Article
Plant Sciences
Elisangela dos Santos, Maicon Matos Leitao, Caren Naomi Aguero Ito, Saulo Euclides Silva-Filho, Arielle Cristina Arena, Francielli Maria de Souza Silva-Comar, Roberto Kenji Nakamura Cuman, Rodrigo Juliano Oliveira, Anelise Samara Nazari Formagio, Candida Aparecida Leite Kassuya
Summary: The leaves of Ocimum kilimandscharicum Gurke are commonly used to treat joint pain, and the study found that extracts from these leaves have anti-inflammatory and analgesic properties that can be used to treat pain and inflammation-related conditions.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Serkan Yigitkan, Abdulselam Ertas, Ramin Ekhteiari Salmas, Mehmet Firat, Ilkay Erdogan Orhan
Summary: This study investigated the HMG-CoA reductase inhibitory potential of extracts from the roots and aerial parts of Salvia multicaulis Vahl. and identified 7-acetoxyhorminone as the most effective inhibitory compound.
Article
Chemistry, Medicinal
Xing-Zi Li, Shi-You Jiang, Guo-Qiang Li, Qian-Ru Jiang, Jue-Wan Li, Chen-Chen Li, Yu-Qin Han, Bao-Liang Song, Xin-Ran Ma, Wei Qi, Wen-Wei Qiu
Summary: A series of novel HMG499 analogs were synthesized and one of the compounds, 29 (QH536), showed potent activity in promoting HMGCR degradation without inducing cholesterol accumulation in cells. Compound 29 also exhibited effects on lowering cholesterol levels and suppressing various related genes, making it a potential candidate for the treatment of CVD and NASH.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Samuel Yesuthason Renald, Raju Balaji, Tanuja, Madasamy Parani
Summary: The chloroplast genome sequence of Camphor Basil (Ocimum kilimandscharicum) was sequenced and characterized for the first time in this study. The genome is 151,741 bp in length, contains 135 predicted genes, and phylogenetic analysis revealed its close relationship with other Ocimum species in the Lamiaceae family.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Agriculture, Dairy & Animal Science
Janaina S. da Silva, Alessandra F. Rosa, Cristina T. Moncau, Barbara Silva-Vignato, Silvana Marina P. Pugine, Mariza P. de Melo, Joao Marcelo D. Sanchez, Marcus Antonio Zanetti
Summary: The effects of different sources and concentrations of selenium on glutathione forms and cholesterol metabolism in beef cattle were investigated in this study. Selenium supplementation can impact cholesterol metabolism by affecting GSH/GSSG ratio, GSH-Px, and HMGCR. The interaction between selenium source and concentration can influence glutathione forms.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Oncology
Verena Korte, Guenther Gademann, Ahmed Gawish, Hans-Joachim Ochel
Summary: This study investigated the antiproliferative effects of simvastatin in combination with ionizing radiation on prostate cancer cells, and found that radiation had a stronger inhibitory effect compared to simvastatin alone. However, the combined application of both modalities had a synergistic effect. Simvastatin exerted its antiproliferative effects by inducing the elevation of HMG-CoA reductase levels.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biology
Nadeem Ullah Wazir, Irfan Amir Khan, Adil Javed, Taous Khan, Abdul Jabbar
Summary: The study assessed the effect of methanolic root extract of Onosma hispidum in hyperlipidemia and associated vascular dysfunction. The results showed that the extract significantly reduced total triglycerides and cholesterol levels in hyperlipidemic rats and improved vascular dysfunction. This suggests that the extract of Onosma hispidum has a good therapeutic effect on hypercholesterolemia and hypertriglyceridemia.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rebecca Faulkner, Youngah Jo
Summary: Cholesterol is an essential component of cellular membranes and lipoproteins, and also serves as a precursor for steroid hormones and bile acids. The mevalonate pathway, in addition to producing cholesterol, generates nonsterol isoprenoids that are crucial for cell survival. The regulation of the rate-limiting enzyme in the mevalonate pathway, HMGCR, is controlled by a complex feedback regulatory system. Sterols and nonsterol isoprenoids play important roles in transcriptional and post-translational regulation of HMGCR.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Clinical Neurology
Hyo Jeong Lee, Kyungdo Han, Yong Wook Kim, Seung Nam Yang, Seo Yeon Yoon
Summary: This study aimed to examine the association between lipid levels and the risk of Parkinson's disease (PD) in individuals with diabetes mellitus (DM) and evaluate whether the association changes with the use of statins. The results showed an inverse association between lipid levels and PD development in patients with DM, which was influenced by statin use.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Jonas Ghouse, Gustav Ahlberg, Anne Guldhammer Skov, Henning Bundgaard, Morten S. Olesen
Summary: Inhibition of the HMGCR gene was found to be associated with an increased risk of cataract, suggesting that long-term statin treatment may lead to cataract formation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Hematology
Pengcheng Xu, Yajing Zhao, Tianshu Yu, Yafei Yu, Xiaofei Ni, Haoyi Wang, Lu Sun, Panpan Han, Lingjun Wang, Tao Sun, Xinguang Liu, Hai Zhou, Jun Peng, Ming Hou, Yu Hou, Miao Xu
Summary: The study investigated the therapeutic effect of atorvastatin on immune thrombocytopenia (ITP). It was found that atorvastatin could inhibit the excessive activation of CD4(+) T cells and restore their function, potentially serving as a potential treatment option for ITP.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Chemistry, Medicinal
Ngoc Tan Cao, Ngoc Anh Nguyen, Chan Mi Park, Gun Su Cha, Ki Deok Park, Chul-Ho Yun
Summary: Statins inhibit the enzyme HMG-CoA reductase, reducing cholesterol biosynthesis and lowering the risk of cardiovascular disease. Monacolin J, found in red yeast rice, can be transformed into a new derivative with enhanced HMG-CoA reductase inhibitory activity through specific enzyme catalysis. This discovery may lead to the development of new statin drug candidates through enzymatic and chemical processes.
Article
Cardiac & Cardiovascular Systems
Nicholas B. Alana, William A. Ciurylo, Natalie Hurlock
Summary: This study suggests that moderate and high intensity statin medications may reduce the frequency of DIC in critically ill patients with severe sepsis or septic shock.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Plant Sciences
Sushil Kumar Chaudhary, K. Chandradev Sharma, Sarangthem Indira Devi, Amit Kar, Pardeep Kumar Bhardwaj, Nanaocha Sharma, Ojit Singh Keithellakpam, Pulok K. Mukherjee
Summary: Ficus cunia is used by tribes in India to treat liver disease, ulcer, dysentery, gynecological disorders. This study found that Ficus cunia contains various phenolic compounds with antioxidant, anti-inflammatory, and anti-HMG-CoA reductase potential. The extract of Ficus cunia showed promising antioxidant, anti-inflammatory effects and could lower cholesterol levels.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Multidisciplinary Sciences
Wencui Yin, Reem Al-Wabli, Mohamed W. Attwa, A. F. M. Motiur Rahman, Adnan A. Kadi
Summary: This study detected and characterized simvastatin and its metabolites in various organs and samples of rats using MALDI Orbitrap mass spectrometer. Different sample loading and cell disruption methods were evaluated, and 13 metabolites were detected.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Sandhya Tripathi, Yashdeep Srivastava, Rajender Singh Sangwan, Neelam Singh Sangwan
SCIENTIFIC REPORTS
(2020)
Article
Plant Sciences
Jyoti Singh Jadaun, Amit Kumar Kushwaha, Neelam S. Sangwan, Lokesh Kumar Narnoliya, Smrati Mishra, Rajender Singh Sangwan
PLANT CELL REPORTS
(2020)
Article
Plant Sciences
Sandeep K. Singh, Guru R. Valicherla, Anil K. Bikkasani, Srikanth H. Cheruvu, Zakir Hossain, Isha Taneja, Hafsa Ahmad, Kanumuri S. R. Raju, Neelam S. Sangwan, Shio K. Singh, Anil K. Dwivedi, Mohammad Wahajuddin, Jiaur R. Gayen
Summary: The study aimed to develop a precise method for analyzing Withanone (WN) in rat plasma, and investigate its in-vitro ADME behavior. Results showed that WN exhibited stability and high permeability in simulated gastric and intestinal environments, with high plasma protein binding. CYP phenotyping indicated extensive metabolism by CYP 3A4 and 1A2, though it did not potently inhibit any CYP isoenzymes in rat and human liver microsomes. The findings suggest that WN could be a promising phytochemical for neurological disorders based on its pharmacokinetics and pharmacodynamics.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Lokesh Kumar Narnoliya, Neelam Sangwan, Jyoti Singh Jadaun, Shilpi Bansal, Rajender Singh Sangwan
Summary: This study cloned and characterized the recombinant caffeic acid 3-O-methyltransferase gene from Neem, demonstrating its crucial role in ferulic acid biosynthesis. The heterologous expression of the gene in different plant species provided insights into its biological function in plants, highlighting potential applications in metabolic engineering for the biosynthesis of therapeutically important phytomolecules.
Article
Oncology
Deepti Diwan, Lei Cheng, Zeba Usmani, Minaxi Sharma, Nicola Holden, Nicholas Willoughby, Neelam Sangwan, Rama Raju Baadhe, Chenchen Liu, Vijai Kumar Gupta
Summary: The success of conventional cancer therapeutics is limited by antibiotic resistance and lack of specificity in anti-tumor drugs. Microbial-derived bioactive molecules are offering a new strategic solution by selectively targeting cancer cells. This review provides a comprehensive summary of the anti-carcinogenic properties of these molecules and discusses effective therapeutic applications to minimize systemic side effects.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Surjeet Verma, Chirag N. Patel, Muktesh Chandra
Summary: This study conducted investigation, screening, and identification of potent leads from Withania sps. against SARS-CoV-2, using virtual screening, molecular docking, and molecular dynamics simulations. The study identified several compounds with high binding energy for the M-pro target, as potential candidates for drug development against COVID-19.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2021)
Article
Agricultural Engineering
Bhawana Mishra, Muktesh Chandra, Deepak Pant
Summary: The study evaluated the genetic, antioxidant compound, and metabolite activities of medicinal and aromatic plants with phytoremediation potential. The research demonstrated that these plants possess characteristics related to antioxidants, phytoremediation, and stress tolerance.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Priya Pathak, Prachi Shukla, Jitendra S. Kanshana, Kumaravelu Jagavelu, Neelam S. Sangwan, Anil K. Dwivedi, Madhu Dikshit
Summary: The study aimed to evaluate the vasoprotective potential of NM and its biomarker compound WA using rat aortic rings and EA.hy926 endothelial cells. NM and WA exerted moderate vasorelaxant effect in rat aortic rings, mediated by enhanced eNOS phosphorylation and NO/cGMP pathway. The vasorelaxant property of NM is beneficial for its neuroprotective potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Muktesh Chandra, Shiwani Kushwaha, Bhawana Mishra, Neelam Sangwan
Summary: The essential oil of Ocimum species has been widely used in traditional medicine in India for its pharmacological importance. Recent studies have focused on defining the major genes of phenylpropanoid and terpenoid pathways in Ocimum species. Structural studies revealed significant differences in enzymes of the MVA pathway in two major species of Ocimum, with implications for the regulation of terpenoid biosynthesis.
PLANT GROWTH REGULATION
(2022)
Article
Biochemistry & Molecular Biology
Shama Afroz, Zafar Iqbal Warsi, Kahkashan Khatoon, Neelam S. Sangwan, Feroz Khan, Laiq Ur Rahman
Summary: In this study, a key gene CaHMGS in Centella asiatica was successfully isolated and characterized. The gene showed the highest expression level in the roots and the lowest expression level in the node of the plant. Functional complementation experiment confirmed the functionality of the CaHMGS gene. This study contributes to the enhancement of secondary metabolite production in the plant.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Plant Sciences
Yashdeep Srivastava, Sandhya Tripathi, Bhawana Mishra, Neelam S. Sangwan
Summary: This study cloned and characterized a key enzyme, geranylgeranyl pyrophosphate synthase (WsGGPPS), involved in the terpenoid biosynthetic pathway in Withania somnifera. Overexpression of WsGGPPS resulted in increased levels of gibberellic acid. These findings provide important insights into the regulation of major metabolite biosynthesis in Withania somnifera.
Review
Plant Sciences
Bhawana Mishra, Muktesh Chandra
Summary: Heavy metal pollution is a severe environmental and agricultural issue, and phyto-remediation using aromatic plants as hyperaccumulators shows great promise for sustainable solution. This review identifies Geraniaceae, Poaceae, Lamiaceae, and Asteraceae as suitable families for phytoremediation due to their economic importance and ability to thrive in heavy metal-polluted soils. The strategies and mechanisms of plants like citronella, basil, and lemon grass are analyzed, providing valuable information for future research.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2022)
Review
Biotechnology & Applied Microbiology
Nisha Yadav, Deependra Singh, Manju Rawat, Neelam Sangwan
Summary: This paper discusses the global incidence and prevalence of various types of cancer and explores the potential of natural drugs and nanocarrier systems in cancer treatment. It highlights the promising alternatives offered by specialized metabolites from medicinal plants and emphasizes the importance of phytochemicals in preventing and treating cancer. The paper also suggests that nanoparticles can enhance the stability, solubility, bioavailability, and target specificity of plant products, making them more effective and safe for drug delivery.
Article
Multidisciplinary Sciences
Jyoti Sangwan, Sandhya Tripathi, Nisha Yadav, Yogesh Kumar, Neelam Sangwan
Summary: SARS-nCoV, a rapidly spreading coronavirus, has affected millions of people worldwide. Understanding the genomic information is crucial for controlling its spread. Comparative sequence analysis revealed variations in the sequences coding for different proteins between SARS CoV and SARS nCoV. The S protein coding sequences of SARS CoV showed deletions, insertions, and substitutions in SARS nCoV sequence. The binding interaction pattern of ACE2 receptor protein with SARS-CoV-2 and Omicron variant indicated potential impacts on virulence.
PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY
(2023)