Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cell Biology
Huang-Ming Chang, Kang-Yung Peng, Chieh-Kai Chan, Chiao-Yin Sun, Ying-Ying Chen, Han-Mei Chang, Chun-Lin Huang, Pei-Chun Liu, Peng-Ying Chen, Kuo-Chuan Wang, Wei-Jie Wang, Chen-Chi Wu, Yu-Feng Lin, Tai-Shuan Lai, Tao-Min Huang, Guang-Huar Young, Shuei-Liong Lin, Marlies Ostermann, Tzong-Shinn Chu, Jeff S. Chueh, Vin-Cent Wu
Summary: This study reveals the protective role of FGF23 in AKI, promoting renal regeneration, vascular repair, and attenuating damage. FGF23 interacts with the SDF-1/CXCR4 signaling, inhibiting EPC senescence and migration, while not affecting angiogenesis.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Minyoung Noh, Haiying Zhang, Hyejeong Kim, Songyi Park, Young-Myeong Kim, Young-Guen Kwon
Summary: Endothelial barrier integrity is crucial for vascular homeostasis, while hyperpermeability is involved in the progression of various pathological conditions. Primaquine diphosphate (PD), originally an antimalarial drug, shows potential as a blocker of vascular leakage by maintaining endothelial integrity. This effect is achieved by inhibiting VEGF-induced disruption and stabilizing cortactin actin rings through the mechanism of ubiquitin specific protease 1 (USP1) inhibition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Sevil Korkmaz-Icoz, Marcel Schwar, Sivakkanan Loganathan, Kristin Wachter, Adrian- Iustin Georgevici, Patricia Kraft, Tobias Mayer, Andreas Simm, Matthias Karck, Gabor Szabo
Summary: The study found that bread crust extract can protect vascular grafts from ischemia/reperfusion injury and improve their function. This may be achieved through regulating multiple gene expressions and reducing oxidative stress responses.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Behavioral Sciences
Wenyu Zhang, Lin Han, Yan Wen, Lixian Su, Yibing Li, Xudong Luo
Summary: This study found that electroacupuncture (EA) can promote angiogenesis and provide brain protection through the activation of the VEGF/Notch signaling pathway after ischemic stroke.
BRAIN AND BEHAVIOR
(2023)
Article
Cell & Tissue Engineering
Sevil Korkmaz-Icoez, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamas Radovits, Alex Ali Sayour, Mihaly Ruppert, Gabor Veres, Matthias Karck, Gabor Szabo
Summary: The study demonstrates that the use of CM from bone marrow MSCs can protect vascular grafts in BD rats, alleviating endothelial dysfunction caused by IR injury and reducing levels of inflammation and apoptosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sevil Korkmaz-Icoez, Cenk Kocer, Alex A. Sayour, Patricia Kraft, Mona Benker, Sophia Abulizi, Adrian-Iustin Georgevici, Paige Brlecic, Tamas Radovits, Sivakkanan Loganathan, Matthias Karck, Gabor Szabo
Summary: This study showed that adding the SGLT-2 inhibitor canagliflozin to saline can protect vascular grafts from ischemia/reperfusion injury, and significantly improve endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Sevil Korkmaz-Icoez, Belinda Ballikaya, Jasmin Soethoff, Patricia Kraft, Alex Ali Sayour, Tamas Radovits, Sivakkanan Loganathan, Matthias Karck, Gabor Szabo, Gabor Veres
Summary: DuraGraft(R) has been shown to improve vascular function of arterial grafts subjected to IRI, protecting endothelial function and enhancing vascular contractile ability.
Article
Pharmacology & Pharmacy
Yingying Liu, Wenjie Li, Xinyi Ma, Jibing He, Yi Lin, Dingsheng Lin
Summary: This study examined the effect of rivastigmine on flap survival in rats and found that it can increase angiogenesis, improve flap survival, reduce inflammation, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Keisuke Shirakura, Yoshiaki Okada
Summary: Robo4, specifically expressed in vascular endothelial cells, plays a crucial role in preventing vascular leakage and promoting angiogenesis. Research has shown that Robo4 modulates endothelial barrier function through distinct mechanisms and is involved in vascular endothelial growth factor and inflammation-mediated signaling pathways.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Cell Biology
Kenichiro Suno, Yasushige Shingu, Satoru Wakasa
Summary: This study evaluated the effects of trehalose preconditioning on cardiac and coronary endothelial function after ischemia-reperfusion injury. It was found that trehalose preconditioning improved heart function, reduced edema, oxidative stress, and apoptosis, and increased eNOS dimerization ratio, indicating its protective effects on cardiac and coronary endothelial function. These effects were mediated through the eNOS signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Miaomiao Tian, Kan Chen, Jianhua Huang, Dongqing Chu, Jialin Li, Keqiang Huang, Chunyu Ma
Summary: Asiatic acid (AA) has demonstrated inhibitory effects on angiogenesis in breast cancer models both in vitro and in vivo, potentially through downregulating the VEGF/VEGFR2 signal axis to inhibit cancer growth and metastasis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Luyan Yao, Funan He, Quanyi Zhao, Dandan Li, Shufang Fu, Mingzhi Zhang, Xingzhong Zhang, Bingying Zhou, Li Wang
Summary: Imaging mass cytometry was used to characterize the spatial distribution and dynamics of cell phenotypes and communities in the mouse left ventricle following myocardial infarction. H3K9me3 in endothelial cells was identified as a potential therapeutic target for alleviating pathological remodeling of the heart after ischemia-reperfusion injury.
CIRCULATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wenjun Li, Yuriko Terada, Yulia Y. Tyurina, Vladimir A. Tyurin, Amit Bery, Jason M. Gauthier, Ryuji Higashikubo, Alice Y. Tong, Dequan Zhou, Felix Nunez-Santana, Emilia Lecuona, Adil Hassan, Kohei Hashimoto, Davide Scozzi, Varun Puri, Ruben G. Nava, Alexander S. Krupnick, Kory J. Lavine, Andrew E. Gelman, Mark J. Miller, Valerian E. Kagan, Ankit Bharat, Daniel Kreisel
Summary: Ischemia reperfusion injury is a common pathological condition triggered by the release of endogenous ligands. In this study, the researchers discovered that necroptosis, a nonapoptotic form of cell death, triggers the recruitment of neutrophils in injured lungs. Initially, neutrophils traffic predominantly to subpleural vessels, guided by chemoattractants produced by nonclassical monocytes. The disruption of pulmonary capillaries by neutrophils leads to vascular leakage and impaired graft function. The study also found that TLR4 signaling and NADPH oxidase 4 expression mediate the arrest of neutrophils, preventing their extravasation. The formation of neutrophil extracellular traps in injured lungs can be disrupted with DNase to prevent vascular leakage and improve graft dysfunction. These findings could have important implications for the development of therapeutics to protect lungs from ischemia reperfusion injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Shu Yan, Ji Hu, Jia Li, Pengchao Wang, Yilong Wang, Zhaohui Wang
Summary: PRMT4 is upregulated in ischemic muscles and promotes angiogenesis. It regulates VEGF expression by interacting with YB1. Knockdown of YB1 attenuates PRMT4-mediated angiogenic effects in vitro.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Hyejeong Kim, Yeongrim Ko, Hyojin Park, Haiying Zhang, Yoonjeong Jeong, Yeomyeong Kim, Minyoung Noh, Songyi Park, Young-Myeong Kim, Young-Guen Kwon
EXPERIMENTAL AND MOLECULAR MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Ye-Seul Kim, Haiying Zhang, Sunghye Lee, Songyi Park, Minyoung Noh, Young-Myeong Kim, Young-Guen Kwon
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Immunology
Songyi Park, Ji Hoon Oh, Dong Jin Park, Haiying Zhang, Minyoung Noh, Yeomyung Kim, Ye-Seul Kim, Hyejeong Kim, Young-Myeong Kim, Sang-Jun Ha, Young-Guen Kwon
Summary: Stabilizing tumor blood vessels and modifying the tumor microenvironment with the endothelial dysfunctional blocker CU06-1004 can synergize with anti-PD-1 immunotherapy, leading to decreased tumor growth, increased T-cell infiltration and activity, reduced hypoxia, and vessel density. These effects are significantly associated with enhanced expression of IFN gamma and PD-L1 in tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Minyoung Noh, Haiying Zhang, Hyejeong Kim, Songyi Park, Young-Myeong Kim, Young-Guen Kwon
Summary: Endothelial barrier integrity is crucial for vascular homeostasis, while hyperpermeability is involved in the progression of various pathological conditions. Primaquine diphosphate (PD), originally an antimalarial drug, shows potential as a blocker of vascular leakage by maintaining endothelial integrity. This effect is achieved by inhibiting VEGF-induced disruption and stabilizing cortactin actin rings through the mechanism of ubiquitin specific protease 1 (USP1) inhibition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haiying Zhang, Hyeok Kim, Bong Woo Park, Minyoung Noh, Yeomyeong Kim, Jeongeun Park, Jae-Hyun Park, Jin-Ju Kim, Woo-Sup Sim, Kiwon Ban, Hun-Jun Park, Young-Guen Kwon
Summary: The drug CU06-1004 has shown potential in improving cardiac function by inhibiting CMEC hyperpermeability and reducing inflammation and infiltration in infarcted hearts. It enhances vascular integrity, reduces tissue damage, and provides a promising therapeutic option for preventing lethal myocardial I/R injury.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Ik Soo Lee, Chan-Sik Kim, Junghyun Kim, Kyuhyung Jo, Soo Wang Hyun, Haiying Zhang, MinYoung Noh, Young-Guen Kwon, MyungHwa Kim, Jin Sook Kim
Summary: The combined extract of Moutan radicis cortex and Cinnamomi ramulus showed inhibitory effect against laser-induced pathological CNV by reducing lesion areas and fluorescein leakage. The extract and its constituents also decreased cell migration, tube formation, and hyper permeability while inhibiting phosphorylation of FAK and p38 MAPK, suggesting potential therapeutic strategies for wet AMD patients.
Article
Pharmacology & Pharmacy
Minyoung Noh, Yeomyeong Kim, Haiying Zhang, Hyejeong Kim, Cho-Rong Bae, Sunghye Lee, Young-Guen Kwon
Summary: Retinal vascular diseases are a major cause of blindness worldwide, with common mechanisms including VEGF signaling, hypoxia, and inflammation. Current treatments improve outcomes but have limitations and side effects. A new therapeutic approach, such as oral administration of CU06-1004, could potentially address the underlying cause and provide better treatment for retinal vascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Allergy
Sunghye Lee, Yeomyeong Kim, Ye-Seul Kim, Haiying Zhang, Minyoung Noh, Young-Guen Kwon
Summary: In this study, CU06-1004 was found to alleviate vascular hyperpermeability caused by BK by protecting endothelial barrier function. The results suggest that CU06-1004 could serve as a potential prophylactic/therapeutic approach for HAE.