Role of Sigma-1 Receptor in Calcium Modulation: Possible Involvement in Cancer

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes

(2020) Zhangsen Zhou et al.   SCIENCE

Ca2+ Fluxes and Cancer

(2020) Saverio Marchi et al.   MOLECULAR CELL

Sigma 1 Receptor is Overexpressed in Hepatocellular Adenoma: Involvement of ERα and HNF1α

(2020) Laure Villemain et al.   Cancers

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy

(2020) Ming Yang et al.   Frontiers in Cell and Developmental Biology

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

The Sigma-1 Receptor in Cellular Stress Signaling

(2019) Teruo Hayashi   Frontiers in Neuroscience

Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses

(2018) Amado Carreras-Sureda et al.   CELL CALCIUM

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays

(2018) Hideaki Yano et al.   NEUROPHARMACOLOGY

Sigma-1 receptor (σ1R) is downregulated in hepatic malignant tumors and regulates HepG2 cell proliferation, migration and apoptosis

(2018) Qingxia Xu et al.   ONCOLOGY REPORTS

The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses

(2018) Denis Martinvalet   Cell Death & Disease

Mitochondria-associated membranes (MAMs) and inflammation

(2018) Sonia Missiroli et al.   Cell Death & Disease

The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update

(2018) Jennifer Rieusset   Cell Death & Disease

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings

(2018) Giampaolo Morciano et al.   NEOPLASIA

A novel fluorescent reporter detects plastic remodeling of mitochondria–ER contact sites

(2017) Zhaoying Yang et al.   JOURNAL OF CELL SCIENCE

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis

(2017) M Gueguinou et al.   ONCOGENE

APEX2-enhanced electron microscopy distinguishes sigma-1 receptor localization in the nucleoplasmic reticulum

(2017) Timur A. Mavlyutov et al.   Oncotarget

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

(2017) Yi Liu et al.   Translational Neurodegeneration

Sigma1 receptors inhibit store-operated Ca 2+ entry by attenuating coupling of STIM1 to Orai1

(2016) Shyam Srivats et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling

(2016) Roberto Bravo-Sagua et al.   Scientific Reports

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

(2016) Aleix Sala-Vila et al.   Scientific Reports

Interplay Between Intracellular Ca2+ Oscillations and Ca2+-stimulated Mitochondrial Metabolism

(2016) Benjamin Wacquier et al.   Scientific Reports

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling

(2015) Joachim Krebs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potential applications for sigma receptor ligands in cancer diagnosis and therapy

(2015) Aren van Waarde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA2+-filling state

(2015) Dmitrij A. Lisak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness

(2015) D. Crottes et al.   CANCER RESEARCH

Solution NMR studies reveal the location of the second transmembrane domain of the human sigma-1 receptor

(2015) Jose Luis Ortega-Roldan et al.   FEBS LETTERS

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

(2015) Shang-Yi A. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer as a channelopathy: ion channels and pumps in tumor development and progression

(2015) Alisa Litan et al.   Frontiers in Cellular Neuroscience

Structural basis for a pH-sensitive calcium leak across membranes

(2014) Y. Chang et al.   SCIENCE

Sigma 1 Receptor plays a prominent role in IL-24-induced cancer-specific apoptosis

(2013) Winchie Do et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Photoaffinity Labeling of the Sigma-1 Receptor with N-[3-(4-Nitrophenyl)propyl]-N-dodecylamine: Evidence of Receptor Dimers

(2013) Uyen B. Chu et al.   BIOCHEMISTRY

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

(2013) Juan Pablo Muñoz et al.   EMBO JOURNAL

Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions

(2013) Jose Luis Ortega-Roldan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Animal PET with a  -Ligand, 11C-SA4503, Detects Spontaneous Pituitary Tumors in Aged Rats

(2013) N. K. Ramakrishnan et al.   JOURNAL OF NUCLEAR MEDICINE

In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM)

(2013) Chloe N. Poston et al.   Journal of Proteomics

Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases

(2013) Yasuo Miki et al.   NEUROPATHOLOGY

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer

(2013) Olivia Crociani et al.   Scientific Reports

Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression

(2012) Felix J. Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

The Lifetime of UDP-galactose:Ceramide Galactosyltransferase Is Controlled by a Distinct Endoplasmic Reticulum-associated Degradation (ERAD) Regulated by Sigma-1 Receptor Chaperones

(2012) Teruo Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na+Channel with 4-Fold Symmetry

(2012) Dilshan Balasuriya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Sigma1 Receptor and Its Positive Associations With Pathologic TNM Classification in Esophageal Squamous Cell Carcinoma

(2012) Qing-Xia Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress

(2011) Teruhiko Mitsuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Investigation of the role of sigma1-receptors in inositol 1,4,5-trisphosphate dependent calcium signaling in hepatocytes

(2011) A. Abou-lovergne et al.   CELL CALCIUM

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Quantitative Proteomic Analyses of Human Cytomegalovirus-Induced Restructuring of Endoplasmic Reticulum-Mitochondrial Contacts at Late Times of Infection

(2011) Aiping Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor

(2011) Erik Laurini et al.   ACS Medicinal Chemistry Letters

Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers

(2010) S. Pillozzi et al.   BLOOD

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy

(2010) Pravin Mishra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NaV1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H+ efflux in caveolae

(2010) L Brisson et al.   ONCOGENE

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation

(2008) Veerle Vanderheyden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of Sigma-1 Receptor C-terminal Segment in Inositol 1,4,5-Trisphosphate Receptor Activation

(2008) Zhiping Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY