Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury

Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery

(2020) Lekha Nair et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution

(2020) Doo Nam Kim et al.   Nature Communications

Long non-coding RNA NEAT1 binds to microRNA-339-5p to increase HOXA1 and alleviate ischemic brain damage in neonatal mice

(2020) Jing Zhao et al.   Molecular Therapy-Nucleic Acids

The role of a lncRNA (TCONS_00044595) in regulating pineal CLOCK expression after neonatal hypoxia–ischemia brain injury

(2020) Hong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and mechanism of the RNA polymerase II transcription machinery

(2020) Allison C. Schier et al.   GENES & DEVELOPMENT

LncRNA SNHG1 protects SH-SY5Y cells from hypoxic injury through miR-140-5p/Bcl-XL axis

(2020) Da-Wei Wang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

LncRNA HOTAIR Participates in Microglia Activation and Inflammatory Factor Release by Regulating the Ubiquitination of MYD88 in Traumatic Brain Injury

(2020) Shiqi Cheng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Stroke

(2020) Bruce C V Campbell et al.   LANCET

An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer

(2020) Roya Amirinejad et al.   Cell and Bioscience

The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions

(2020) Filipp Frank et al.   Cell Reports

Functional Long Non-coding RNAs Evolve from Junk Transcripts

(2020) Alexander F. Palazzo et al.   CELL

The molecular structure of long non-coding RNAs: emerging patterns and functional implications

(2020) Isabel Chillón et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Expression Profiles of Long Non-coding RNA and Messenger RNA in Human Traumatic Brain Injury

(2020) Dabin Ren et al.   Molecular Therapy-Nucleic Acids

Analysis of long non‐coding RNA expression profiles in neonatal rats with hypoxic‐ischemic brain damage

(2019) Han Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

(2019) Zhipeng Xiao et al.   Aging-US

Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway

(2019) Tina Uroda et al.   MOLECULAR CELL

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Secondary Structural Model of Human MALAT1 Reveals Multiple Structure–Function Relationships

(2019) Phillip J. McCown et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance

(2019) Hassan Yousefi et al.   ONCOGENE

Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer

(2019) Zhao Zhang et al.   Nature Communications

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

System level characterization of small molecule drugs and their affected long noncoding RNAs

(2019) Haixiu Yang et al.   Aging-US

LncRNAGAS5 sponges miRNA-221 to promote neurons apoptosis by up-regulated PUMA under hypoxia condition

(2019) Xiao-Bing Zhou et al.   NEUROLOGICAL RESEARCH

GAS5 silencing protects against hypoxia/ischemia-induced neonatal brain injury

(2018) Rui-bin Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway

(2018) Fenghui Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNA-Targeted Therapeutics

(2018) Stanley T. Crooke et al.   Cell Metabolism

Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury

(2018) Niketa A. Patel et al.   Journal of Neuroinflammation

Genetic Influences on Patient Oriented Outcomes in TBI: A Living Systematic Review of Non-APOE Single Nucleotide Polymorphisms

(2018) Frederick Adam Zeiler et al.   JOURNAL OF NEUROTRAUMA

A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans

(2018) Pei-Fang Tsai et al.   MOLECULAR CELL

Towards a complete map of the human long non-coding RNA transcriptome

(2018) Barbara Uszczynska-Ratajczak et al.   NATURE REVIEWS GENETICS

Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic–Ischemic Brain Injury

(2018) Liu Tu et al.   NEUROCHEMICAL RESEARCH

Role of LncRNA MALAT-1 in hypoxia-induced PC12 cell injury via regulating p38MAPK signaling pathway

(2018) Lin Yang et al.   NEUROSCIENCE LETTERS

Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions that may contribute to paraspeckle architecture

(2018) Yizhu Lin et al.   NUCLEIC ACIDS RESEARCH

Long non-coding RNAs in ischemic stroke

(2018) Mei-Hua Bao et al.   Cell Death & Disease

Circulating long noncoding RNA ANRIL downregulation correlates with increased risk, higher disease severity and elevated pro-inflammatory cytokines in patients with acute ischemic stroke

(2018) Lijuan Feng et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF

(2018) En-yao Li et al.   CELL CYCLE

Protective effects of lncRNA H19 silence against hypoxia-induced injury in PC-12 cells by regulating miR-28

(2018) Zhiping Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Traumatic brain injury: sex, gender and intersecting vulnerabilities

(2018) Tatyana Mollayeva et al.   Nature Reviews Neurology

Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis

(2018) Frederick A. Zeiler et al.   Nature Reviews Neurology

Prediction of LncRNA Subcellular Localization with Deep Learning from Sequence Features

(2018) Brian L. Gudenas et al.   Scientific Reports

Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke

(2017) Xuejing Zhang et al.   JOURNAL OF NEUROSCIENCE

Antisense oligonucleotides: the next frontier for treatment of neurological disorders

(2017) Carlo Rinaldi et al.   Nature Reviews Neurology

NONCODEV5: a comprehensive annotation database for long non-coding RNAs

(2017) ShuangSang Fang et al.   NUCLEIC ACIDS RESEARCH

Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1–Dependent M1 Microglial Polarization

(2017) Jue Wang et al.   STROKE

Acute Ischemic Stroke After Moderate to Severe Traumatic Brain Injury

(2017) Robert G. Kowalski et al.   STROKE

Hypoxia induces H19 expression through direct and indirect Hif-1α activity, promoting oncogenic effects in glioblastoma

(2017) Weining Wu et al.   Scientific Reports

Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy

(2017) Jue Wang et al.   Aging and Disease

Altered expression of long non-coding RNA and mRNA in mouse cortex after traumatic brain injury

(2016) Jianjun Zhong et al.   BRAIN RESEARCH

LncRNA-N1LR Enhances Neuroprotection Against Ischemic Stroke Probably by Inhibiting p53 Phosphorylation

(2016) Zhuomin Wu et al.   MOLECULAR NEUROBIOLOGY

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

Schädel-Hirn-Trauma

(2016) K. Hackenberg et al.   NERVENARZT

Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury

(2016) Tanusree Sen et al.   NEUROPHARMACOLOGY

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

(2016) S. John Liu et al.   SCIENCE

Altered Expression of Long Noncoding RNAs in Blood After Ischemic Stroke and Proximity to Putative Stroke Risk Loci

(2016) Cheryl Dykstra-Aiello et al.   STROKE

Long non-coding RNA C2dat1 regulates CaMKIIδ expression to promote neuronal survival through the NF-κB signaling pathway following cerebral ischemia

(2016) Q Xu et al.   Cell Death & Disease

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

(2016) Keisuke Katsushima et al.   Nature Communications

Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing

(2016) C. Voellenkle et al.   Scientific Reports

HOTAIR Forms an Intricate and Modular Secondary Structure

(2015) Srinivas Somarowthu et al.   MOLECULAR CELL

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

Stimulus-specific combinatorial functionality of neuronal c-fos enhancers

(2015) Jae-Yeol Joo et al.   NATURE NEUROSCIENCE

Transcription factor trapping by RNA in gene regulatory elements

(2015) A. A. Sigova et al.   SCIENCE

Microarray Profiling and Co-Expression Network Analysis of LncRNAs and mRNAs in Neonatal Rats Following Hypoxic-ischemic Brain Damage

(2015) Fengyan Zhao et al.   Scientific Reports

Enhancer RNA Facilitates NELF Release from Immediate Early Genes

(2014) Katie Schaukowitch et al.   MOLECULAR CELL

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury

(2014) E M Mitsis et al.   Translational Psychiatry

Long non-coding RNAs: A new frontier in the study of human diseases

(2013) Xuefei Shi et al.   CANCER LETTERS

Hypoxia-Inducible Factor 1 is Essential for Spontaneous Recovery from Traumatic Brain Injury and is a Key Mediator of Heat Acclimation Induced Neuroprotection

(2013) Gali Umschweif et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Long non-coding RNAs: new players in cell differentiation and development

(2013) Alessandro Fatica et al.   NATURE REVIEWS GENETICS

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Novel classes of non-coding RNAs and cancer

(2012) Jiri Sana et al.   Journal of Translational Medicine

Cis-acting noncoding RNAs: friends and foes

(2012) Sònia Guil et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effect of Focal Ischemia on Long Noncoding RNAs

(2012) Ashutosh Dharap et al.   STROKE

Understanding the transcriptome through RNA structure

(2011) Yue Wan et al.   NATURE REVIEWS GENETICS

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Patients With Traumatic Brain Injury

(2011) Yi-Hua Chen et al.   STROKE

Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2

(2010) Mustafa Ark et al.   APOPTOSIS

ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21

(2010) Lesca M. Holdt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury

(2009) Xiyong Fan et al.   BRAIN RESEARCH REVIEWS

Hypoxia-inducible factor-1α signaling in aquaporin upregulation after traumatic brain injury

(2009) Jamie Y. Ding et al.   NEUROSCIENCE LETTERS