Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections

(2014) C. F. Towne et al.   JOURNAL OF IMMUNOLOGY

Novel selective inhibitors of aminopeptidases that generate antigenic peptides

(2013) Athanasios Papakyriakou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function

(2013) E. James et al.   JOURNAL OF IMMUNOLOGY

Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies

(2013) Efstratios Stratikos et al.   MOLECULAR IMMUNOLOGY

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

(2012) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Nonclassical MHC class Ib–restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum

(2012) Niranjana A Nagarajan et al.   NATURE IMMUNOLOGY

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

(2011) Efthalia Zervoudi et al.   BIOCHEMICAL JOURNAL

The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing

(2011) James R. Birtley et al.   BIOCHEMISTRY

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

(2011) L. Cifaldi et al.   CANCER RESEARCH

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection

(2010) R. Cagliani et al.   HUMAN MOLECULAR GENETICS

Placental Leucine Aminopeptidase Efficiently Generates Mature Antigenic Peptides In Vitro but in Patterns Distinct from Endoplasmic Reticulum Aminopeptidase 1

(2010) D. Georgiadou et al.   JOURNAL OF IMMUNOLOGY

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

(2010) Liang-Dan Sun et al.   NATURE GENETICS

Endoplasmic reticulum aminopeptidases: biology and pathogenic potential

(2010) Nigil Haroon et al.   Nature Reviews Rheumatology

A continuous fluorigenic assay for the measurement of the activity of endoplasmic reticulum aminopeptidase 1: Competition kinetics as a tool for enzyme specificity investigation

(2009) Irini Evnouchidou et al.   ANALYTICAL BIOCHEMISTRY

A New Role for Zn(II) Aminopeptidases: Antigenic Peptide Generation and Destruction

(2009) Irini Evnouchidou et al.   CURRENT PHARMACEUTICAL DESIGN

Cytosolic Aminopeptidases Influence MHC Class I-Mediated Antigen Presentation in an Allele-Dependent Manner

(2009) E. Kim et al.   JOURNAL OF IMMUNOLOGY

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

(2009) Stefan Tenzer et al.   NATURE IMMUNOLOGY

Different cross-presentation pathways in steady-state and inflammatory dendritic cells

(2009) E. Segura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

Coping with loss of perfection in the MHC class I peptide repertoire

(2008) Nicolas Blanchard et al.   CURRENT OPINION IN IMMUNOLOGY

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

(2008) Anthony L. Albiston et al.   FASEB JOURNAL

Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum

(2008) Nicolas Blanchard et al.   NATURE IMMUNOLOGY

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

(2008) Irini Evnouchidou et al.   PLoS One