The Pharmacokinetics of Vitamin C

Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis

(2019) Aileen Hill et al.   Nutrients

Ascorbic acid metabolism and functions: A comparison of plants and mammals

(2018) Nicholas Smirnoff   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin C for the treatment of sepsis: The scientific rationale

(2018) Paul E. Marik   PHARMACOLOGY & THERAPEUTICS

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence

(2018) Margreet C. M. Vissers et al.   Frontiers in Physiology

Dual-targeting for brain-specific liposomes drug delivery system: Synthesis and preliminary evaluation

(2018) Yao Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial

(2018) Shaun A. Mason et al.   DIABETES OBESITY & METABOLISM

Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue

(2018) Joshua D. Schoenfeld et al.   SEMINARS IN RADIATION ONCOLOGY

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome

(2018) Maret G. Traber et al.   Redox Biology

The safety and pharmacokinetics of high dose intravenous ascorbic acid synergy with modulated electrohyperthermia in Chinese patients with stage III-IV non-small cell lung cancer

(2017) Junwen Ou et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of the targeted delivery of 5-fluorouracil and ascorbic acid into the brain with ultrasound-responsive nanobubbles

(2017) Yusuke Miura et al.   JOURNAL OF DRUG TARGETING

Poor Vitamin C Status Late in Pregnancy Is Associated with Increased Risk of Complications in Type 1 Diabetic Women: A Cross-Sectional Study

(2017) Bente Juhl et al.   Nutrients

Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo

(2017) Hongbin Tu et al.   EBioMedicine

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

(2016) Elizabeth J. Campbell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Is Diabetes Associated with Lower Vitamin C Status in Pregnant Women? A Prospective Study

(2016) Bente Juhl et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

l -dehydroascorbic acid can substitute l -ascorbic acid as dietary vitamin C source in guinea pigs

(2016) Henriette Frikke-Schmidt et al.   Redox Biology

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy

(2016) Claire M. Doskey et al.   Redox Biology

Genetically high plasma vitamin C, intake of fruit and vegetables, and risk of ischemic heart disease and all-cause mortality: a Mendelian randomization study

(2015) Camilla J Kobylecki et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Ascorbic acid efflux from human brain microvascular pericytes: Role of re-uptake

(2015) James M. May et al.   BIOFACTORS

Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs

(2015) Stine Hasselholt et al.   BRITISH JOURNAL OF NUTRITION

Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

(2015) Hongbin Tu et al.   EBioMedicine

Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation

(2014) Torben K. Nielsen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs

(2014) Janne Gram Schjoldager et al.   EUROPEAN JOURNAL OF NUTRITION

High-dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males

(2014) Shaun A. Mason et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue

(2014) Caroline Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

(2014) Alpha A Fowler et al.   Journal of Translational Medicine

In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain

(2014) Ditte Søgaard et al.   NUTRITION RESEARCH

Does Vitamin C Deficiency Affect Cognitive Development and Function?

(2014) Stine Hansen et al.   Nutrients

Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains

(2014) Maya D. Paidi et al.   Redox Biology

Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin C Transport and Antioxidant Enzyme Function

(2013) Alexander J. Michels et al.   Annual Review of Nutrition

Does Vitamin C Deficiency Increase Lifestyle-Associated Vascular Disease Progression? Evidence Based on Experimental and Clinical Studies

(2013) Pernille Tveden-Nyborg et al.   ANTIOXIDANTS & REDOX SIGNALING

Conserved or Lost: Molecular Evolution of the Key Gene GULO in Vertebrate Vitamin C Biosynthesis

(2013) Hongwen Yang   BIOCHEMICAL GENETICS

Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs

(2013) Janne G. Schjoldager et al.   BRITISH JOURNAL OF NUTRITION

Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer

(2013) Christopher M. Stephenson et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Intestinal Dehydroascorbic Acid (DHA) Transport Mediated by the Facilitative Sugar Transporters, GLUT2 and GLUT8

(2013) Christopher P. Corpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

(2013) Anitra Carr et al.   Nutrients

Regulation of Vitamin C Homeostasis during Deficiency

(2013) Maiken Lindblad et al.   Nutrients

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?

(2012) Balz Frei et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs

(2012) Pernille Tveden-Nyborg et al.   PLoS One

Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy

(2011) Ping Chen et al.   ANTI-CANCER DRUGS

Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs

(2011) Pernille Tveden-Nyborg et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter

(2011) Lorena Mardones et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion

(2011) M. Elizabeth Meredith et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low ascorbic acid and increased oxidative stress in gulo(−/−) mice during development

(2010) Fiona E. Harrison et al.   BRAIN RESEARCH

High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs

(2010) Henriette Frikke-Schmidt et al.   BRITISH JOURNAL OF NUTRITION

Multivitamins, Individual Vitamin and Mineral Supplements, and Risk of Diabetes Among Older U.S. Adults

(2010) Y. Song et al.   DIABETES CARE

Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice

(2010) Christopher P. Corpe et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs

(2009) Pernille Tveden-Nyborg et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabetes

(2009) Michal Odermarsky et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of Marginal Vitamin C Deficiency in Atherogenesis:In VivoModels and Clinical Studies

(2009) Henriette Frikke-Schmidt et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries

(2009) J Villar et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

(2009) Jens Lykkesfeldt et al.   BRITISH JOURNAL OF NUTRITION

Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2

(2009) Fiona E. Harrison et al.   FREE RADICAL BIOLOGY AND MEDICINE

Does vitamin C deficiency result in impaired brain development in infants?

(2009) Pernille Tveden-Nyborg et al.   REDOX REPORT

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA