Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress

Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition

(2020) Peipei Peng et al.   FEBS Open Bio

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nutritional Aspects of Spermidine

(2020) Frank Madeo et al.   Annual Review of Nutrition

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

(2020) Maren C. Podszun et al.   Redox Biology

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Suppression of Brown Adipocyte Autophagy Improves Energy Metabolism by Regulating Mitochondrial Turnover

(2019) Donghwan Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes

(2019) Estel Solsona-Vilarrasa et al.   Redox Biology

Medicinal prospects of antioxidants: A review

(2019) Kumari Neha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

(2019) José M. Bravo-San Pedro et al.   Cell Metabolism

Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials

(2019) Moein Askarpour et al.   PHARMACOLOGICAL RESEARCH

Autophagy and Inflammation

(2018) Yu Matsuzawa-Ishimoto et al.   Annual Review of Immunology

Toward Precision Approaches for the Prevention and Treatment of Obesity

(2018) Susan Z. Yanovski et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Carnitine induces autophagy and restores high-fat diet-induced mitochondrial dysfunction

(2018) Jin Woo Choi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting autophagy in obesity: from pathophysiology to management

(2018) Yingmei Zhang et al.   Nature Reviews Endocrinology

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep Apnea: A Possible Link to Oxidative Stress and Cardiovascular Complications

(2018) Slava Berger et al.   Oxidative Medicine and Cellular Longevity

Safety and tolerability of new-generation anti-obesity medications: a narrative review

(2018) Dhiren K Patel et al.   POSTGRADUATE MEDICINE

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

(2018) Yoshinori Takahashi et al.   Nature Communications

Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota

(2018) Weiyao Liao et al.   MOLECULES

Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid

(2018) Phiwayinkosi Dludla et al.   Nutrients

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress

(2017) Jihoon Nah et al.   Cell Death & Disease

Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

(2017) Álvaro F Fernández et al.   Cell Death & Disease

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

(2016) Weiqian Chen et al.   Redox Biology

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects

(2015) Marta Fernández-Galilea et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Organelle-Specific Initiation of Autophagy

(2015) Valentina Sica et al.   MOLECULAR CELL

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

Zinc and autophagy

(2014) Juan P. Liuzzi et al.   BIOMETALS

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Assessment and Lifestyle Management of Patients With Obesity

(2014) Robert F. Kushner et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Overweight and Obesity Epidemic in Developing Countries: A Problem with Diet, Physical Activity, or Socioeconomic Status?

(2014) Trishnee Bhurosy et al.   TheScientificWorldJOURNAL

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers

(2014) Hwan-Woo Park et al.   Nature Communications

New considerations on hormetic response against oxidative stress

(2014) Armando Luna–López et al.   Journal of Cell Communication and Signaling

Reactive Oxygen Species Regulation of Autophagy in Skeletal Muscles

(2013) Mashrur Rahman et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease

(2013) Micheal S Ward et al.   CURRENT OPINION IN PHARMACOLOGY

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

Autophagy Deficiency by Hepatic FIP200 Deletion Uncouples Steatosis From Liver Injury in NAFLD

(2013) Di Ma et al.   MOLECULAR ENDOCRINOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases

(2013) Morihiro Matsuda et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

The interplay between autophagy and ROS in tumorigenesis

(2012) Sameera Kongara et al.   Frontiers in Oncology

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

(2011) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial dysfunction in obesity

(2011) Juan C Bournat et al.   Current Opinion in Endocrinology Diabetes and Obesity

Hydrogen peroxide: a Jekyll and Hyde signalling molecule

(2011) D R Gough et al.   Cell Death & Disease

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

The biological significance of methionine sulfoxide stereochemistry

(2010) Byung Cheon Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Exogenous Antioxidants—Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

(2010) Jaouad Bouayed et al.   Oxidative Medicine and Cellular Longevity

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

As a Matter of Fat

(2009) Rita T. Brookheart et al.   Cell Metabolism

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism