The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy

Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation

(2020) John Liddle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Resistance Mechanism of PD-1/PD-L1 Blockade in the Cancer-Immunity Cycle

(2020) Yuan Zhuang et al.   OncoTargets and Therapy

Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population

(2020) Chuanyin Li et al.   BMC CANCER

ERAP1: a potential therapeutic target for a myriad of diseases

(2020) Emma Reeves et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Melanoma immunotherapy: strategies to overcome pharmacological resistance

(2020) Claudia Trojaniello et al.   Expert Review of Anticancer Therapy

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

(2020) Alexandra Garancher et al.   NATURE NEUROSCIENCE

Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer

(2020) Sumit K. Subudhi et al.   Science Translational Medicine

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

(2020) Chloe Chong et al.   Nature Communications

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8+ T cell response in tumor

(2020) Yuan Wang et al.   Science Advances

MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma

(2020) Victor H Engelhard et al.   Journal for ImmunoTherapy of Cancer

Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies

(2020) Alberto Puccini et al.   Journal for ImmunoTherapy of Cancer

Acquired Resistance to Immune Checkpoint Blockade Therapies

(2020) Xianda Zhao et al.   Cancers

Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma

(2020) Hao Li et al.   Frontiers in Oncology

Extending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling

(2020) Sibylle Pfammatter et al.   ANALYTICAL CHEMISTRY

DRiPs get molecular

(2020) Jonathan W Yewdell et al.   CURRENT OPINION IN IMMUNOLOGY

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

(2020) Kristen E. Pauken et al.   Cell Reports

Uncovering the Tumor Antigen Landscape: What to Know about the Discovery Process

(2020) Sara Feola et al.   Cancers

HLA Class I Allele Expression and Clinical Outcome in De Novo Metastatic Prostate Cancer

(2020) Savvas Stokidis et al.   Cancers

PD-1 Immune Checkpoint Blockade Promotes Therapeutic Cancer Vaccine to Eradicate Lung Cancer

(2020) Pournima Kadam et al.   Vaccines

PD-L1 Expression Affects Neoantigen Presentation

(2020) Masahiro Okada et al.   iScience

Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy

(2020) Jumin Huang et al.   CURRENT OPINION IN PHARMACOLOGY

The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

(2020) Dimitris Georgiadis et al.   Frontiers in Pharmacology

Antigen processing and presentation in cancer immunotherapy

(2020) Maxwell Y Lee et al.   Journal for ImmunoTherapy of Cancer

Identification of microRNAs Targeting the Transporter Associated with Antigen Processing TAP1 in Melanoma

(2020) Maria-Filothei Lazaridou et al.   Journal of Clinical Medicine

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

On the Other Side: Manipulating the Immune Checkpoint Landscape of Dendritic Cells to Enhance Cancer Immunotherapy

(2019) Benjamin Y. Kong et al.   Frontiers in Oncology

21-Gene Recurrence Score Assay and Outcomes of Adjuvant Radiotherapy in Elderly Women With Early-Stage Breast Cancer After Breast-Conserving Surgery

(2019) San-Gang Wu et al.   Frontiers in Oncology

Neoantigen-directed immune escape in lung cancer evolution

(2019) Rachel Rosenthal et al.   NATURE

Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance

(2019) Yaqi Li et al.   IMMUNOLOGY LETTERS

Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer

(2019) Mirco Compagnone et al.   HUMAN IMMUNOLOGY

Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer

(2019) A B Schrock et al.   ANNALS OF ONCOLOGY

MHC class-I downregulation in PD-1/PD-L1 inhibitor refractory Merkel cell carcinoma and its potential reversal by histone deacetylase inhibition: a case series

(2019) Selma Ugurel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

TEIPP peptides: exploration of unTAPped cancer antigens

(2019) Koen A. Marijt et al.   OncoImmunology

Long Noncoding RNA HCP5, a Hybrid HLA Class I Endogenous Retroviral Gene: Structure, Expression, and Disease Associations

(2019) Jerzy K. Kulski   Cells

Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)

(2019) Despoina Koumantou et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

(2019) Alex M. Jaeger et al.   CLINICAL CANCER RESEARCH

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

(2019) Giuseppe Rospo et al.   Genome Medicine

Tumor mutational burden as a predictive biomarker for checkpoint inhibitor immunotherapy

(2019) Mark Lee et al.   Human Vaccines & Immunotherapeutics

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC

(2019) Emma Reeves et al.   Cancer Immunology Research

Association Between Tumor Mutation Burden (TMB) and Outcomes of Cancer Patients Treated With PD-1/PD-L1 Inhibitions: A Meta-Analysis

(2019) Jiaxin Zhu et al.   Frontiers in Pharmacology

High tumor mutation burden predicts better efficacy of immunotherapy: a pooled analysis of 103078 cancer patients

(2019) Dedong Cao et al.   OncoImmunology

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

(2019) Marian L. Burr et al.   CANCER CELL

Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression

(2019) Barry A. Kriegsman et al.   JOURNAL OF IMMUNOLOGY

Tumor mutational burden assessed by targeted NGS predicts clinical benefit from immune checkpoint inhibitors in non‐small cell lung cancer

(2019) Ilaria Alborelli et al.   JOURNAL OF PATHOLOGY

Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion

(2019) Reshmi Tripathi et al.   OncoImmunology

The prognostic significance of peritumoral tertiary lymphoid structures in breast cancer

(2019) Michael Sofopoulos et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer immune escape: MHC expression in primary tumours versus metastases

(2019) Federico Garrido et al.   IMMUNOLOGY

The Human Immunopeptidome Project: a roadmap to predict and treat immune diseases

(2019) Juan Antonio Vizcaíno et al.   MOLECULAR & CELLULAR PROTEOMICS

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

(2019) Shuang Qin et al.   Molecular Cancer

Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens

(2019) Gerald P. Linette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

(2019) Shixiang Wang et al.   eLife

The balance between breast cancer and the immune system: Challenges for prognosis and clinical benefit from immunotherapies

(2019) Constantin N. Baxevanis et al.   SEMINARS IN CANCER BIOLOGY

The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma†

(2018) Michelle D Warthan et al.   BIOLOGY OF REPRODUCTION

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

(2018) Matthew D. Hellmann et al.   CANCER CELL

Mapping the HLA ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

(2018) Markus W. Löffler et al.   CANCER RESEARCH

The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

(2018) Lu Huang et al.   CLINICAL CANCER RESEARCH

Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application

(2018) Dimitris Georgiadis et al.   CURRENT MEDICINAL CHEMISTRY

The transition from HLA-I positive to HLA-I negative primary tumors: the road to escape from T-cell responses

(2018) Natalia Aptsiauri et al.   CURRENT OPINION IN IMMUNOLOGY

Hypermutated Tumors and Immune Checkpoint Inhibition

(2018) Kristen K. Ciombor et al.   DRUGS

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I

(2018) Najla Arshad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MHC class I presented antigens from malignancies: A perspective on analytical characterization & immunogenicity

(2018) Maike Schmidt et al.   Journal of Proteomics

Dysfunction of antigen processing and presentation by dendritic cells in cancer

(2018) Joanna Bandola-Simon et al.   MOLECULAR IMMUNOLOGY

TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I low cancers

(2018) Koen A. Marijt et al.   MOLECULAR IMMUNOLOGY

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

(2018) Theo A. Knijnenburg et al.   Cell Reports

Epigenetic mechanisms of tumor resistance to immunotherapy

(2018) Natalia Arenas-Ramirez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of non-mutated neoantigens presented by TAP-deficient tumors

(2018) Koen A. Marijt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome

(2018) Roman Mylonas et al.   MOLECULAR & CELLULAR PROTEOMICS

Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules

(2018) F. Tudor Ilca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

(2018) Jennifer Ma et al.   Nature Communications

RNA editing derived epitopes function as cancer antigens to elicit immune responses

(2018) Minying Zhang et al.   Nature Communications

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma

(2018) Christof C. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

(2018) Yoong Wearn Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

(2018) Razvan Cristescu et al.   SCIENCE

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

(2018) José A. López de Castro   Frontiers in Immunology

Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade

(2018) Wassim Abida et al.   JAMA Oncology

Melanoma: a prototype of cancer-testis antigen-expressing malignancies

(2017) Sepideh Faramarzi et al.   Immunotherapy

Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity

(2017) Andrés Alloatti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

(2017) Stefan B. Eichmüller et al.   JNCI-Journal of the National Cancer Institute

Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

(2017) Samra Turajlic et al.   LANCET ONCOLOGY

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

(2017) Michael J Overman et al.   LANCET ONCOLOGY

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

(2017) Aaron M. Goodman et al.   MOLECULAR CANCER THERAPEUTICS

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

(2017) Giovanni Germano et al.   NATURE

Structure of the human MHC-I peptide-loading complex

(2017) Andreas Blees et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

First-Line Nivolumab in Stage IV or Recurrent Non–Small-Cell Lung Cancer

(2017) David P. Carbone et al.   NEW ENGLAND JOURNAL OF MEDICINE

The immunopeptidomic landscape of ovarian carcinomas

(2017) Heiko Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

(2017) Udupi A. Ramagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

HLA-mediated tumor escape mechanisms that may impair immunotherapy clinical outcomes via T-cell activation

(2017) Josefa A. Rodríguez   Oncology Letters

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

(2017) Filippo Veglia et al.   Nature Communications

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma

(2017) Aditi Qamra et al.   Cancer Discovery

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

(2017) Scott Gettinger et al.   Cancer Discovery

A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and "pan-leukemia" antigens

(2017) Linus Backert et al.   Oncotarget

Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells

(2017) I-Chun Kuo et al.   Oncotarget

The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy

(2017) Daniel Zingg et al.   Cell Reports

Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

(2017) Anita Sveen et al.   Genome Medicine

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

(2017) Zachary R. Chalmers et al.   Genome Medicine

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

(2017) Stefan B. Eichmüller et al.   JNCI-Journal of the National Cancer Institute

TAP1 down-regulation elicits immune escape and poor prognosis in colorectal cancer

(2017) Agnes Ling et al.   OncoImmunology

Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition

(2017) Yosuke Shionoya et al.   OncoImmunology

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

(2017) Cathrin Ritter et al.   Scientific Reports

Tumor mutation load assessed by FoundationOne (FM1) is associated with improved efficacy of atezolizumab (atezo) in patients with advanced NSCLC

(2016) M. Kowanetz et al.   ANNALS OF ONCOLOGY

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

Mutanome directed cancer immunotherapy

(2016) Mathias Vormehr et al.   CURRENT OPINION IN IMMUNOLOGY

Mass spectrometry-based antigen discovery for cancer immunotherapy

(2016) Michal Bassani-Sternberg et al.   CURRENT OPINION IN IMMUNOLOGY

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

The role of neoantigens in response to immune checkpoint blockade

(2016) Nadeem Riaz et al.   INTERNATIONAL IMMUNOLOGY

ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules

(2016) Niranjana A. Nagarajan et al.   JOURNAL OF IMMUNOLOGY

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing

(2016) Giora I. Morozov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

(2016) Sayuri Yoshihama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

(2016) Juliane Liepe et al.   SCIENCE

Dendritic Cells and Cancer Immunity

(2016) Alycia Gardner et al.   TRENDS IN IMMUNOLOGY

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

(2016) Céline M. Laumont et al.   Nature Communications

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

(2016) Valsamo Anagnostou et al.   Cancer Discovery

Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade

(2016) D. B. Johnson et al.   Cancer Immunology Research

ERAP1 Regulates Natural Killer Cell Function by Controlling the Engagement of Inhibitory Receptors

(2015) L. Cifaldi et al.   CANCER RESEARCH

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

(2015) Michael S. Rooney et al.   CELL

Acquisition and Presentation of Tumor Antigens by Dendritic Cells

(2015) Irene Bonaccorsi et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35-specific T-cell recognition

(2015) Martin Keller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Multiple Structural and Epigenetic Defects in the Human Leukocyte Antigen Class I Antigen Presentation Pathway in a Recurrent Metastatic Melanoma Following Immunotherapy

(2015) Chien-Chung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Landscape of Tumor Antigens in T Cell Immunotherapy

(2015) S. Ilyas et al.   JOURNAL OF IMMUNOLOGY

3,4-Diaminobenzoic Acid Derivatives as Inhibitors of the Oxytocinase Subfamily of M1 Aminopeptidases with Immune-Regulating Properties

(2015) Athanasios Papakyriakou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loss of tapasin correlates with diminished CD8+ T-cell immunity and prognosis in colorectal cancer

(2015) Lena Sokol et al.   Journal of Translational Medicine

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

(2015) A. R. Sanchez-Paulete et al.   Cancer Discovery

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma

(2015) S. D. Bradley et al.   Cancer Immunology Research

MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In Vitro

(2014) T. E. Angell et al.   CLINICAL CANCER RESEARCH

CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire

(2014) L. Robert et al.   CLINICAL CANCER RESEARCH

Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy

(2014) Alison M. McDonnell et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Correction: Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency

(2014) Irini Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response

(2014) P. Kvistborg et al.   Science Translational Medicine

Modulating antigen processing for cancer immunotherapy

(2014) Efstratios Stratikos   OncoImmunology

A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-Disposition

(2014) Efstratios Stratikos et al.   Frontiers in Oncology

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

(2013) Hyunsoo Chung et al.   BIOMARKERS

Harnessing the antigenic fingerprint of each individual cancer for immunotherapy of human cancer: genomics shows a new way and its challenges

(2013) Pramod K. Srivastava et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Blockade of PD-1/PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast cancer in hu-SCID mice

(2013) Yan Ge et al.   CANCER LETTERS

Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions

(2013) Sarah E. Henrickson et al.   IMMUNITY

Safety, Efficacy, and Biomarkers of Nivolumab With Vaccine in Ipilimumab-Refractory or -Naive Melanoma

(2013) Jeffrey S. Weber et al.   JOURNAL OF CLINICAL ONCOLOGY

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function

(2013) E. James et al.   JOURNAL OF IMMUNOLOGY

Immune surveillance for ERAAP dysfunction

(2013) Niranjana A. Nagarajan et al.   MOLECULAR IMMUNOLOGY

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

(2013) J. Nangalia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

(2013) E. Zervoudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells in the Cancer Microenvironment

(2013) Yang Ma et al.   Journal of Cancer

Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

(2013) M. J. Selby et al.   Cancer Immunology Research

Tumor-Altered Dendritic Cell Function: Implications for Anti-Tumor Immunity

(2013) Kristian M. Hargadon   Frontiers in Immunology

Role of non-classical MHC class I molecules in cancer immunosuppression

(2013) Grazyna Kochan et al.   OncoImmunology

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Antibody-Based Immunotherapy of Cancer

(2012) Louis M. Weiner et al.   CELL

Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases

(2012) S. Viganò et al.   Clinical & Developmental Immunology

Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer

(2012) Loredana Cifaldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ovarian cancer progression is controlled by phenotypic changes in dendritic cells

(2012) Uciane K. Scarlett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells

(2012) Irene Romero et al.   JOURNAL OF PATHOLOGY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Expression of tumour-specific antigens underlies cancer immunoediting

(2012) Michel DuPage et al.   NATURE

Nonclassical MHC class Ib–restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum

(2012) Niranjana A Nagarajan et al.   NATURE IMMUNOLOGY

Post-Transcriptional and Epigenetic Regulation of Antigen Processing Machinery (APM) Components and HLA-I in Cervical Cancers from Uighur Women

(2012) Ayshamgul Hasim et al.   PLoS One

A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens

(2011) Ursula J. E. Seidel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

(2011) L. Cifaldi et al.   CANCER RESEARCH

Different Expression Levels of the TAP Peptide Transporter Lead to Recognition of Different Antigenic Peptides by Tumor-Specific CTL

(2011) A. Durgeau et al.   JOURNAL OF IMMUNOLOGY

PD-1 Blockade by CT-011, Anti-PD-1 Antibody, Enhances Ex Vivo T-cell Responses to Autologous Dendritic Cell/Myeloma Fusion Vaccine

(2011) Jacalyn Rosenblatt et al.   JOURNAL OF IMMUNOTHERAPY

The Human Immunopeptidome Project, a Suggestion for yet another Postgenome Next Big Thing

(2011) Arie Admon et al.   MOLECULAR & CELLULAR PROTEOMICS

The biology of cancer testis antigens: Putative function, regulation and therapeutic potential

(2011) Elisabetta Fratta et al.   Molecular Oncology

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

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Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

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CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

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