Eosinophils Target Therapy for Severe Asthma: Critical Points

Eosinophilic and Noneosinophilic Asthma

(2018) Tara F. Carr et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab

(2018) Manali Mukherjee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sputum autoantibodies in patients with severe eosinophilic asthma

(2018) Manali Mukherjee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biologic Therapy and Novel Molecular Targets of Severe Asthma

(2017) Amber N. Pepper et al.   Journal of Allergy and Clinical Immunology-In Practice

Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels

(2016) Leif Bjermer et al.   CHEST

Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma

(2016) R. Sehmi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Treatable traits: toward precision medicine of chronic airway diseases

(2016) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Efficacy and Safety of Benralizumab, a Monoclonal Antibody against IL-5Rα, in Uncontrolled Eosinophilic Asthma

(2016) MirHojjat Khorasanizadeh et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

(2016) Steven G. Smith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical and inflammatory features of asthma with dissociation between fractional exhaled nitric oxide and eosinophils in induced sputum

(2016) Astrid Crespo et al.   JOURNAL OF ASTHMA

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

(2016) J Mark FitzGerald et al.   LANCET

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies

(2016) Hector G Ortega et al.   Lancet Respiratory Medicine

Improving the diagnosis of eosinophilic asthma

(2016) Hanneke Coumou et al.   Expert Review of Respiratory Medicine

Targeting the interleukin pathway in the treatment of asthma

(2015) Kian Fan Chung   LANCET

Blood or sputum eosinophils to guide asthma therapy?

(2015) Manali Mukherjee et al.   Lancet Respiratory Medicine

Biologics in Asthma—The Next Step Toward Personalized Treatment

(2015) Jared Darveaux et al.   Journal of Allergy and Clinical Immunology-In Practice

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12-month follow-up analysis

(2014) Pranabashis Haldar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti–Interleukin-5 Monoclonal Antibody to Treat Severe Eosinophilic Asthma

(2014) Parameswaran Nair   NEW ENGLAND JOURNAL OF MEDICINE

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current evidence and future research needs for FeNO measurement in respiratory diseases

(2014) Leif Bjermer et al.   RESPIRATORY MEDICINE

Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia

(2013) P. Nair et al.   ALLERGY

Primary lysis of eosinophils in severe desquamative asthma

(2013) C. Persson   CLINICAL AND EXPERIMENTAL ALLERGY

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects

(2013) William Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications

(2011) Raed A. Dweik et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma

(2010) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE