The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

(2020) Xindi Dang et al.   Cell Death & Disease

Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality

(2020) Santosh Shenoy   INFLAMMATION RESEARCH

RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus

(2020) Kevin E. Wu et al.   Cell Systems

Senescence and Host–Pathogen Interactions

(2020) Daniel Humphreys et al.   Cells

In vitro exposure of leukocytes to HIV pre-exposure prophylaxis (PrEP) decreases mitochondrial function and alters gene expression profiles.

(2020) Emily R. Bowman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic HBV or HCV, with or without HIV Co-Infection

(2020) Yevgeniy Gindin et al.   CLINICAL INFECTIOUS DISEASES

Cellular Senescence: Friend or Foe to Respiratory Viral Infections?

(2020) William J. Kelley et al.   EUROPEAN RESPIRATORY JOURNAL

Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway

(2020) Madison Schank et al.   Cell Death & Disease

Sequential trafficking of Env and Gag to HIV-1 T cell virological synapses revealed by live imaging

(2019) Lili Wang et al.   Retrovirology

Mitochondrial ROS generated at the complex-II matrix or intermembrane space microdomain have distinct effects on redox signaling and stress sensitivity in C. elegans.

(2019) Adam J Trewin et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: Randomized crossover clinical trial in healthy volunteers

(2019) Sergio Barroso et al.   PLoS One

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

(2019) Yingjie Ji et al.   Immunity & Ageing

Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions

(2019) Dechao Cao et al.   Frontiers in Immunology

Mitochondria as central hub of the immune system

(2019) Cristiane Naffah de Souza Breda et al.   Redox Biology

ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

(2019) Juan Zhao et al.   Frontiers in Immunology

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Clinical Pharmacology in HIV Therapy

(2018) Mohamed G. Atta et al.   Clinical Journal of the American Society of Nephrology

Nucleotide Reverse Transcriptase Inhibitors: A Thorough Review, Present Status and Future Perspective as HIV Therapeutics

(2018) Ashley D. Holec et al.   CURRENT HIV RESEARCH

Mitofusin 2: from functions to disease

(2018) Riccardo Filadi et al.   Cell Death & Disease

Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy

(2018) Duale Ahmed et al.   MEDIATORS OF INFLAMMATION

Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

(2018) Lam Nhat Nguyen et al.   Cell Death & Disease

Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians

(2018) Enzo Tedone et al.   AGING CELL

Endoplasmic reticulum stress leads to mitochondria-mediated apoptosis in cells treated with anti-HIV protease inhibitor ritonavir

(2018) Krishna Kumar Ganta et al.   CELL BIOLOGY AND TOXICOLOGY

Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy

(2017) Puja Van Epps et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Distinct Mitochondrial Disturbance in CD4+T and CD8+T Cells From HIV-Infected Patients

(2017) Fengting Yu et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Aging with HIV in the ART era

(2017) Emma Kaplan-Lewis et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Inflammation, Immune Activation, and Antiretroviral Therapy in HIV

(2017) Corrilynn O. Hileman et al.   Current HIV/AIDS Reports

Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections

(2017) K. K. Vidya Vijayan et al.   Frontiers in Immunology

Depolarization of mitochondrial membrane potential is the initial event in non-nucleoside reverse transcriptase inhibitor efavirenz induced cytotoxicity

(2016) Krishna Kumar Ganta et al.   CELL BIOLOGY AND TOXICOLOGY

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

High frequency of mitochondrial DNA mutations in HIV-infected treatment-experienced individuals

(2016) M Li et al.   HIV MEDICINE

Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure

(2016) Clovis S. Palmer et al.   JOURNAL OF IMMUNOLOGY

T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

(2016) Viviana Cobos Jiménez et al.   JOURNAL OF INFECTIOUS DISEASES

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

Human Immunodeficiency Virus (HIV)

(2016)   TRANSFUSION MEDICINE AND HEMOTHERAPY

Assessing immune aging in HIV-infected patients

(2016) Victor Appay et al.   Virulence

In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection

(2016) Kenneth M. Law et al.   Cell Reports

Enhanced Viral Replication by Cellular Replicative Senescence

(2016) Ji-Ae Kim et al.   Immune Network

Cell senescence is an antiviral defense mechanism

(2016) Maite Baz-Martínez et al.   Scientific Reports

Mitochondria: Are they causal players in cellular senescence?

(2015) Clara Correia-Melo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial DNA mutations in neurodegeneration

(2015) Michael J. Keogh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial dynamics and viral infections: A close nexus

(2015) Mohsin Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanisms linking mtDNA damage and aging

(2015) Milena Pinto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Shorter Telomere Length Predicts Poorer Immunological Recovery in Virologically Suppressed HIV-1–Infected Patients Treated With Combined Antiretroviral Therapy

(2015) José-Ramón Blanco et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells

(2015) Leonard Chavez et al.   PLoS Pathogens

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

(2015) Francesca Bonomini et al.   Aging and Disease

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

(2014) Noga Ron-Harel et al.   GERONTOLOGY

Antiretroviral Therapy

(2014) Alice K. Pau et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz

(2014) A. Blas-Garcia et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Respiratory Syncytial Virus Can Infect Basal Cells and Alter Human Airway Epithelial Differentiation

(2014) B. David Persson et al.   PLoS One

HIV protease inhibitors and onset of cardiovascular diseases: A central role for oxidative stress and dysregulation of the ubiquitin–proteasome system

(2013) Kathleen M.S.E. Reyskens et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

CD4+T-cell depletion in HIV infection: mechanisms of immunological failure

(2013) Afam A. Okoye et al.   IMMUNOLOGICAL REVIEWS

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

ER stress in human hepatic cells treated with Efavirenz: Mitochondria again

(2013) Nadezda Apostolova et al.   JOURNAL OF HEPATOLOGY

The end of AIDS: HIV infection as a chronic disease

(2013) Steven G Deeks et al.   LANCET

Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4+ T lymphocytes

(2013) Alessandro Comandini et al.   MOLECULAR IMMUNOLOGY

Role of Mitochondria in HIV Infection and Associated Metabolic Disorders: Focus on Nonalcoholic Fatty Liver Disease and Lipodystrophy Syndrome

(2013) P. Pérez-Matute et al.   Oxidative Medicine and Cellular Longevity

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes

(2012) Lara Gibellini et al.   AIDS

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV

(2012) Nathan W. Cummins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative Stress and Mitochondrial Impairment After Treatment with Anti-HIV Drugs: Clinical Implications

(2012) Ana Blas-Garcia et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondria Sentencing About Cellular Life and Death: A Matter of Oxidative Stress

(2012) Nadezda Apostolova et al.   CURRENT PHARMACEUTICAL DESIGN

The role of cytokines in the pathogenesis and treatment of HIV infection

(2012) Marta Catalfamo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

HIV and Mitochondria: More Than Just Drug Toxicity

(2012) T. Hulgan et al.   JOURNAL OF INFECTIOUS DISEASES

Unknown

(2012) Mudit Tyagi et al.   MOLECULAR MEDICINE

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HIV-1 Vpr Triggers Mitochondrial Destruction by Impairing Mfn2-Mediated ER-Mitochondria Interaction

(2012) Chih-Yang Huang et al.   PLoS One

HIV-1 Infection and First Line ART Induced Differential Responses in Mitochondria from Blood Lymphocytes and Monocytes: The ANRS EP45 “Aging” Study

(2012) Sophie Perrin et al.   PLoS One

In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

(2012) Kyle R. Hukezalie et al.   PLoS One

HIV-1 Induced Bystander Apoptosis

(2012) Himanshu Garg et al.   Viruses-Basel

The HIV-1 Env Protein: A Coat of Many Colors

(2012) Kathryn Twigg Arrildt et al.   Current HIV/AIDS Reports

Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training

(2011) Frederic Derbré et al.   AGE

Live-cell real-time imaging reveals role of mitochondria in cell-to-cell transmission of HIV-1

(2011) Sylvia Lee-Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial Toxicity in HAART: An Overview of In Vitro Evidence

(2011) Nadezda Apostolova et al.   CURRENT PHARMACEUTICAL DESIGN

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

Timing of the Components of the HIV Life Cycle in Productively Infected CD4+ T Cells in a Population of HIV-Infected Individuals

(2011) J. M. Murray et al.   JOURNAL OF VIROLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic intervention

(2011) Michael Kogan et al.   Retrovirology

Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition

(2011) Nadezda Apostolova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy

(2010) Stefania Piconi et al.   AIDS

Mitochondrial damage in adipose tissue of untreated HIV-infected patients

(2010) Glòria Garrabou et al.   AIDS

Enhanced oxidative stress and increased mitochondrial mass during Efavirenz-induced apoptosis in human hepatic cells

(2010) N Apostolova et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial metabolic function assessed in vivo and in vitro

(2010) Ian R Lanza et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

Revisiting HIV-1 uncoating

(2010) Nathalie Arhel   Retrovirology

HIV virology and pathogenetic mechanisms of infection: a brief overview

(2010) Emanuele Fanales-Belasio et al.   ANNALI DELL ISTITUTO SUPERIORE DI SANITA

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

(2009) Lydia W.S. Finley et al.   AGEING RESEARCH REVIEWS

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Non-nucleoside reverse transcriptase inhibitor efavirenz increases monolayer permeability of human coronary artery endothelial cells

(2009) Md Saha Jamaluddin et al.   ATHEROSCLEROSIS

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Mitochondrial membrane potential and apoptosis of blood mononuclear cells in untreated HIV-1 infected patients

(2009) T Sternfeld et al.   HIV MEDICINE

Lymphocyte Mitochondrial Depolarization and Apoptosis in HIV-1-Infected HAART Patients

(2009) Leshern Karamchand et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy

(2009) Antonella Mandas et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

HIV-1 viral genes and mitochondrial apoptosis

(2008) Devon J. Shedlock et al.   APOPTOSIS

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Mitochondrial DNA repair in aging and disease

(2008) Nadiya M. Druzhyna et al.   MECHANISMS OF AGEING AND DEVELOPMENT