Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Yuxian Wu, Jinghai Gao, Xiaojun Liu
Summary: The study showed that upregulation of ANGPTL4 in ovarian cancer cells led to increased tumor angiogenesis, growth, and metastasis inhibition. Inactivation of VEGFR2 Y949 phosphorylation eliminated the tumor-suppressive effects of ANGPTL4 inhibition in spontaneous ovarian carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Tianli Zhou, Yunda Li, Heqiang Zhang, Lei Pan, Jinglong Pang, Qian Yuan, Guiyang Li, Lingjun Jie, Yan Wang, Yanhui Zhang
Summary: This study reveals the antiangiogenic role of DCPIB by targeting the VEGFR2 signaling pathway. DCPIB may be a valuable drug candidate for the treatment of angiogenesis-related diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Ning Zhong, Wei Zhuang, Qian Huang, Qiang Wang, Wenjian Jin
Summary: Apatinib inhibits the growth of SCLC cells by downregulating the expression of VEGF, pVEGFR2, p-PI3K, p-AKT, p-ERK1/2, Ki-67 and CD31.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ibukunoluwapo O. Zabroski, Matthew A. Nugent
Summary: This study investigated the role of lipid rafts in modulating non-activated VEGFR2 stability in endothelial cells. The results showed that disrupting lipid rafts decreased non-activated VEGFR2 levels and reduced VEGF activation of ERK.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Ade Meidian Ambari, Gracia Lilihata, Ervan Zuhri, Elok Ekawati, Shoma Adhi Wijaya, Bambang Dwiputra, Renan Sukmawan, Basuni Radi, Sofia Mubarika Haryana, Suko Adiarto, Dicky A. Hanafy, Dian Zamroni, Elen Elen, Arwin S. Mangkuanom, Anwar Santoso
Summary: The study showed that external counterpulsation improved angiogenesis by preserving VEGF-A and VEGFR-2 levels. Both ECP and sham significantly increased miR-92a levels, with no significant difference in changes between the two groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hyemi Kim, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim
Summary: The study demonstrates that DKK1 promotes angiogenesis and tumorigenesis in HCC by upregulating the VEGFR2-mediated mTOR/p70S6K signaling pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Mechanics
Jyotsana Priyadarshani, Prasoon Awasthi, Pratyaksh Karan, Soumen Das, Suman Chakraborty
Summary: This study presents a simulation mimicking tumor angiogenesis microenvironment on-chip, aiming to establish favorable conditions for gradients of vascular endothelial growth factor. The model platform explores different responses of endothelial cells in a micro-confined fluidic environment, showing potential significance for organ-on-a-chip assays, disease modeling, and optimizing anti-angiogenic therapies.
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Article
Ophthalmology
Jianqiang Lin, Kaixuan Cui, Yue Xu, Xiaoyu Tang, Yuxun Shi, Xi Lu, Boyu Yang, Qingjing He, Shanshan Yu, Xiaoling Liang
Summary: The study found that CD146 is involved in retinal neovascularization via the VEGFR2 pathway. Anti-CD146 may provide a new direction for the treatment of PDR and other ocular neovascular diseases.
ACTA OPHTHALMOLOGICA
(2022)
Article
Medicine, Research & Experimental
Chang Lu, Qiuyang Zhang, Huiying Zhang, Xiumiao Li, Qin Jiang, Jin Yao
Summary: Anlotinib has shown promise in inhibiting ocular neovascularization by reducing avascular areas and pathological neovascular tufts in animal models, suggesting its potential as a therapeutic candidate for eye diseases in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)