Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies

Effects of vitamin C supplementation on essential hypertension

(2020) Yuanyuan Guan et al.   MEDICINE

Microbiome and pathogen interaction with the immune system

(2020) Michael H. Kogut et al.   POULTRY SCIENCE

Myth Busters: Dietary Supplements and COVID-19

(2020) Kathleen K. Adams et al.   ANNALS OF PHARMACOTHERAPY

Interactions between antiretroviral therapy and complementary and alternative medicine: a narrative review

(2020) C. Bordes et al.   CLINICAL MICROBIOLOGY AND INFECTION

Medications in COVID-19 patients: summarizing the current literature from an orthopaedic perspective

(2020) Si Heng Sharon Tan et al.   INTERNATIONAL ORTHOPAEDICS

Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis

(2020) Mohammed Iddir et al.   Nutrients

On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence

(2020) Jens Lykkesfeldt   Redox Biology

Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?

(2020) Adam F. Feyaerts et al.   NUTRITION

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern?

(2020) Sam Rowe et al.   Nutrients

Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study

(2019) Tae Gun Shin et al.   Journal of Clinical Medicine

Boswellic acid has anti‐inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells

(2019) Manlio Barbarisi et al.   PHYTOTHERAPY RESEARCH

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

(2019) Feng Wang et al.   BMC CANCER

Cardiotoxicity and pro-inflammatory effects of the immune checkpoint inhibitor Pembrolizumab associated to Trastuzumab

(2019) V. Quagliariello et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Relationships between Atherosclerosis and Plasma Antioxidant Micronutrients or Red Blood Cell Polyunsaturated Fatty Acids in People Living with HIV

(2019) Katherine J. P. Schwenger et al.   Nutrients

Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases

(2019) Helen Strongman et al.   LANCET

Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death

(2019) Nadine El Banna et al.   Redox Biology

The Pharmacokinetics of Vitamin C

(2019) Jens Lykkesfeldt et al.   Nutrients

Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials

(2019) Mikee Liugan et al.   Nutrients

Malignant melanoma in HIV: Epidemiology, pathogenesis, and management

(2019) Alessio Facciolà et al.   Dermatologic Therapy

Plasma levels of free fatty acid differ in patients with left ventricular preserved, mid-range, and reduced ejection fraction

(2018) Ning Zhu et al.   BMC Cardiovascular Disorders

The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia

(2018) Huihui Zhao et al.   LEUKEMIA RESEARCH

Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma

(2018) Brianne R. O'Leary et al.   RADIATION RESEARCH

Head and neck squamous cell carcinoma and its correlation with human papillomavirus in people living with HIV: a systematic review

(2018) Manuela Ceccarelli et al.   Oncotarget

Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation

(2018) Yun-Xin Lu et al.   Theranostics

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence

(2018) Margreet C. M. Vissers et al.   Frontiers in Physiology

Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB

(2018) Emmanuel Musisi et al.   African Health Sciences

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

Cardioprotective Effects of Nanoemulsions Loaded with Anti-Inflammatory Nutraceuticals against Doxorubicin-Induced Cardiotoxicity

(2018) Vincenzo Quagliariello et al.   Nutrients

Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge

(2018) Anitra C. Carr et al.   Frontiers in Physiology

HIV-associated psoriasis: Epidemiology, pathogenesis, and management

(2018) Manuela Ceccarelli et al.   Dermatologic Therapy

Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant B-cells to pharmacological ascorbate

(2018) Agnieszka Graczyk-Jarzynka et al.   Redox Biology

Molecular regulation of cellular iron balance

(2017) Stefania Recalcati et al.   IUBMB LIFE

Vitamin C Intake is Inversely Associated with Cardiovascular Mortality in a Cohort of Spanish Graduates: the SUN Project

(2017) Nerea Martín-Calvo et al.   Nutrients

Vitamin C and Immune Function

(2017) Anitra Carr et al.   Nutrients

Orange juice as dietary source of antioxidants for patients with hepatitis C under antiviral therapy

(2017) Danielle Gonçalves et al.   Food & Nutrition Research

High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study

(2017) Kishore Polireddy et al.   Scientific Reports

EFFECTS OF L-ASCORBIC ACID AND ALPHA-TOCOPHEROL ON BIOCHEMICAL PARAMETERS OF SWIMMING-INDUCED OXIDATIVE STRESS IN SERUM OF GUINEA PIGS

(2016) Marija Bursać-Mitrović et al.   African Journal of Traditional Complementary and Alternative Medicines

Dietary supplement interactions with antiretrovirals: a systematic review

(2016) Mohamed A Jalloh et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion

(2016) Yong Seon Choi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of long-term Vitamin C intake on vascular endothelial function in diabetic children and adolescents: A pilot study

(2016) Ghafour Ghaffari et al.   Journal of Research in Medical Sciences

Vitamin C: the known and the unknown and Goldilocks

(2016) SJ Padayatty et al.   ORAL DISEASES

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

Determination of plasma and leukocyte vitamin C concentrations in a randomized, double-blind, placebo-controlled trial with Ester-C®

(2016) Susan H. Mitmesser et al.   SpringerPlus

Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs

(2015) Stine Hasselholt et al.   BRITISH JOURNAL OF NUTRITION

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

(2015) J. Du et al.   CANCER RESEARCH

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy

(2015) Mirelle J.A.J. Huijskens et al.   CYTOTHERAPY

Is There a Role for Oral or Intravenous Ascorbate (Vitamin C) in Treating Patients With Cancer? A Systematic Review

(2015) C. Jacobs et al.   ONCOLOGIST

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

(2015) Mohammed S. Ellulu et al.   Drug Design Development and Therapy

Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following Dietary Supplementation with Vitamin C-Rich SunGold Kiwifruit

(2015) Stephanie Bozonet et al.   Nutrients

Antioxidant Vitamin C Prevents Decline in Endothelial Function during Sitting

(2015) Janet P. Wallace   MEDICAL SCIENCE MONITOR

High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial

(2015) L. John Hoffer et al.   PLoS One

Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with l-ascorbic acid

(2014) Kaitlin H Wade et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effect of vitamin C on endothelial function in health and disease: A systematic review and meta-analysis of randomised controlled trials

(2014) Ammar W. Ashor et al.   ATHEROSCLEROSIS

Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting

(2014) Srinivasan Senthilkumari et al.   EXPERIMENTAL EYE RESEARCH

Dietary Supplement Use Among Patients With Hepatocellular Carcinoma

(2014) Valerie Lee et al.   INTEGRATIVE CANCER THERAPIES

Intravenous Vitamin C and Cancer

(2014) Heidi Fritz et al.   INTEGRATIVE CANCER THERAPIES

In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain

(2014) Ditte Søgaard et al.   NUTRITION RESEARCH

High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

(2014) Y. Ma et al.   Science Translational Medicine

Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression

(2014) Maya Paidi et al.   Nutrients

Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease

(2013) Mandana Amir Shaghaghi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial

(2013) J. L. Welsh et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer

(2013) Christopher M. Stephenson et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

(2013) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Intestinal Dehydroascorbic Acid (DHA) Transport Mediated by the Facilitative Sugar Transporters, GLUT2 and GLUT8

(2013) Christopher P. Corpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

(2013) Anitra Carr et al.   Nutrients

Regulation of Vitamin C Homeostasis during Deficiency

(2013) Maiken Lindblad et al.   Nutrients

Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection

(2013) Yejin Kim et al.   Immune Network

Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials

(2012) Stephen P Juraschek et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin C Promotes Maturation of T-Cells

(2012) Jared Manning et al.   ANTIOXIDANTS & REDOX SIGNALING

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?

(2012) Balz Frei et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells

(2012) Matthias Stadtfeld et al.   NATURE GENETICS

Customized optimization of metabolic pathways by combinatorial transcriptional engineering

(2012) Jing Du et al.   NUCLEIC ACIDS RESEARCH

SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment

(2012) S-W Hong et al.   ONCOGENE

Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer

(2012) Daniel A. Monti et al.   PLoS One

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter

(2011) Lorena Mardones et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Testis-Enriched Histone Demethylase, KDM4D, Regulates Methylation of Histone H3 Lysine 9 During Spermatogenesis in the Mouse but Is Dispensable for Fertility1

(2011) Naoki Iwamori et al.   BIOLOGY OF REPRODUCTION

The Genetics of Vitamin C Loss in Vertebrates

(2011) Guy Drouin et al.   CURRENT GENOMICS

Jarid1b targets genes regulating development and is involved in neural differentiation

(2011) Sandra U Schmitz et al.   EMBO JOURNAL

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

(2011) Michael Graham Espey et al.   FREE RADICAL BIOLOGY AND MEDICINE

High dose of ascorbic acid induces cell death in mesothelioma cells

(2010) Yukitoshi Takemura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

(2010) J. Du et al.   CLINICAL CANCER RESEARCH

Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice

(2010) Christopher P. Corpe et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells

(2010) Tung-Liang Chung et al.   STEM CELLS

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

(2009) Jens Lykkesfeldt et al.   BRITISH JOURNAL OF NUTRITION

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

(2009) Julien Verrax et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sailors' scurvy before and after James Lind - a reassessment

(2009) Jeremy Hugh Baron   NUTRITION REVIEWS

Hepatic Lipid Peroxidation and Antioxidant Micronutrients in Hepatitis Virus C Liver Recipients With and Without Disease Recurrence

(2009) J. Madill et al.   TRANSPLANTATION PROCEEDINGS

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

(2008) L. J. Hoffer et al.   ANNALS OF ONCOLOGY

The controversial place of vitamin C in cancer treatment

(2008) J. Verrax et al.   BIOCHEMICAL PHARMACOLOGY

Vitamins B depletion, lower iron status and decreased antioxidative defense in patients with chronic hepatitis C treated by pegylated interferon alfa and ribavirin

(2008) Chun-che Lin et al.   CLINICAL NUTRITION

Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences

(2008) María Luisa Rivas et al.   EMBO REPORTS

Genetic Variation in Sodium-Dependent Vitamin C TransportersSLC23A1andSLC23A2and Risk of Advanced Colorectal Adenoma

(2008) Hans Christian Erichsen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of vitamin C on bisphenol A, nonylphenol and octylphenol induced brain damages of male rats

(2008) Müfide Aydoğan et al.   TOXICOLOGY