Overexpression of Key Sterol Pathway Enzymes in Two Model Marine Diatoms Alters Sterol Profiles in Phaeodactylum tricornutum

Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway

(2020) Carmela Gallo et al.   Scientific Reports

Extrachromosomal Genetic Engineering of the Marine Diatom Phaeodactylum tricornutum Enables the Heterologous Production of Monoterpenoids

(2020) Michele Fabris et al.   ACS Synthetic Biology

Levels of Diatom Minor Sterols Respond to Changes in Temperature and Salinity

(2020) Ana Cristina Jaramillo-Madrid et al.   Journal of Marine Science and Engineering

The unique sterol biosynthesis pathway of three model diatoms consists of a conserved core and diversified endpoints

(2020) Ana Cristina Jaramillo-Madrid et al.   Algal Research-Biomass Biofuels and Bioproducts

Metabolic Engineering Strategies in Diatoms Reveal Unique Phenotypes and Genetic Configurations With Implications for Algal Genetics and Synthetic Biology

(2020) Jestin George et al.   Frontiers in Bioengineering and Biotechnology

Phytosterol biosynthesis and production by diatoms (Bacillariophyceae)

(2019) Ana Cristina Jaramillo-Madrid et al.   PHYTOCHEMISTRY

Upregulating the mevalonate pathway and repressing sterol synthesis in Saccharomyces cerevisiae enhances the production of triterpenes

(2018) Jan Niklas Bröker et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering the unicellular alga Phaeodactylum tricornutum for high-value plant triterpenoid production

(2018) Sarah D'Adamo et al.   PLANT BIOTECHNOLOGY JOURNAL

Screening for Biologically Annotated Drugs That Trigger Triacylglycerol Accumulation in the DiatomPhaeodactylum

(2018) Melissa Conte et al.   PLANT PHYSIOLOGY

HMG-CoA reductase from Camphor Tulsi (Ocimum kilimandscharicum) regulated MVA dependent biosynthesis of diverse terpenoids in homologous and heterologous plant systems

(2018) Shilpi Bansal et al.   Scientific Reports

Co-expression of squalene epoxidases with triterpene cyclases boosts production of triterpenoids in plants and yeast

(2018) Lemeng Dong et al.   METABOLIC ENGINEERING

Loop assembly: a simple and open system for recursive fabrication of DNA circuits

(2018) Bernardo Pollak et al.   NEW PHYTOLOGIST

Isoprenoid biosynthesis in the diatom Haslea ostrearia

(2018) Anastasia Athanasakoglou et al.   NEW PHYTOLOGIST

Terpenoid Metabolic Engineering in Photosynthetic Microorganisms

(2018) Konstantinos Vavitsas et al.   Genes

Re-assembly, quality evaluation, and annotation of 678 microbial eukaryotic reference transcriptomes

(2018) Lisa K Johnson et al.   GigaScience

A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis

(2018) Jacob Pollier et al.   Nature Microbiology

Increased sesqui- and triterpene production by co-expression of HMG-CoA reductase and biotin carboxyl carrier protein in tobacco (Nicotiana benthamiana)

(2018) Ah-Reum Lee et al.   METABOLIC ENGINEERING

Overexpression of the Squalene Epoxidase Gene Alone and in Combination with the 3-Hydroxy-3-methylglutaryl Coenzyme A Gene Increases Ganoderic Acid Production in Ganoderma lingzhi

(2017) De-Huai Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Paleoproterozoic sterol biosynthesis and the rise of oxygen

(2017) David A. Gold et al.   NATURE

Autoinhibitory sterol sulfates mediate programmed cell death in a bloom-forming marine diatom

(2017) Carmela Gallo et al.   Nature Communications

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

(2017) Jialin Wang et al.   Food & Nutrition Research

Plant sterols: Diversity, biosynthesis, and physiological functions

(2016) J. N. Valitova et al.   BIOCHEMISTRY-MOSCOW

Addressing various compartments of the diatom model organism Phaeodactylum tricornutum via sub-cellular marker proteins

(2016) Xiaojuan Liu et al.   Algal Research-Biomass Biofuels and Bioproducts

Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity

(2015) Sara Laranjeira et al.   Molecular Plant

Comprehensive Assessment of Transcriptional Regulation Facilitates Metabolic Engineering of Isoprenoid Accumulation in Arabidopsis

(2015) Iris Lange et al.   PLANT PHYSIOLOGY

Accumulation of Squalene in a Microalga Chlamydomonas reinhardtii by Genetic Modification of Squalene Synthase and Squalene Epoxidase Genes

(2015) Masataka Kajikawa et al.   PLoS One

InterProScan 5: genome-scale protein function classification

(2014) P. Jones et al.   BIOINFORMATICS

LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies

(2014) Rouyanne T. Ras et al.   BRITISH JOURNAL OF NUTRITION

Tracking the sterol biosynthesis pathway of the diatomPhaeodactylum tricornutum

(2014) Michele Fabris et al.   NEW PHYTOLOGIST

Functional Analysis of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Encoding Genes in Triterpene Saponin-Producing Ginseng

(2014) Y.-J. Kim et al.   PLANT PHYSIOLOGY

A New and Improved Host-Independent Plasmid System for RK2-Based Conjugal Transfer

(2014) Trine Aakvik Strand et al.   PLoS One

Species-Specific Expansion and Molecular Evolution of the 3-hydroxy-3-methylglutaryl Coenzyme A Reductase (HMGR) Gene Family in Plants

(2014) Wei Li et al.   PLoS One

Antiinflammatory Effect of Phytosterols in Experimental Murine Colitis Model: Prevention, Induction, Remission Study

(2014) Rita Aldini et al.   PLoS One

The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): Illuminating the Functional Diversity of Eukaryotic Life in the Oceans through Transcriptome Sequencing

(2014) Patrick J. Keeling et al.   PLOS BIOLOGY

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

Squalene epoxidase as a target for manipulation of squalene levels in the yeastSaccharomyces cerevisiae

(2013) Martina Garaiová et al.   FEMS YEAST RESEARCH

High-value products from microalgae—their development and commercialisation

(2013) Michael A. Borowitzka   JOURNAL OF APPLIED PHYCOLOGY

The metabolic blueprint of Phaeodactylum tricornutum reveals a eukaryotic Entner-Doudoroff glycolytic pathway

(2012) Michele Fabris et al.   PLANT JOURNAL

The place of diatoms in the biofuels industry

(2012) Mark Hildebrand et al.   Biofuels-UK

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

The Sterol-sensing Domain (SSD) Directly Mediates Signal-regulated Endoplasmic Reticulum-associated Degradation (ERAD) of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Isozyme Hmg2

(2011) Chandra L. Theesfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comprehensive study of sterols in marine diatoms (Bacillariophyta): Implications for their use as tracers for diatom productivity

(2011) Sebastiaan W. Rampen et al.   LIMNOLOGY AND OCEANOGRAPHY

Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae

(2011) Martin Lohr et al.   PLANT SCIENCE

Regulation of HMG-CoA reductase in mammals and yeast

(2011) John S. Burg et al.   PROGRESS IN LIPID RESEARCH

Characterization of an Endoplasmic Reticulum-associated Silaffin Kinase from the Diatom Thalassiosira pseudonana

(2009) Vonda Sheppard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The life of diatoms in the world's oceans

(2009) E. Virginia Armbrust   NATURE

The Phaeodactylum genome reveals the evolutionary history of diatom genomes

(2008) Chris Bowler et al.   NATURE