Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

(2017) Xinmin S. Li et al.   EUROPEAN HEART JOURNAL

Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans

(2017) Matthew Kennedy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

(2017) Marina Makrecka-Kuka et al.   TOXICOLOGY LETTERS

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

(2017) W.H. Wilson Tang et al.   Translational Research

Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice

(2017) Kui Chen et al.   Frontiers in Physiology

Antiatherogenic effects of ellagic acid and urolithins in vitro

(2016) Laura Mele et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

(2016) Valentina Spigoni et al.   MOLECULES

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

(2016) Ming-liang Chen et al.   mBio

Parenchymal and Stromal Cells Contribute to Pro-Inflammatory Myocardial Environment at Early Stages of Diabetes: Protective Role of Resveratrol

(2016) Monia Savi et al.   Nutrients

Trimethylamine N-Oxide: The Good, the Bad and the Unknown

(2016) Manuel Velasquez et al.   Toxins

Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)

(2016) Katie A. Meyer et al.   Journal of the American Heart Association

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance

(2015) Thomas K. Sin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

(2015) W.H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

TMAO: A small molecule of great expectations

(2015) Marcin Ufnal et al.   NUTRITION

Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions

(2015) Roberto Sala et al.   Journal of Functional Foods

Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota

(2015) Wei-Kai Wu et al.   Journal of Functional Foods

Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolism

(2015) Ilaria Zanotti et al.   Food & Function

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Phenolic Compounds

(2015) Oscar Rangel-Huerta et al.   Nutrients

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

(2014) Ana Rodriguez-Mateos et al.   ARCHIVES OF TOXICOLOGY

Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats

(2014) Marcin Ufnal et al.   CANADIAN JOURNAL OF CARDIOLOGY

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

(2014) Francisco A. Tomás-Barberán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

(2014) Diana M. Shih et al.   JOURNAL OF LIPID RESEARCH

Gut microbiota: An environmental risk factor for cardiovascular disease

(2013) Jane Stock   ATHEROSCLEROSIS

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

(2013) Juan Carlos Espín et al.   Evidence-based Complementary and Alternative Medicine

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correction: Fractalkine Depresses Cardiomyocyte Contractility

(2013) David Taube et al.   PLoS One

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Perturbation of the EphA2–EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites

(2012) Massimiliano Tognolini et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

(2009) M. Sulaiman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure

(2008) Cathrine Husberg et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

(2008) Francois-Pierre J Martin et al.   Molecular Systems Biology