Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts
Authors
Keywords
Biopsy, Gene expression, Fibroblasts, Inflammation, Microarrays, Inflammatory diseases, Immune response, Pathogenesis
Journal
PLoS One
Volume 10, Issue 1, Pages e0114017
Publisher
Public Library of Science (PLoS)
Online
2015-01-22
DOI
10.1371/journal.pone.0114017
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Innate immunity in systemic sclerosis pathogenesis
- (2013) Steven O’Reilly CLINICAL SCIENCE
- Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis
- (2013) Monique Hinchcliff et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma
- (2013) Elizabeth E. Gerber et al. NATURE
- Involvement of PDGF in Fibrosis and Scleroderma: Recent Insights from Animal Models and Potential Therapeutic Opportunities
- (2013) Tomoaki Iwayama et al. Current Rheumatology Reports
- Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets
- (2012) Matthew B. Greenblatt et al. AMERICAN JOURNAL OF PATHOLOGY
- Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions
- (2012) Alexis Mathian et al. ANNALS OF THE RHEUMATIC DISEASES
- Tumor necrosis factor
- (2012) Wen-Ming Chu CANCER LETTERS
- IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?
- (2012) Annalisa Camporeale Frontiers in Bioscience-Landmark
- Janus-like effects of type I interferon in autoimmune diseases
- (2012) Robert C. Axtell et al. IMMUNOLOGICAL REVIEWS
- Elevated Serum Levels of Arachidonoyl-lysophosphatidic Acid and Sphingosine 1-Phosphate in Systemic Sclerosis
- (2012) Akira Tokumura et al. International Journal of Medical Sciences
- Intrinsic Gene Expression Subsets of Diffuse Cutaneous Systemic Sclerosis Are Stable in Serial Skin Biopsies
- (2012) Sarah A. Pendergrass et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Immune Regulation by Sphingosine 1-Phosphate and Its Receptors
- (2011) Constantin Bode et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development
- (2011) Lorin E. Olson et al. DEVELOPMENTAL CELL
- Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli
- (2011) Anahita Hamidi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interferons in Autoimmune and Inflammatory Diseases: Regulation and Roles
- (2011) Divaker Choubey et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Stunned Silence: Gene Expression Programs in Human Cells Infected with Monkeypox or Vaccinia Virus
- (2011) Kathleen H. Rubins et al. PLoS One
- Sphingosine 1-Phosphate Induces Differentiation of Mesoangioblasts towards Smooth Muscle. A Role for GATA6
- (2011) Chiara Donati et al. PLoS One
- Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study
- (2011) Tatiana S. Rodríguez-Reyna et al. RHEUMATOLOGY INTERNATIONAL
- Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease
- (2011) Marie-Elise Truchetet et al. ARTHRITIS RESEARCH & THERAPY
- Systemic sclerosis and lupus: Points in an interferon-mediated continuum
- (2010) Shervin Assassi et al. ARTHRITIS AND RHEUMATISM
- Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction
- (2010) Dmitri V. Pechkovsky et al. CLINICAL IMMUNOLOGY
- Recent advances in pulmonary fibrosis: implications for scleroderma
- (2010) Robert J Homer et al. CURRENT OPINION IN RHEUMATOLOGY
- Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis
- (2010) Jun Wei et al. CURRENT OPINION IN RHEUMATOLOGY
- Th17 cells in inflammation
- (2010) Akihiro Kimura et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: Implications for atherosclerosis
- (2010) Xin Q. Brown et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic Sclerosis
- (2010) Giuseppina A. Farina et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype
- (2010) Susan K Mathai et al. LABORATORY INVESTIGATION
- PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis
- (2010) Jun Wei et al. PLoS One
- Serum levels of soluble CD163 in patients with systemic sclerosis
- (2010) Wakana Nakayama et al. RHEUMATOLOGY INTERNATIONAL
- Molecular framework for response to imatinib mesylate in systemic sclerosis
- (2009) Lorinda Chung et al. ARTHRITIS AND RHEUMATISM
- Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis
- (2009) Lorin E. Olson et al. DEVELOPMENTAL CELL
- Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma
- (2009) Nobuyo Higashi-Kuwata et al. EXPERIMENTAL DERMATOLOGY
- Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator
- (2009) Asish K. Ghosh et al. FASEB JOURNAL
- Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
- (2009) S. Brand GUT
- A TGFβ-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity
- (2009) Jennifer L. Sargent et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes
- (2009) Timothy R. D. J. Radstake et al. PLoS One
- Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis
- (2009) Boris Hinz Current Rheumatology Reports
- TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival
- (2008) Anne Gingery et al. EXPERIMENTAL CELL RESEARCH
- Clinical association of serum interleukin-17 levels in systemic sclerosis: Is systemic sclerosis a Th17 disease?
- (2008) Maki Murata et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin
- (2008) Ausra Milano et al. PLoS One
- Role of PDGF in fibrotic diseases and systemic sclerosis
- (2008) M. Trojanowska RHEUMATOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now