Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC

(2020) Caroline Volz et al.   Cell Reports

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

(2020) Ross O Smith et al.   eLife

A meta‐analysis of the relationship between VEGFR2 polymorphisms and atherosclerotic cardiovascular diseases

(2019) Li Wang et al.   CLINICAL CARDIOLOGY

SALM4 regulates angiogenic functions in endothelial cells through VEGFR2 phosphorylation at Tyr1175

(2019) Dong Young Kim et al.   FASEB JOURNAL

N-glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2)

(2019) Kevin Brown Chandler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain 7

(2019) Rossella Di Stasi et al.   MOLECULAR BIOTECHNOLOGY

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

6′-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis

(2019) Tae-Wook Chung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

VEGF/VEGFR2 signaling regulates hippocampal axon branching during development

(2019) Robert Luck et al.   eLife

Vascular endothelial growth factor signaling in development and disease

(2018) Sinem Karaman et al.   DEVELOPMENT

EphrinB2/EphB4 signaling regulates non‐sprouting angiogenesis by VEGF

(2018) Elena Groppa et al.   EMBO REPORTS

Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications

(2018) Songyan Han et al.   Stem Cell Research

Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway

(2018) Lijun Ji et al.   MOLECULES

Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases

(2018) Asghar Fallah et al.   BIOMEDICINE & PHARMACOTHERAPY

The Role of PDGFs and PDGFRs in Colorectal Cancer

(2017) Roberta M. Manzat Saplacan et al.   MEDIATORS OF INFLAMMATION

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Site-Specific N-Glycosylation of Endothelial Cell Receptor Tyrosine Kinase VEGFR-2

(2016) Kevin Brown Chandler et al.   JOURNAL OF PROTEOME RESEARCH

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

VEGFR-2 conformational switch in response to ligand binding

(2016) Sarvenaz Sarabipour et al.   eLife

Interleukin-6 Stimulates Defective Angiogenesis

(2015) G. Gopinathan et al.   CANCER RESEARCH

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Angiogenesis in diabetes and obesity

(2015) Rui Cheng et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Developmental and pathological angiogenesis in the central nervous system

(2014) Mario Vallon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation

(2014) Sandro Manni et al.   FASEB JOURNAL

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation

(2014) Sandro Manni et al.   STRUCTURE

Probiotic Yeast Inhibits VEGFR Signaling and Angiogenesis in Intestinal Inflammation

(2013) Xinhua Chen et al.   PLoS One

VEGFR and Type-V RTK Activation and Signaling

(2013) M. Shibuya   Cold Spring Harbor Perspectives in Biology

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

(2012) Rui Benedito et al.   NATURE

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte growth factor stimulated angiogenesis without inflammation: Differential actions between hepatocyte growth factor, vascular endothelial growth factor and basic fibroblast growth factor

(2012) Toshihiro Kaga et al.   VASCULAR PHARMACOLOGY

Angiogenesis in rheumatoid arthritis: A disease specific process or a common response to chronic inflammation?

(2011) Alessandra Marrelli et al.   AUTOIMMUNITY REVIEWS

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

(2011) M. S. Brozzo et al.   BLOOD

Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer

(2011) Samar Masoumi Moghaddam et al.   CANCER AND METASTASIS REVIEWS

Structural bases of physiological functions and roles of the vacuolar H+-ATPase

(2011) Binyun Ma et al.   CELLULAR SIGNALLING

Focal adhesion kinase and tumour angiogenesis

(2011) Tanguy Lechertier et al.   JOURNAL OF PATHOLOGY

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

VEGFR2 (KDR/Flk1) Signaling Mediates Axon Growth in Response to Semaphorin 3E in the Developing Brain

(2010) Anaïs Bellon et al.   NEURON

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

(2010) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing the Effects of the Juxtamembrane Domain on Vascular Endothelial Growth Factor Receptor-2 Enzymatic Activity, Autophosphorylation, and Inhibition by Axitinib

(2009) James Solowiej et al.   BIOCHEMISTRY

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

VEGFR2-PLC 1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells

(2009) H. Sase et al.   JOURNAL OF CELL SCIENCE

Transforming growth factor-beta 1 (TGF-β1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis

(2009) Giovanni Ferrari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential Regulation of VEGF Signaling by PKC-α and PKC-ε in Endothelial Cells

(2008) Christian Rask-Madsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential roles of PDGFR-α and PDGFR-β in angiogenesis and vessel stability

(2008) Junhang Zhang et al.   FASEB JOURNAL

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE