEARCH

Interactive Association of Drugs Binding to Human Serum Albumin

(2014) Feng Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

β2-Adrenergic Receptor Activation by Agonists Studied with19F NMR Spectroscopy

(2013) Reto Horst et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Correspondence of Fatty Acid and Drug Binding Sites on Human Serum Albumin: A Two-Dimensional Nuclear Magnetic Resonance Study

(2013) Eileen S. Krenzel et al.   BIOCHEMISTRY

Structural Principles of RNA Catalysis in a 2′–5′ Lariat-Forming Ribozyme

(2013) Teresa Carlomagno et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor

(2013) Tae Hun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A 2D 13C-CEST experiment for studying slowly exchanging protein systems using methyl probes: an application to protein folding

(2012) Guillaume Bouvignies et al.   JOURNAL OF BIOMOLECULAR NMR

Exceeding the limit of dynamics studies on biomolecules using high spin-lock field strengths with a cryogenically cooled probehead

(2012) David Ban et al.   JOURNAL OF MAGNETIC RESONANCE

Comprehensive multiphase NMR spectroscopy: Basic experimental approaches to differentiate phases in heterogeneous samples

(2012) Denis Courtier-Murias et al.   JOURNAL OF MAGNETIC RESONANCE

Domain Swapping Proceeds via Complete Unfolding: A 19F- and 1H-NMR Study of the Cyanovirin-N Protein

(2012) Lin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation

(2012) Pramodh Vallurupalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

Current applications of 19F NMR to studies of protein structure and dynamics

(2011) Julianne L. Kitevski-LeBlanc et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Optimizing 19F NMR protein spectroscopy by fractional biosynthetic labeling

(2010) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF BIOMOLECULAR NMR

Approaches to the assignment of 19F resonances from 3-fluorophenylalanine labeled calmodulin using solution state NMR

(2010) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF BIOMOLECULAR NMR

Characterization of RNA Invasion by19F NMR Spectroscopy

(2010) Anu Kiviniemi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential stability of 2′F-ANA•RNA and ANA•RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility

(2010) Jonathan K. Watts et al.   NUCLEIC ACIDS RESEARCH

Approaches for the measurement of solvent exposure in proteins by 19F NMR

(2009) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF BIOMOLECULAR NMR

Study of the interaction between fluoxetine hydrochloride and bovine serum albumin in the imitated physiological conditions by multi-spectroscopic methods

(2009) Umesha Katrahalli et al.   JOURNAL OF LUMINESCENCE

A Mutagenesis-Free Approach to Assignment of19F NMR Resonances in Biosynthetically Labeled Proteins

(2009) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19 F NMR spectroscopy

(2009) Barbara Puffer et al.   NUCLEIC ACIDS RESEARCH

Recent advances in the synthesis of fluorinated nucleosides

(2009) Xiao-Long Qiu et al.   TETRAHEDRON

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TROSY-Based NMR Evidence for a Novel Class of 20S Proteasome Inhibitors†

(2008) Remco Sprangers et al.   BIOCHEMISTRY

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

(2008) Felix Kratz   JOURNAL OF CONTROLLED RELEASE

Fluorinated nucleosides: Synthesis and biological implication

(2008) Peng Liu et al.   JOURNAL OF FLUORINE CHEMISTRY

Solid state 19F NMR parameters of fluorine-labeled amino acids. Part II: Aliphatic substituents

(2007) Stephan L. Grage et al.   JOURNAL OF MAGNETIC RESONANCE

Solid state 19F NMR parameters of fluorine-labeled amino acids. Part I: Aromatic substituents

(2007) Ulrich H.N. Dürr et al.   JOURNAL OF MAGNETIC RESONANCE