Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure

Low fibre intake is associated with gut microbiota alterations in chronic heart failure

(2020) Cristiane C.K. Mayerhofer et al.   ESC Heart Failure

Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes

(2020) Bu Jin et al.   International Heart Journal

3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice

(2020) Guangji Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

(2020) Chelsea L. Organ et al.   Journal of the American Heart Association

The potential role of the gut microbiota in shaping host energetics and metabolic rate

(2020) Elle C. Lindsay et al.   JOURNAL OF ANIMAL ECOLOGY

Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia

(2020) Marina Makrecka‐Kuka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Trimethylamine N-Oxide Does Not Impact Viability, ROS Production, and Mitochondrial Membrane Potential of Adult Rat Cardiomyocytes

(2019) Querio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts

(2018) Martin Kummen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut

(2018) Eleanor Jameson et al.   METHODS

Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide

(2018) Monia Savi et al.   MOLECULES

Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response

(2018) Jia-mei Yang et al.   MOLECULES

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts

(2018) Ramón Estruch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trimethylamine N -oxide: A harmful, protective or diagnostic marker in lifestyle diseases?

(2018) Artur Nowiński et al.   NUTRITION

CHRONIC, LOW-DOSE TMAO TREATMENT REDUCES DIASTOLIC DYSFUNCTION AND HEART FIBROSIS IN HYPERTENSIVE RATS.

(2018) Tomasz Huc et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism

(2018) Lin Ding et al.   Lipids in Health and Disease

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

(2018) Manuel Janeiro et al.   Nutrients

Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome

(2018) Luigi Barrea et al.   Nutrients

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

(2017) Marina Makrecka-Kuka et al.   TOXICOLOGY LETTERS

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

(2017) Tiejun Li et al.   Frontiers in Physiology

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression

(2016) Nikole J. Byrne et al.   CARDIOVASCULAR RESEARCH

Doxorubicin toxicity changes myocardial energy metabolism in rats

(2016) Rong Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

TrimethylamineN-oxide and prognosis in acute heart failure

(2016) Toru Suzuki et al.   HEART

Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial

(2016) Clara E. Cho et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

(2016) Małgorzata Nita et al.   Oxidative Medicine and Cellular Longevity

The Mediterranean Diet, its Components, and Cardiovascular Disease

(2015) R. Jay Widmer et al.   AMERICAN JOURNAL OF MEDICINE

Determination of trimethylamine-N-oxide in combination withl-carnitine andγ-butyrobetaine in human plasma by UPLC/MS/MS

(2015) Solveiga Grinberga et al.   BIOMEDICAL CHROMATOGRAPHY

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

(2015) W.H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats

(2014) Marcin Ufnal et al.   CANADIAN JOURNAL OF CARDIOLOGY

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria

(2014) Marina Makrecka et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study

(2014) Michael Lever et al.   PLoS One

Fish consumption and its possible preventive role on the development and prevalence of metabolic syndrome - a systematic review

(2014) Christine Tørris et al.   Diabetology & Metabolic Syndrome

Chemical Chaperones Mitigate Experimental Asthma by Attenuating Endoplasmic Reticulum Stress

(2013) Lokesh Makhija et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endoplasmic Reticulum Stress Plays a Key Role in the Pathogenesis of Diabetic Peripheral Neuropathy

(2013) S. Lupachyk et al.   DIABETES

Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis

(2013) Maija Dambrova et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Heart energy metabolism impairment in Western-diet induced obese mice

(2013) Fabiana A. Neves et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The heart is better protected against myocardial infarction in the fed state compared to the fasted state

(2013) Edgars Liepinsh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Mitochondrial dysfunction in heart failure

(2012) Mariana G. Rosca et al.   HEART FAILURE REVIEWS

The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine

(2011) Janis Kuka et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Bioenergetics of the failing heart

(2010) Renée Ventura-Clapier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress

(2009) Eric R. Griffiths et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Characterization of l-aminocarnitine, an inhibitor of fatty acid oxidation

(2008) Malika Chegary et al.   MOLECULAR GENETICS AND METABOLISM