Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice

(2020) Christine Klaus et al.   NEUROBIOLOGY OF AGING

Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin α5β1 interaction and Akt signaling pathway

(2020) Xiaoman Zhou et al.   Cell Communication and Signaling

The role of the endothelial glycocalyx in advanced age and cardiovascular disease

(2019) Daniel R Machin et al.   CURRENT OPINION IN PHARMACOLOGY

Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases

(2019) Zoltan Ungvari et al.   GeroScience

Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension

(2019) Jun Peng et al.   CIRCULATION

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

(2018) Elizabeth J. White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

(2018) Julián Albarrán-Juárez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sialic acid deficiency is associated with oxidative stress leading to muscle atrophy and weakness in GNE myopathy

(2017) Anna Cho et al.   HUMAN MOLECULAR GENETICS

Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function

(2017) Kai B. Betteridge et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice

(2016) Shoudong Guo et al.   ATHEROSCLEROSIS

The glycocalyx and its significance in human medicine

(2016) J. M. Tarbell et al.   JOURNAL OF INTERNAL MEDICINE

The role of HYAL2 in LSS-induced glycocalyx impairment and the PKA-mediated decrease in eNOS–Ser-633 phosphorylation and nitric oxide production

(2016) Xiangquan Kong et al.   MOLECULAR BIOLOGY OF THE CELL

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases

(2015) Bernhard F. Becker et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 as an Endothelial Mechanosensitive Transcription Factor

(2015) Shane R. McSweeney et al.   HYPERTENSION

Regulation of an Inflammatory Disease

(2014) Mukesh K. Jain et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

(2014) Eno E. Ebong et al.   Integrative Biology

Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis

(2014) Jessilyn Dunn et al.   JOURNAL OF CLINICAL INVESTIGATION

Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro

(2013) Ke Bai et al.   Biomechanics and Modeling in Mechanobiology

Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation

(2013) Kristina M. Giantsos-Adams et al.   Cellular and Molecular Bioengineering

Roles of the nucleotide sugar transporters (SLC35 family) in health and disease

(2013) Zhiwei Song   MOLECULAR ASPECTS OF MEDICINE

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

(2012) Andrew Koo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mammalian sialidases: Physiological and pathological roles in cellular functions

(2012) T. Miyagi et al.   GLYCOBIOLOGY

NEU1 and NEU3 Sialidase Activity Expressed in Human Lung Microvascular Endothelia

(2012) Alan S. Cross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation

(2012) Miso Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice

(2012) Guangjin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice

(2012) Abraham Yang et al.   JOURNAL OF LIPID RESEARCH

Loss of the Endothelial Glycocalyx Links Albuminuria and Vascular Dysfunction

(2012) A. H. J. Salmon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Endothelial Glycocalyx Structure in the Intact Carotid Artery: A Two-Photon Laser Scanning Microscopy Study

(2011) Sietze Reitsma et al.   JOURNAL OF VASCULAR RESEARCH

Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation

(2010) Wakako Takabe et al.   ANTIOXIDANTS & REDOX SIGNALING

Oscillatory Shear Stress Induces Mitochondrial Superoxide Production: Implication of NADPH Oxidase and c-Jun NH2-Terminal Kinase Signaling

(2010) Wakako Takabe et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

(2010) Mohammad Nassimizadeh et al.   Diabetes & Vascular Disease Research

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

(2009) Schammim Ray Amith et al.   CELLULAR SIGNALLING

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633

(2009) Zhen Chen et al.   CIRCULATION RESEARCH

The Glycocalyx of the Human Umbilical Vein Endothelial Cell

(2009) Daniel Chappell et al.   CIRCULATION RESEARCH

Role of glycocalyx in flow-induced production of nitric oxide and reactive oxygen species

(2009) Robert Kumagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model

(2009) Wei Meng et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis

(2009) Sebastian Grundmann et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondria-Derived Reactive Oxygen Species Mediate Heme Oxygenase-1 Expression in Sheared Endothelial Cells

(2009) Z. Han et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

(2008) Joost O. Fledderus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH