HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic intervention

The functions of the HIV1 protein Vpr and its action through the DCAF1·DDB1·Cullin4 ubiquitin ligase

(2010) Laurieann Casey et al.   CYTOKINE

HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency

(2010) Shigeki Hoshino et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing

(2010) Will Fischer et al.   PLoS One

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

(2010) Evelyn M Kilareski et al.   Retrovirology

Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?

(2010) Diana Ayinde et al.   Retrovirology

Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R

(2010) Ge Li et al.   Retrovirology

Viral Genetic Determinants of Nonprogressive HIV Type 1 Subtype C Infection in Antiretroviral Drug-Naive Children

(2009) D.B. Tzitzivacos et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Inhibition of human immunodeficiency virus type 1 (HIV-1) nuclear import via Vpr–Importin α interactions as a novel HIV-1 therapy

(2009) Tatsunori Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing

(2009) J. Richard et al.   BLOOD

HIV-1 Viral Protein R (VPR) and its Interactions with Host Cell

(2009) Ge Li et al.   CURRENT HIV RESEARCH

Exogenous HIV-1 Vpr disrupts IFN-α response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay

(2009) Henoch Sangjoon Hong et al.   IMMUNOLOGY LETTERS

The Human Immunodeficiency Virus Type 2 Vpx Protein Usurps the CUL4A-DDB1DCAF1 Ubiquitin Ligase To Overcome a Postentry Block in Macrophage Infection

(2009) A. Bergamaschi et al.   JOURNAL OF VIROLOGY

Characterization of the Molecular Determinants of Primary HIV-1 Vpr Proteins: Impact of the Q65R and R77Q Substitutions on Vpr Functions

(2009) Guillaume Jacquot et al.   PLoS One

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

(2009) Jeffrey Ward et al.   PLoS Pathogens

CD163/CD16 Coexpression by Circulating Monocytes/Macrophages in HIV: Potential Biomarkers for HIV Infection and AIDS Progression

(2008) Tracy Fischer-Smith et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Infection with Vpr-Positive Human Immunodeficiency Virus Type 1 Impairs NK Cell Function Indirectly through Cytokine Dysregulation of Infected Target Cells

(2008) B. Majumder et al.   JOURNAL OF VIROLOGY

HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells

(2008) Paul E. Rosenstiel et al.   KIDNEY INTERNATIONAL

MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis

(2008) Jeffrey B Kopp et al.   NATURE GENETICS

Vpr14-88-Apobec3G Fusion Protein Is Efficiently Incorporated into Vif-Positive HIV-1 Particles and Inhibits Viral Infection

(2008) Zhujun Ao et al.   PLoS One

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy

(2008) Pauline Chugh et al.   Retrovirology

Direct Vpr-Vpr Interaction in Cells monitored by two Photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging

(2008) Joelle V Fritz et al.   Retrovirology

Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway

(2008) Pablo N Fernández Larrosa et al.   Retrovirology

Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor

(2008) Leon Caly et al.   Retrovirology

Activation of the glucocorticoid receptor releases unstimulated PBMCs from an early block in HIV-1 replication

(2008) Klaus Wiegers et al.   VIROLOGY

Primate Lentiviral Vpx Commandeers DDB1 to Counteract a Macrophage Restriction

(2008) Natalia Sharova et al.   PLoS Pathogens

Lentiviral Vpx Accessory Factor Targets VprBP/DCAF1 Substrate Adaptor for Cullin 4 E3 Ubiquitin Ligase to Enable Macrophage Infection

(2008) Smita Srivastava et al.   PLoS Pathogens