Journal
MOLECULAR IMMUNOLOGY
Volume 113, Issue -, Pages 31-37Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2018.03.025
Keywords
Antigen processing and presentation; Cancer
Categories
Funding
- Intramural Research Program of the National Cancer Institute
- NATIONAL CANCER INSTITUTE [ZIABC011687, ZIABC009404, ZIABC011033] Funding Source: NIH RePORTER
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The ability to mount an effective anti-tumor immune response requires coordinate control of CD4 T cell and CD8 T cell function by antigen presenting cells (APCs). Unfortunately, tumors create an immunosuppressive microenvironment that helps protect tumor cells from immune recognition. In many cases this defect can be traced back to a failure of APCs (most importantly dendritic cells (DCs)) to recognize, process, and present tumor antigens to T cells. In this review, we will summarize work addressing the role of different DC subsets in anti-tumor immunity and the various mechanisms used by tumor cells to suppress the ability of APCs to stimulate potent anti-tumor T cell responses.
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