Article
Rheumatology
Eun Jeong Won, Hui-Ju Kim, Yu Jeong Lee, Moon-Ju Kim, Hae-In Lee, Hyun Hee Jang, Seong Hoon Kim, Ji-Hyoun Kang, Ki-Jeong Park, Seung Cheol Shim, Sungsin Jo, Tae-Hwan Kim, Tae-Jong Kim
Summary: This study aims to examine the effectiveness of CCL20 inhibition in treating inflammation in AS. The results show that CCL20 affects the migration of Th17 cells and that the CCL20 inhibitor can reduce joint inflammation in AS patients. Therefore, targeting CCL20 inhibition could be a novel therapeutic approach for AS treatment.
Article
Neurosciences
Jiapei Huang, Lan Yi, Xiaoxiao Yang, Qi Zheng, Jun Zhong, Sen Ye, Xican Li, Hui Li, Dongfeng Chen, Caixia Li
Summary: The transplantation of NSCs combined with ethyl stearate can improve the motor behavioral performance of PD rats by promoting NSCs migration and differentiation into dopaminergic neurons through CCL5/CCR5 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Yang Li, Shukun Han, Baokang Wu, Chongli Zhong, Yu Shi, Chao Lv, Lei Fu, Yizhou Zhang, Qi Lang, Zhiyun Liang, Yang Yu, Yu Tian
Summary: CXCL11 expression is higher in tumor tissue and has associations with prognosis, immune cell infiltration, tumor mutation burden, and microsatellite instability. Further investigation into CXCL11 may improve cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Han Zhang, Yu-Ming Hu, Ying-Jie Wang, Yue Zhou, Zhen-Jie Zhu, Min-Hao Chen, Yong-Jun Wang, Hua Xu, You-Hua Wang
Summary: Spinal cord injury leads to excessive inflammation, with accumulation of leukocytes at the lesion site. This study investigated the regulatory mechanism of resident cells in the spinal cord for the production of chemokines. It was found that macrophage migration inhibitory factor activation and its interaction with CD74 receptor play a role in producing chemokine C-C motif chemokine ligand 2 from astrocytes. Inhibiting macrophage migration inhibitory factor resulted in reduced recruitment of microglia/macrophages and improved hindlimb locomotor function after spinal cord injury. These findings provide insights into the role of astrocyte-activated chemokines and the potential for targeting chemokine C-C motif chemokine ligand 2 in treating neuroinflammation following spinal cord injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shabnam Babazadeh, Seyed Mahdi Nassiri, Vahid Siavashi, Mohadeseh Sahlabadi, Mostafa Hajinasrollah, Mohamad Zamani-Ahmadmahmudi
Summary: The study reveals the impact of MSC-derived CXCL12 on macrophage phenotypic switching towards M2, influencing their function in tumorigenesis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Allergy
Zhe-Zheng Wang, Jia Song, Hai Wang, Jing-Xian Li, Qiao Xiao, Ze Yu, Zhi-Chao Wang, Jin-Xin Liu, Li Pan, Yin Yao, Cai-Ling Chen, Xiang Lu, Chaohong Liu, Peisong Gao, Zheng Liu
Summary: The study revealed that IL-17A induced stromal cell remodeling in NPs, promoting interactions between B cells and stromal cells through CXCL13 and LT alpha(1)beta(2), leading to the enlargement of eLTs.
Article
Dermatology
Kenta Nakamura, Atsuko Ashida, Yukiko Kiniwa, Ryuhei Okuyama
Summary: This study found that CCL5 and CXCL12 in blood may serve as biomarkers to predict the therapeutic effect of anti-PD-1 therapy in patients with advanced malignant melanoma. Patients with lower levels of CCL5 and CXCL12 had more TILs and better disease-specific survival rates, indicating these chemokines could be useful predictors for treatment outcomes.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeonhee Lee, Jangwook Lee, Minkyoung Park, Areum Seo, Kyu Hyeon Kim, Seonmi Kim, Minjung Kang, Eunjeong Kang, Kyung Don Yoo, Sunhwa Lee, Dong Ki Kim, Kook-Hwan Oh, Yon Su Kim, Kwon Wook Joo, Seung Hee Yang
Summary: We investigated the levels of chemokine CCL8 in PD effluent and serum, as well as its tissue expression, and found an association with peritoneal fibrosis. We also found that CCL8 levels significantly increased with the duration of PD and were correlated with peritoneal transport parameters. In a mouse model, CCL8 blockade improved peritoneal inflammation and fibrosis.
Article
Biochemistry & Molecular Biology
Bei Song, Dongrui Chen, Zixiong Liu, Yuwen Cheng, Zebei Zhang, Weiqing Han, Ruiyan Zhang, Yanchun Gong
Summary: Recent studies have highlighted the role of vascular adventitia inflammation and immune response in hypertension. This study found that SDF-1 exerted opposing effects through CXCR4 and CXCR7 in AngII-induced vascular adventitial remodeling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Yingting Wu, Feilong Zhu, Wenqin Sun, Weiwei Shen, Qin Zhang, Huifen Chen
Summary: Endometriosis is a common gynecological disorder and its pathogenesis is still not fully understood. This study found that CCL28 overexpression in endometrial tissues is associated with the progression of endometriosis. Knocking down CCL28 suppresses cell proliferation and invasion, and this is mediated through the ERK signaling pathway and the regulation of MMP2, MMP9, and ITGB1 expression.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Oncology
Sven H. Loosen, Tom F. Ulmer, Simon Labuhn, Jan Bednarsch, Sven A. Lang, Patrick H. Alizai, Anne T. Schneider, Mihael Vucur, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Summary: This study identified circulating levels of CXCL13 as a previously unrecognized marker for predicting outcomes following the resection of BTC, highlighting the potential role of the CXC chemokine family in BTC pathogenesis.
Article
Biotechnology & Applied Microbiology
Longfei Deng, Jie Ren, Benqin Li, Yinggang Wang, Nianfen Jiang, Yi Wang, Hongjuan Cui
Summary: CCL2 is highly expressed in GBM and is associated with prognosis and immunotherapy response. It can serve as an independent prognostic factor for GBM patients and participate in the regulation of chemokine signaling pathway and inflammatory response.
Article
Oncology
Linping Gu, Yaxian Yao, Zhiwei Chen
Summary: The study explored the interaction among CXCL1/2/8 expressions in NSCLC patients. It revealed that high expression of CXCL1 was associated with worse disease-free survival and overall survival, while high expression of CXCL2 was also linked to poorer survival outcomes. High expression of CXCL1 was identified as an independent factor predicting shorter survival time.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Plant Sciences
Chueh-Tan Chen, Chian-Feng Chen, Tung-Yi Lin, Wei-Jyun Hua, Kate Hua, Ching-Yao Tsai, Chung-Hua Hsu
Summary: The study aimed to investigate the anti-mobility activity of the Chinese medical decoction Kuan-Sin-Yin (KSY) on hepatocellular carcinoma (HCC) cells and elucidate its molecular mechanism. The results showed that KSY inhibited the migration and invasion of HCC cells and induced changes in cell morphology. KSY regulated gene networks related to cell migration, invasion, and movement.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Mengmeng Li, Ying Xu, Kexue Pu, Jie Fan, Zheng Cheng, Hao Chen, Li Zhou
Summary: This study revealed a significant association between CXCL10 gene polymorphisms and the risk of chronic HBV infection in Chinese Han population. The A allele of the rs4508917 in CXCL10 was identified as a risk factor for persistent HBV infection, affecting the response to nucleos(t)ide analogues treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Infectious Diseases
Luis Horacio Gutierrez-Gonzalez, Esmeralda Juarez, Claudia Carranza, Laura E. Carreto-Binaghi, Alejandro Alejandre, Carlos Cabello-Gutierrrez, Yolanda Gonzalez
Summary: Diagnosing tuberculosis in children is challenging due to the limitations of traditional microbiological techniques. New methods based on immune response may be influenced by various factors. Personalized diagnosis could improve treatment outcomes by evaluating specific molecules produced by the host immune response.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Allergy
Martha Beatriz Morales-Amparano, Jose Angel Huerta-Ocampo, Guillermo Pastor-Palacios, Luis M. Teran
Summary: Enolase is an important cytosolic enzyme that is highly conserved among different taxonomical groups and participates in various processes. It has been widely recognized as an allergen, especially in molds and yeasts. Studies have shown that enolase plays a significant role in allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Fernando Ramirez-Jimenez, Andrea Vazquez-Corona, Paulina Sanchez-de la Vega Reynoso, Gandhi F. Pavon-Romero, Marco Alejandro Jimenez-Chobillon, Armando Roberto Castorena-Maldonado, Luis M. Teran
Summary: The study investigated the impact of leukotriene receptor antagonist (LTRA), montelukast, on lysine-acetylsalicylate (L-ASA) nasal challenge in patients with Aspirin-exacerbated respiratory disease (AERD). Results showed that AERD patients without LTRA exhibited a greater positive response to the L-ASA challenge compared to those taking LTRA, suggesting the discontinuation of LTRA treatment before the challenge for optimal diagnostic accuracy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Multidisciplinary Sciences
Tania Angeles-Floriano, Guadalupe Rivera-Torruco, Paulina Garcia-Maldonado, Esmeralda Juarez, Yolanda Gonzalez, Israel Parra-Ortega, Armando Vilchis-Ordonez, Briceida Lopez-Martinez, Lourdes Arriaga-Pizano, Dario Orozco-Ruiz, Jose Refugio Torres-Nava, Paula Licona-Limon, Francisco Lopez-Sosa, Alheli Bremer, Lourdes Alvarez-Arellano, Ricardo Valle-Rios
Summary: This study discovered a distinctive cluster with high levels of sGRP78, CD10, CD19, and CXCR4 in bone marrow samples from high-risk pediatric leukemia patients. Additionally, testing the presence of sGRP78 and CXCR4 may help achieve a better categorization of high and standard-risk pediatric leukemia.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Gandhi F. Pavon-Romero, Maria Itzel Parra-Vargas, Fernando Ramirez-Jimenez, Esmeralda Melgoza-Ruiz, Nancy H. Serrano-Perez, Luis M. Teran
Summary: Allergen immunotherapy (AIT) is an effective treatment for allergic rhinitis, preventing progression to asthma and reducing medication use. AIT works by inducing immunological tolerance and increasing specific levels and cell counts. Recent advancements in AIT research have focused on modifying allergens to improve treatment outcomes and minimize adverse reactions.
Article
Biochemistry & Molecular Biology
Maria Teresa Herrera, Esmeralda Juarez, Silvia Guzman-Beltran, Martha Torres, Victor Adrian Luna-Morales, Leonardo Daniel Villalana-Alvarez, Yolanda Gonzalez
Summary: Vitamin D deficiency in patients with Type 2 diabetes makes them more susceptible to developing tuberculosis. This study found that high concentrations of the inactive form of vitamin D can restore the ability of infected macrophages to express the antimicrobial peptide LL37, regardless of glucose concentrations. This supports the idea that vitamin D administration in patients with Type 2 diabetes could benefit tuberculosis control and prevention.
Article
Biochemistry & Molecular Biology
Itzia S. Gomez-Alonso, Sergio Martinez-Garcia, Gabriel Betanzos-Cabrera, Esmeralda Juarez, Maria C. Sarabia-Leon, Maria Teresa Herrera, Fernando Gomez-Chavez, Luvia Sanchez-Torres, Sandra Rodriguez-Martinez, Mario E. Cancino-Diaz, Jorge Cancino, Juan C. Cancino-Diaz
Summary: Protease-3 released by neutrophils in the presence of commensal non-biofilm-forming S. epidermidis plays a key role in promoting biofilm formation by facilitating cell aggregation through the release of bacterial DNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Juan Carlos Vizuet-de-Rueda, Josaphat Miguel Montero-Vargas, Miguel Angel Galvan-Morales, Raul Porras-Gutierrez-de-Velasco, Luis M. Teran
Summary: Respiratory allergies have a significant impact on human health worldwide. The study of these allergies requires new technologies, such as proteomics, which can enable early and accurate diagnosis and treatment. Proteomics has been applied to identify and analyze proteins using mass spectrometry, leading to advancements in diagnosing and treating respiratory allergic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Guadalupe Rivera-Torruco, Carolina A. Martinez-Mendiola, Tania Angeles-Floriano, Gustavo Alberto Jaimes-Ortega, Jose Luis Maravillas-Montero, Rodolfo Garcia-Contreras, Yolanda Gonzalez, Esmeralda Juarez, Porfirio Nava, Vianney Ortiz-Navarrete, Oscar Medina-Contreras, Paula Licona-Limon, Ricardo Valle-Rios
Summary: The process of blood cell generation and the role of lung as a significant source of hematopoietic progenitors have been investigated. A study identified ISM1 as a novel biomarker associated with progenitor-like cells in the lung. ISM1(+) cells were shown to be enriched in short-term hematopoietic stem cells and were affected in a mouse model of bacterial infection. These findings suggest a potential link between ISM1-producing cells and dangerous inflammatory responses.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Claudia Carranza, Laura Elena Carreto-Binaghi, Silvia Guzman-Beltran, Marcela Munoz-Torrico, Martha Torres, Yolanda Gonzalez, Esmeralda Juarez
Summary: There is a significant sex bias in the severity, prevalence, and pathogenesis of tuberculosis, with men having higher rates. Inflammatory markers show differences between men and women, with men showing higher levels of IL6, IL8, and TNF alpha. RvD1 plays a vital role in resolving inflammation in women with tuberculosis.
Review
Biochemistry & Molecular Biology
Ana Ruth Cadena-Suarez, Hilda Arely Hernandez-Hernandez, Noe Alvarado-Vasquez, Claudia Rangel-Escareno, Bettina Sommer, Maria Cristina Negrete-Garcia
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease with high mortality and unclear etiology. miRNAs may play a role in the development of IPF by regulating signaling pathways involved in the disease. Understanding the molecular mechanisms associated with miRNAs and IPF could potentially lead to new therapeutic targets for this severe lung disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria Cristina Negrete-Garcia, Javier de Jesus Ramos-Abundis, Noe Alvarado-Vasquez, Eduardo Montes-Martinez, Martha Montano, Carlos Ramos, Bettina Sommer
Summary: Communication between cells is mediated by extracellular vesicles, especially exosomes that contain mRNA and miRNA. Exosomal miRNAs have been studied for their potential as biomarkers for prognosis and diagnosis of various pathologies. However, their role in idiopathic pulmonary fibrosis (IPF), a chronic lung disease with no cure, is not well understood. This review focuses on the role of exosomal miRNAs in the onset and progression of IPF and discusses their potential as therapeutic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Martha Patricia Sierra-Vargas, Josaphat Miguel Montero-Vargas, Yazmin Debray-Garcia, Juan Carlos Vizuet-de-Rueda, Alejandra Loaeza-Roman, Luis M. Teran
Summary: Redox regulation plays a crucial role in controlling metabolism, with reactive oxygen and nitrogen species participating in various physiological reactions. Air pollution, particularly ambient particulate matter, containing transition metals and organic compounds, can induce inflammation, gene expression modulation, and activation of transcription factors, which contribute to the development of chronic respiratory diseases. This article provides an overview of the interaction between air pollution and redox regulation in the human body and its association with chronic respiratory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Laura E. Carreto-Binaghi, Maria Teresa Herrera, Silvia Guzman-Beltran, Esmeralda Juarez, Carmen Sarabia, Manuel G. Salgado-Cantu, Daniel Juarez-Carmona, Cristobal Guadarrama-Perez, Yolanda Gonzalez
Summary: At admission, COVID-19 patients had lower IL-8 secretion through TLR2, TLR4, and TLR7/8 receptors compared to healthy controls. After 14 days of hospitalization, there were significantly higher responses in IL-8, TNF-alpha, and IFN-gamma secretion through TLR2, TLR4, TLR7/8, TLR9, NOD1, NOD2, and IFN-gamma receptors. These findings suggest a possible role of these receptors in immunosuppression following hyperinflammation in COVID-19.
Review
Chemistry, Medicinal
Fernando Ramirez-Jimenez, Gandhi Fernando Pavon-Romero, Juancarlos Manuel Velasquez-Rodriguez, Mariana Itzel Lopez-Garza, Jose Fernando Lazarini-Ruiz, Katia Vanessa Gutierrez-Quiroz, Luis M. Teran
Summary: The discovery of the mechanism underlying allergic disease, mouse models of asthma, and bronchoscopy studies provided initial insights into the role of Th2-type cytokines. Monoclonal antibody therapies targeting these cytokines have been approved and shown to be effective alternatives to corticosteroids in severe asthma management. These targeted therapies have also been used in other diseases with type 2 inflammation, but the targeting of chemokines has not been successful.