Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson’s disease and their targeted therapeutic approaches: a comprehensive review

Precision medicine in Parkinson’s disease: emerging treatments for genetic Parkinson’s disease

(2020) Susanne A. Schneider et al.   JOURNAL OF NEUROLOGY

Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies

(2020) Tatiana Orme et al.   Acta Neuropathologica Communications

Dysregulation of the Gut-Brain Axis, Dysbiosis and Influence of numerous factors on Gut Microbiota associated Parkinson’s Disease

(2020) Gagandeep Kaur et al.   Current Neuropharmacology

Nutraceuticals in Neurological Disorders

(2020) Rashita Makkar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of a pathogenic variant in GBA for Parkinson’s disease with mild cognitive impairment patients

(2020) Zhiqiang Jiang et al.   Molecular Brain

Dementia with Lewy bodies: an update and outlook

(2019) Tiago Fleming Outeiro et al.   Molecular Neurodegeneration

The distribution and risk effect of GBA variants in a large cohort of PD patients from Colombia and Peru

(2019) Carlos Velez-Pardo et al.   PARKINSONISM & RELATED DISORDERS

GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic Approaches

(2019) Giulietta M. Riboldi et al.   Cells

The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease

(2019) Lena F. Burbulla et al.   NEUROBIOLOGY OF DISEASE

Is Parkinson’s disease a lysosomal disorder?

(2018) Andrés D Klein et al.   BRAIN

GBA-Associated Parkinson’s Disease and Other Synucleinopathies

(2018) Ziv Gan-Or et al.   Current Neurology and Neuroscience Reports

Parkinson's disease: A review

(2018) Vinay Goyal et al.   NEUROLOGY INDIA

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

(2018) Friederike Zunke et al.   NEURON

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

(2018) Sangjune Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

(2018) Xian-Si Zeng et al.   Frontiers in Aging Neuroscience

Exploring genetic modifiers of Gaucher disease: The next horizon

(2018) Brad A. Davidson et al.   HUMAN MUTATION

Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels

(2018) Anna Lisa Gündner et al.   NEUROBIOLOGY OF DISEASE

A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease

(2018) Yuan Zhang et al.   Parkinsons Disease

Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine

(2018) Fabio Blandini et al.   MOVEMENT DISORDERS

Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis

(2018) Michaela E. Johnson et al.   TRENDS IN NEUROSCIENCES

The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase

(2018) Cathrine K. Fog et al.   EBioMedicine

Gaucher disease: Progress and ongoing challenges

(2017) Pramod K. Mistry et al.   MOLECULAR GENETICS AND METABOLISM

The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection

(2017) Parvana Hajieva   MOLECULES

A “dose” effect of mutations in the GBA gene on Parkinson's disease phenotype

(2017) Avner Thaler et al.   PARKINSONISM & RELATED DISORDERS

Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate

(2017) Anna Migdalska-Richards et al.   SYNAPSE

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice

(2016) Anna Migdalska-Richards et al.   ANNALS OF NEUROLOGY

Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's

(2016) Ganqiang Liu et al.   ANNALS OF NEUROLOGY

Survival and dementia inGBA-associated Parkinson's disease: The mutation matters

(2016) Roberto Cilia et al.   ANNALS OF NEUROLOGY

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease

(2016) Joana Magalhaes et al.   HUMAN MOLECULAR GENETICS

Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links

(2016) Tim Moors et al.   MOVEMENT DISORDERS

The GBA , DYRK1A and MS4A6A polymorphisms influence the age at onset of Chinese Parkinson patients

(2016) Kuan Fan et al.   NEUROSCIENCE LETTERS

Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson’s Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations

(2016) Olga Momcilovic et al.   PLoS One

Implication of oxidative stress in progression of diabetic retinopathy

(2016) Tapan Behl et al.   SURVEY OF OPHTHALMOLOGY

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

(2016) Alvaro Sanchez-Martinez et al.   Scientific Reports

Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C

(2015) James M. Gruschus et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucocerebrosidase 1 deficientDanio reriomirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

(2015) Marcus Keatinge et al.   HUMAN MOLECULAR GENETICS

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

(2015) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Oligomeric Alpha-Synuclein Is Associated With Glucocerebrosidase Activity in Gaucher Disease

(2015) Evgenii Nuzhnyi et al.   MOVEMENT DISORDERS

Polygenic determinants of Parkinson's disease in a Chinese population

(2015) Ji-Feng Guo et al.   NEUROBIOLOGY OF AGING

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells

(2015) Giulia Ambrosi et al.   NEUROBIOLOGY OF DISEASE

Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease

(2015) James M. Gruschus   PLoS One

Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle

(2015) S. Pablo Sardi et al.   PROGRESS IN NEUROBIOLOGY

Effect ofGBAMutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and aMeta-Analysis

(2015) Yuan Zhang et al.   Parkinsons Disease

Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation

(2014) Ianai Fishbein et al.   BRAIN

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

(2014) Alisdair McNeill et al.   BRAIN

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

Structural Features of Membrane-bound Glucocerebrosidase and α-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy

(2014) Thai Leong Yap et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP13A2/PARK9 Regulates Secretion of Exosomes and  -Synuclein

(2014) T. Tsunemi et al.   JOURNAL OF NEUROSCIENCE

Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein

(2014) Eun-Jin Bae et al.   Nature Communications

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

(2014) Chris M. Woodard et al.   Cell Reports

Saposin C Protects Glucocerebrosidase against α-Synuclein Inhibition

(2013) Thai Leong Yap et al.   BIOCHEMISTRY

Immortality of cell lines: challenges and advantages of establishment

(2013) Muhammad Irfan Maqsood et al.   CELL BIOLOGY INTERNATIONAL

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases

(2013) Mary J. Holmay et al.   CLINICAL NEUROPHARMACOLOGY

Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

(2013) Taiji Tsunemi et al.   HUMAN MOLECULAR GENETICS

Gaucher disease: Chemotactic factors and immunological cell invasion in a mouse model

(2013) Manoj Kumar Pandey et al.   MOLECULAR GENETICS AND METABOLISM

The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease

(2013) Z. Gan-Or et al.   NEUROLOGY

Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis

(2013) Alisdair McNeill et al.   PLoS One

Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease: Fig. 1.

(2013) Anthony H. V. Schapira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones

(2013) C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs WithoutGBAMutations

(2013) Lama M. Chahine et al.   JAMA Neurology

Glucocerebrosidase L444P mutation confers genetic risk for Parkinson’s disease in central China

(2012) Youpei Wang et al.   Behavioral and Brain Functions

Pilot study using ambroxol as a pharmacological chaperone in type 1 Gaucher disease

(2012) Ari Zimran et al.   BLOOD CELLS MOLECULES AND DISEASES

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

(2012) Henryk Kozlowski et al.   COORDINATION CHEMISTRY REVIEWS

Age-specific Parkinson disease risk in GBA mutation carriers: information for genetic counseling

(2012) Huma Q. Rana et al.   GENETICS IN MEDICINE

A clinical and family history study of Parkinson's disease in heterozygousglucocerebrosidasemutation carriers

(2012) Alisdair McNeill et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

The role of saposin C in Gaucher disease

(2012) Rafael J. Tamargo et al.   MOLECULAR GENETICS AND METABOLISM

Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity

(2012) Thai Leong Yap et al.   MOLECULAR GENETICS AND METABOLISM

Hyposmia and cognitive impairment in Gaucher disease patients and carriers

(2012) Alisdair McNeill et al.   MOVEMENT DISORDERS

Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers

(2012) M. Anheim et al.   NEUROLOGY

Cognitive performance of GBA mutation carriers with early-onset PD: The CORE-PD study

(2012) R. N. Alcalay et al.   NEUROLOGY

Association of mutations in the glucocerebrosidase gene with Parkinson disease in a Korean population

(2012) Jung Mi Choi et al.   NEUROSCIENCE LETTERS

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

The enigma of the E326K mutation in acid β-glucocerebrosidase

(2011) Mia Horowitz et al.   MOLECULAR GENETICS AND METABOLISM

Glucocerebrosidase gene mutations are associated with Parkinson's disease in Russia

(2011) Anton Emelyanov et al.   MOVEMENT DISORDERS

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Mutations in the glucocerebrosidase gene confer a risk for Parkinson disease in North Africa

(2011) S. Lesage et al.   NEUROLOGY

Glucocerebrosidase N370S and L444P mutations as risk factors for Parkinson’s disease in Brazilian patients

(2011) Beatriz de Carvalho Guimarães et al.   PARKINSONISM & RELATED DISORDERS

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNS expression of glucocerebrosidase corrects  -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

(2011) S. P. Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The incidence of Parkinsonism in patients with type 1 Gaucher disease: Data from the ICGG Gaucher Registry

(2010) Barry Rosenbloom et al.   BLOOD CELLS MOLECULES AND DISEASES

The risk of Parkinson’s disease in type 1 Gaucher disease

(2010) Gilberto Bultron et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Glucocerebrosidase Gene L444P mutation is a risk factor for Parkinson's disease in Chinese population

(2010) Qi-Ying Sun et al.   MOVEMENT DISORDERS

Gaucher disease ascertained through a Parkinson's center: Imaging and clinical characterization

(2010) Rachel Saunders-Pullman et al.   MOVEMENT DISORDERS

Mutations for Gaucher Disease Confer High Susceptibility to Parkinson Disease

(2009) Jun Mitsui et al.   ARCHIVES OF NEUROLOGY

Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

(2009) Latha Devi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

Acid β-Glucosidase 1 Counteracts p38δ-dependent Induction of Interleukin-6

(2009) Kazuyuki Kitatani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Greece

(2009) Kallirhoe Kalinderi et al.   NEUROSCIENCE LETTERS

Genetic susceptibility in Parkinson's disease

(2008) Jose Miguel Bras et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular basis of multiple sulfatase deficiency, mucolipidosis II/III and Niemann–Pick C1 disease — Lysosomal storage disorders caused by defects of non-lysosomal proteins

(2008) Thomas Dierks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

(2008) Jose Bras et al.   FEBS Journal

Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)

(2008) Kathleen S. Hruska et al.   HUMAN MUTATION

Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset

(2008) W. C. Nichols et al.   NEUROLOGY

Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset

(2008) Z. Gan-Or et al.   NEUROLOGY

Glucocerebrosidase gene mutations are associated with Parkinson's disease in southern Italy

(2007) Elvira V. De Marco et al.   MOVEMENT DISORDERS

Association between Parkinson's disease and glucocerebrosidase mutations in Brazil

(2007) Mariana Spitz et al.   PARKINSONISM & RELATED DISORDERS