The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection

Mechanisms of neuronal homeostasis: Autophagy in the axon

(2016) Sandra Maday   BRAIN RESEARCH

Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology

(2016) Daniela Pantano et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Rutin as a Natural Therapy for Alzheimer’s Disease: Insights into its Mechanisms of Action

(2016) Solomon Habtemariam   CURRENT MEDICINAL CHEMISTRY

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

(2016) Santa Cirmi et al.   MOLECULES

Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases

(2015) Niki Chondrogianni et al.   AGEING RESEARCH REVIEWS

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Membrane protein oxidation determines neuronal degeneration

(2015) Parvana Hajieva et al.   JOURNAL OF NEUROCHEMISTRY

Polyphenols for the prevention and treatment of dementia diseases

(2015) HelmutM Hügel et al.   Neural Regeneration Research

Molecular chaperones and neuronal proteostasis

(2015) Heather L. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

High membrane protein oxidation in the human cerebral cortex

(2015) Matthias Granold et al.   Redox Biology

Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents

(2014) Akira Murakami   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

TheGinkgo bilobaExtract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation

(2014) Marcel Stark et al.   Evidence-based Complementary and Alternative Medicine

(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy

(2014) Diana Macedo et al.   HUMAN MOLECULAR GENETICS

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Amyloid-beta (Aβ1-42)-induced paralysis inCaenorhabditis elegansis inhibited by the polyphenol quercetin through activation of protein degradation pathways

(2014) Charlotte Regitz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

Quercetin alleviates high glucose-induced Schwann cell damage by autophagy

(2014) Ling Qu et al.   Neural Regeneration Research

Structural Biology of the Proteasome

(2013) Erik Kish-Trier et al.   Annual Review of Biophysics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Thinking laterally about neurodegenerative proteinopathies

(2013) Todd E. Golde et al.   JOURNAL OF CLINICAL INVESTIGATION

Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both  -Amyloid Production and Clearance

(2013) Z. Zhu et al.   JOURNAL OF NEUROSCIENCE

Protein oxidation in aging and the removal of oxidized proteins

(2013) Annika Höhn et al.   Journal of Proteomics

Protein Quality Control System in Neurodegeneration: A Healing Company Hard to Beat but Failure is Fatal

(2013) Deepak Chhangani et al.   MOLECULAR NEUROBIOLOGY

Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts

(2013) Alexzander Asea et al.   PHYTOMEDICINE

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants?

(2012) Maike J. Ohlow et al.   FEBS LETTERS

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

(2012) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Effects of natural antioxidants in neurodegenerative disease

(2012) Sonia Luz Albarracin et al.   NUTRITIONAL NEUROSCIENCE

The Parkinson disease protein α-synuclein inhibits autophagy

(2011) Ashley R. Winslow et al.   Autophagy

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Chemical analysis of Greek pollen - Antioxidant, antimicrobial and proteasome activation properties

(2011) Konstantia Graikou et al.   Chemistry Central Journal

Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations

(2011) Sebastian Schaffer et al.   Genes and Nutrition

Gambogic Acid, a Natural Product Inhibitor of Hsp90

(2011) Jason Davenport et al.   JOURNAL OF NATURAL PRODUCTS

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding

(2010) Lap Ho et al.   Expert Review of Proteomics

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration

(2010) Yousuf O. Ali et al.   MOLECULES

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of heat shock response by curcumin in human leukemia cells

(2009) Marie-Hélène Teiten et al.   CANCER LETTERS

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Consuming a Diet Supplemented with Resveratrol Reduced Infection-Related Neuroinflammation and Deficits in Working Memory in Aged Mice

(2009) Jayne Abraham et al.   REJUVENATION RESEARCH

Grape Extract Protects Mitochondria from Oxidative Damage and Improves Locomotor Dysfunction and Extends Lifespan in a Drosophila Parkinson's Disease Model

(2009) Jiangang Long et al.   REJUVENATION RESEARCH

Green tea catechin as a chemical chaperone in cancer prevention

(2008) Takashi Kuzuhara et al.   CANCER LETTERS

Structure of the Human 26S Proteasome

(2008) Paula C. A. da Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity

(2008) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

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(2008) G Irvine et al.   MOLECULAR MEDICINE

Resveratrol Induces the Heat-Shock Response and Protects Human Cells from Severe Heat Stress

(2007) Ákos Putics et al.   ANTIOXIDANTS & REDOX SIGNALING