An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

(2020) Hend Abdelrasoul et al.   Nature Communications

Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands

(2020) Mirja Harms et al.   Scientific Reports

The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases

(2019) Eva M. García-Cuesta et al.   Frontiers in Endocrinology

Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018

(2019) Yesim A Tahirovic et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

CXCR4 involvement in neurodegenerative diseases

(2018) Luke W. Bonham et al.   Translational Psychiatry

Dupilumab progressively improves systemic and cutaneous abnormalities in atopic dermatitis patients

(2018) Emma Guttman-Yassky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophils Target Therapy for Severe Asthma: Critical Points

(2018) L. Brussino et al.   Biomed Research International

A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis

(2017) Z Xiang et al.   ONCOGENE

Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD

(2016) J A Müller et al.   BONE MARROW TRANSPLANTATION

CXCR4 signaling in health and disease

(2016) Tommaso Pozzobon et al.   IMMUNOLOGY LETTERS

Proteolytic processing of human serum albumin generates EPI-X4, an endogenous antagonist of CXCR4

(2016) Onofrio Zirafi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Atopic dermatitis

(2016) Stephan Weidinger et al.   LANCET

CXCR4 inhibitor attenuates ovalbumin-induced airway inflammation and hyperresponsiveness by inhibiting Th17 and Tc17 cell immune response

(2016) HUILONG CHEN et al.   Experimental and Therapeutic Medicine

CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation

(2015) Susana Cavallero et al.   DEVELOPMENTAL CELL

Eosinophils in mucosal immune responses

(2015) J Travers et al.   Mucosal Immunology

EPI-X4, a novel endogenous antagonist of CXCR4

(2015) Christian Buske et al.   Oncotarget

Discovery and Characterization of an Endogenous CXCR4 Antagonist

(2015) Onofrio Zirafi et al.   Cell Reports

In vivozebrafish assays for analyzing drug toxicity

(2014) Demetrio Raldúa et al.   Expert Opinion on Drug Metabolism & Toxicology

An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation

(2014) Silvana Zgraggen et al.   PLoS One

An Antedrug of the CXCL12 Neutraligand Blocks Experimental Allergic Asthma without Systemic Effect in Mice

(2013) François Daubeuf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR4 Negatively Regulates Keratinocyte Proliferation in IL-23-Mediated Psoriasiform Dermatitis

(2013) Tomonori Takekoshi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents

(2011) M. G. Morash et al.   Disease Models & Mechanisms

Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

(2011) Vincent Gasparik et al.   ACS Medicinal Chemistry Letters

Chemokine (C-X-C Motif) Ligand 12/Stromal Cell-Derived Factor-1 Is Associated With Leukocyte Recruitment in Asthma

(2010) María Cristina Negrete-García et al.   CHEST

Modulating progenitor accumulation attenuates lung angiogenesis in a mouse model of asthma

(2010) T. M. Doyle et al.   EUROPEAN RESPIRATORY JOURNAL

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Innate Cells and T Helper 2 Cell Immunity in Airway Inflammation

(2009) Nora A. Barrett et al.   IMMUNITY

Pathogenesis of Asthma

(2008) STEPHEN T. HOLGATE   CLINICAL AND EXPERIMENTAL ALLERGY

Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12

(2008) Muriel Hachet-Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling