Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells

CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes

(2020) Maopei Chen et al.   Science Advances

Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction

(2020) Devika P. Bagchi et al.   Molecular Metabolism

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

(2019) Gisela Geoghegan et al.   Molecular Metabolism

Extracellular vesicles: a new communication paradigm?

(2019) Graça Raposo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macrophages as a Source and Recipient of Wnt Signals

(2019) Elizabeth S. Malsin et al.   Frontiers in Immunology

SnapShot: Niche Determines Adipocyte Character I

(2018) Devika P. Bagchi et al.   Cell Metabolism

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

(2018) Albert G. Linden et al.   JOURNAL OF LIPID RESEARCH

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Properties and functions of adipose tissue macrophages in obesity

(2018) Lucia Russo et al.   IMMUNOLOGY

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

LKB1 signaling is activated in CTNNB1 -mutated HCC and positively regulates β-catenin-dependent CTNNB1 -mutated HCC

(2018) Sara Charawi et al.   JOURNAL OF PATHOLOGY

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis

(2017) Justin E. Lengfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Micro-Managing Fat: Exosomes as a New Messenger

(2017) Xiao-Wei Chen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer

(2016) Ikrame Lazar et al.   CANCER RESEARCH

Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose Homeostasis

(2016) Tianru Jin   ENDOCRINE REVIEWS

CD68/macrosialin: not just a histochemical marker

(2016) Dimitry A Chistiakov et al.   LABORATORY INVESTIGATION

Association of a gain-of-function variant in LGR4 with central obesity

(2016) Yaoyu Zou et al.   Obesity

Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages

(2016) Yohei Sanada et al.   Scientific Reports

De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose

(2015) Francis W. B. Sanders et al.   BIOLOGICAL REVIEWS

LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

(2015) Nellie Y. Loh et al.   Cell Metabolism

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System HomeostasisCLINICAL PERSPECTIVE

(2015) Khiem A. Tran et al.   CIRCULATION

Inhibition of  -catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes

(2015) N. J. Palpant et al.   DEVELOPMENT

Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin

(2015) Naravat Poungvarin et al.   ENDOCRINOLOGY

The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/ -Catenin Signaling

(2015) E. Hammond et al.   JOURNAL OF NEUROSCIENCE

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

(2015) Erica L. Scheller et al.   Nature Communications

Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis

(2014) J C Ralston et al.   INTERNATIONAL JOURNAL OF OBESITY

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Deletion of Serum Amyloid A3 Improves High Fat High Sucrose Diet-Induced Adipose Tissue Inflammation and Hyperlipidemia in Female Mice

(2014) Laura J. den Hartigh et al.   PLoS One

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

(2013) Angélique Gougelet et al.   HEPATOLOGY

Rare NonconservativeLRP6Mutations Are Associated with Metabolic Syndrome

(2013) Rajvir Singh et al.   HUMAN MUTATION

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Developmental pathways in colon cancer

(2012) Fred E. Bertrand et al.   CELL CYCLE

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition

(2012) Hiroyuki Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation

(2011) Harini Sampath et al.   Annals of the New York Academy of Sciences

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

(2011) William P. Cawthorn et al.   BONE

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Adipose tissue stem cells meet preadipocyte commitment: going back to the future

(2011) William P. Cawthorn et al.   JOURNAL OF LIPID RESEARCH

Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells

(2011) A. G. Cristancho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3-L1 Adipocytes

(2010) Ghada A. Soliman et al.   LIPIDS

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

(2010) Iris M Heid et al.   NATURE GENETICS

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

(2010) Andreas Weise et al.   NUCLEIC ACIDS RESEARCH

Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia

(2009) Anne Saarinen et al.   CLINICAL ENDOCRINOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

(2009) Z.-b. Deng et al.   DIABETES

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

(2008) D. ten Berge et al.   DEVELOPMENT