Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis

The Osteocyte: New Insights

(2020) Alexander G. Robling et al.   Annual Review of Physiology

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

(2020) Lijun Wang et al.   Nature Communications

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

(2020) Sharon L. Kolasinski et al.   Arthritis & Rheumatology

Co–culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches

(2020) Giorgia Borciani et al.   Acta Biomaterialia

Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis

(2020) Lianzhi Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow-up

(2020) Philippe Hernigou et al.   INTERNATIONAL ORTHOPAEDICS

Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions

(2020) Guoqi Cai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Specific inhibition of FAK signaling attenuates subchondral bone deterioration and articular cartilage degeneration during osteoarthritis pathogenesis

(2020) Hangtian Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

(2020) Jianxi Zhu et al.   eLife

Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study

(2020) Philippe Hernigou et al.   INTERNATIONAL ORTHOPAEDICS

Bisphosphonate use is protective of radiographic knee osteoarthritis progression among those with low disease severity and being non‐overweight: data from the Osteoarthritis Initiative

(2020) Kaleen N. Hayes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of body weight‐supported treadmill training on cartilage‐subchondral bone unit in the rat model of posttraumatic osteoarthritis

(2020) Xiaoxia Hao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development

(2020) Weiping Su et al.   JCI Insight

Defactinib attenuates osteoarthritis by inhibiting positive feedback loop between H-type vessels and MSCs in subchondral bone

(2020) Yanjun Hu et al.   Journal of Orthopaedic Translation

Growth factor signalling in osteoarthritis

(2019) Jian Huang et al.   GROWTH FACTORS

Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial

(2019) Woo-Suk Lee et al.   Stem Cells Translational Medicine

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial

(2019) Julien Freitag et al.   Regenerative Medicine

Intra-articular injection of mesenchymal stem cells for clinical outcomes and cartilage repair in osteoarthritis of the knee: a meta-analysis of randomized controlled trials

(2019) Seong Hwan Kim et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

International Expert Consensus on a Cell Therapy Communication Tool

(2019) Iain R. Murray et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Treatment of knee osteoarthritis with intra-articular injection of autologous adipose-derived mesenchymal progenitor cells: a prospective, randomized, double-blind, active-controlled, phase IIb clinical trial

(2019) Liangjing Lu et al.   Stem Cell Research & Therapy

Role of NGF-TrkA signaling in calcification of articular chondrocytes

(2019) Yangzi Jiang et al.   FASEB JOURNAL

Raloxifene retards cartilage degradation and improves subchondral bone micro-architecture in ovariectomized rats with patella baja-induced - patellofemoral joint osteoarthritis

(2019) M.-J. Bei et al.   OSTEOARTHRITIS AND CARTILAGE

Artesunate, an Anti-Malaria Agent, Attenuates Experimental Osteoarthritis by Inhibiting Bone Resorption and CD31hiEmcnhi Vessel Formation in Subchondral Bone

(2019) Yicheng Li et al.   Frontiers in Pharmacology

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

(2019) Natalie A. Sims et al.   Annual Review of Physiology

YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling

(2019) Christopher D Kegelman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis

(2019) Philip G. Conaghan et al.   ANNALS OF INTERNAL MEDICINE

Targeting downstream subcellular YAP activity as a function of matrix stiffness with Verteporfin-encapsulated chitosan microsphere attenuates osteoarthritis

(2019) Xianzhu Zhang et al.   BIOMATERIALS

Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

(2019) Michael R McClung et al.   Lancet Diabetes & Endocrinology

First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions

(2018) Kazunori Shimomura et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Alterations of Subchondral Bone Progenitor Cells in Human Knee and Hip Osteoarthritis Lead to a Bone Sclerosis Phenotype

(2018) Daniel Bianco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Subchondral stem cell therapy versus contralateral total knee arthroplasty for osteoarthritis following secondary osteonecrosis of the knee

(2018) Philippe Hernigou et al.   INTERNATIONAL ORTHOPAEDICS

Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice

(2018) Jiansen Lu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Articular cartilage protection in Ctsk-/- mice is associated with cellular and molecular changes in subchondral bone and cartilage matrix

(2018) Fabiana N. Soki et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

(2018) Erik Lindström et al.   Journal of Translational Medicine

Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials

(2018) E.E. Vaysbrot et al.   OSTEOARTHRITIS AND CARTILAGE

Comparison of secretome from osteoblasts derived from sclerotic versus non-sclerotic subchondral bone in OA: A pilot study

(2018) Christelle Sanchez et al.   PLoS One

Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

(2018) Yang Song et al.   Regenerative Medicine

Gefitinib for Epidermal Growth Factor Receptor Activated Osteoarthritis Subpopulation Treatment

(2018) Heng Sun et al.   EBioMedicine

Magnoflorine with hyaluronic acid gel promotes subchondral bone regeneration and attenuates cartilage degeneration in early osteoarthritis

(2018) Zhe Cai et al.   BONE

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

(2018) Jose Matas et al.   Stem Cells Translational Medicine

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

(2018) Shouan Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

The biology of normal bone remodelling

(2017) P. Katsimbri   EUROPEAN JOURNAL OF CANCER CARE

Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis

(2017) Yan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of an over-ground exoskeleton on external knee moments during stance phase of gait in healthy adults

(2017) Chris A. McGibbon et al.   KNEE

Clinical settings in knee osteoarthritis: Pathophysiology guides treatment

(2017) Gabriel Herrero-Beaumont et al.   MATURITAS

Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model

(2017) Christian G. Pfeifer et al.   TISSUE ENGINEERING PART C-METHODS

Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling

(2017) Neha S. Dole et al.   Cell Reports

A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis

(2016) Shane A. Shapiro et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Morphological characteristics of cartilage-bone transitional structures in the human knee joint and CAD design of an osteochondral scaffold

(2016) Weiguo Bian et al.   Biomedical Engineering Online

Merck & Co. drops osteoporosis drug odanacatib

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

(2016) Zhi-Hong Wen et al.   Scientific Reports

Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration

(2016) Yangzi Jiang et al.   Stem Cells Translational Medicine

Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up

(2016) Yong-Beom Park et al.   Stem Cells Translational Medicine

Small-Diameter Awls Improve Articular Cartilage Repair After Microfracture Treatment in a Translational Animal Model

(2015) Patrick Orth et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

(2015) Zhuang Cui et al.   ANNALS OF THE RHEUMATIC DISEASES

Arthroscopic Transplantation of Synovial Stem Cells Improves Clinical Outcomes in Knees With Cartilage Defects

(2015) Ichiro Sekiya et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Assessment of the injection behavior of commercially available bone BSMs for Subchondroplasty® procedures

(2015) Dinely A. Colon et al.   KNEE

Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis

(2015) Y. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials

(2015) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage Repair and Subchondral Bone Remodeling in Response to Focal Lesions in a Mini-Pig Model: Implications for Tissue Engineering

(2015) Matthew B. Fisher et al.   TISSUE ENGINEERING PART A

Wolff’s law in action: a mechanism for early knee osteoarthritis

(2015) Andrew J. Teichtahl et al.   ARTHRITIS RESEARCH & THERAPY

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

(2014) Janet L. Crane et al.   JOURNAL OF CLINICAL INVESTIGATION

Chondroprotective effect of high-dose zoledronic acid: An experimental study in a rabbit model of osteoarthritis

(2014) Kalliopi Lampropoulou-Adamidou et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Identical subchondral bone microarchitecture pattern with increased bone resorption in rheumatoid arthritis as compared to osteoarthritis

(2014) G. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway

(2014) R.G. Rosa et al.   OSTEOARTHRITIS AND CARTILAGE

Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis

(2014) O. Bruyere et al.   RHEUMATOLOGY

Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis

(2014) Toshihiro Nagai et al.   ARTHRITIS RESEARCH & THERAPY

Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice

(2014) Thomas Funck-Brentano et al.   Arthritis & Rheumatology

Incorporation of bioactive polyvinylpyrrolidone–iodine within bilayered collagen scaffolds enhances the differentiation and subchondral osteogenesis of mesenchymal stem cells

(2013) Yangzi Jiang et al.   Acta Biomaterialia

Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats

(2013) Songsong Zhu et al.   BONE

The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits

(2013) Pia Rosgaard Jensen et al.   CALCIFIED TISSUE INTERNATIONAL

Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

(2013) P-Y. Yang et al.   EUROPEAN JOURNAL OF PAIN

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Expanding Applications of the Subchondroplasty Procedure for the Treatment of Bone Marrow Lesions Observed on Magnetic Resonance Imaging

(2013) Jack Farr et al.   OPERATIVE TECHNIQUES IN SPORTS MEDICINE

Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

(2013) T. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis – a case for personalized health care?

(2013) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

(2013) Guangyi Li et al.   ARTHRITIS RESEARCH & THERAPY

Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial

(2012) Laura Louise Laslett et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

(2012) Jean-Yves Reginster et al.   ANNALS OF THE RHEUMATIC DISEASES

Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: The In Vitro Osteoclast Differentiation in Arthritis study

(2012) Marianne Durand et al.   ARTHRITIS AND RHEUMATISM

Phenotypic Characterization of Osteoarthritic Osteocytes from the Sclerotic Zones: A Possible Pathological Role in Subchondral Bone Sclerosis

(2012) Anjali Jaiprakash et al.   International Journal of Biological Sciences

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Bone remodelling in osteoarthritis

(2012) David B. Burr et al.   Nature Reviews Rheumatology

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis

(2012) David D McErlain et al.   ARTHRITIS RESEARCH & THERAPY

Characterization of Subchondral Bone Repair for Marrow-Stimulated Chondral Defects and Its Relationship to Articular Cartilage Resurfacing

(2011) Hongmei Chen et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study

(2011) F. Intema et al.   ANNALS OF THE RHEUMATIC DISEASES

Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts

(2011) Steeve Kwan Tat et al.   BONE

Expression of vascular endothelial growth factor in normal, osteoarthritic and osteoporotic osteoblasts

(2011) Addolorata Corrado et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

(2011) Thomas F. Chan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

(2011) E. R. Sampson et al.   Science Translational Medicine

Autologous Chondrocyte Implantation

(2010) Lars Peterson et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Biochemical and molecular mechanisms of action of bisphosphonates

(2010) Michael J. Rogers et al.   BONE

Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

(2010) Femke Intema et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Advanced hip osteoarthritis: magnetic resonance imaging aspects and histopathology correlations

(2010) H. Leydet-Quilici et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study

(2010) S. K. Tanamas et al.   RHEUMATOLOGY

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

(2010) Miriam Bellido et al.   ARTHRITIS RESEARCH & THERAPY

Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats

(2009) Je-Ken Chang et al.   ARTHRITIS AND RHEUMATISM

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

(2009) Denis Couchourel et al.   ARTHRITIS AND RHEUMATISM

In situ measurement of transport between subchondral bone and articular cartilage

(2009) Jun Pan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

(2009) J.R. Connor et al.   OSTEOARTHRITIS AND CARTILAGE

Association of bone scintigraphic abnormalities with knee malalignment and pain

(2008) V B Kraus et al.   ANNALS OF THE RHEUMATIC DISEASES

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone

(2008) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells

(2008) Fraser P. Coxon et al.   BONE

Role of Bone in Osteoarthritis Pathogenesis

(2008) Steven R. Goldring   MEDICAL CLINICS OF NORTH AMERICA

Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3T

(2008) R.I. Bolbos et al.   OSTEOARTHRITIS AND CARTILAGE

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response

(2008) G. J. Atkins et al.   OSTEOPOROSIS INTERNATIONAL

Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology

(2008) Mihra S. Taljanovic et al.   SKELETAL RADIOLOGY