Article
Oncology
Yu Ma, Jie Chen, Xi Yao, Zhenzhen Li, Wensheng Li, Hongtao Wang, Jianfei Zhu
Summary: This study found that perineural invasion is prevalent and highly heterogeneous in squamous cell carcinoma, and it is associated with tumor depth and lymph node status. Perineural invasion is an independent factor affecting disease-free survival and overall survival in ESCC.
Article
Oncology
M. Hart Squires, Nicole Gower, Jennifer H. Benbow, Erin E. Donahue, Casey E. Bohl, Roshan S. Prabhu, Joshua S. Hill, Jonathan C. Salo
Summary: For ESCC patients treated with ChemoRT, PET imaging was not able to accurately predict the occurrence of pathologic complete response. Among patients with metabolic complete response, disease persistence was still found in a significant percentage of cases.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Tao Liu, Mengxing Li, Wen Cheng, Qianqian Yao, Yibo Xue, Xiaowei Wang, Hai Jin
Summary: A novel nomogram model incorporating ctDNA features was developed to predict the prognosis of resectable ESCC patients. It was found that ctDNA variants and mutation frequency can be potential biomarkers for predicting prognosis. The nomogram model showed clear prognostic superiority over the traditional TNM staging system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuang Lu, Chenglong Wang, Yun Liu, Funing Chu, Zhengyan Jia, Hongkai Zhang, Zhaoqi Wang, Yanan Lu, Shuting Wang, Guang Yang, Jinrong Qu
Summary: MRI radiomics models can predict pathological response in patients with locally advanced esophageal squamous cell carcinoma who received neoadjuvant chemotherapy. The Delta-model showed the best predictive efficacy among the Pre/Post-models.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Yin Li, Fengkai Xu, Fanghua Chen, Yiwei Chen, Di Ge, Shu Zhang, Chunlai Lu
Summary: This study comprehensively characterized ESCC, developed a robust scoring tool for prognosis assessment, highlighted the importance of TNS1(high) fibroblasts in the tumor microenvironment, and identified potential clinical drugs for the treatment of ESCC.
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Lei Xu, Xiu-feng Wei, Can-jun Li, Zhao-yang Yang, Yong-kui Yu, Hao-miao Li, Hou-nai Xie, Ya-fan Yang, Wei-wei Jing, Zhen Wang, Xiao-zheng Kang, Rui-xiang Zhang, Jian-jun Qin, Li-yan Xue, Nan Bi, Xian-kai Chen, Yin Li
Summary: This study compares the treatment response and postoperative complications of neoadjuvant immunochemotherapy (NICT) with conventional neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced esophageal squamous cell carcinoma (ESCC). The study finds that NICT has comparable R0 resection rate and pathological complete response (pCR) rate to NCRT, without increased incidence of postoperative complications and mortality. Notably, NICT may bring a better treatment response in metastatic lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Article
Cell Biology
Weixiong Yang, Chang-Han Chen, Minghan Jia, Xiangbin Xing, Lu Gao, Hsin-Ting Tsai, Zhanfei Zhang, Zhenguo Liu, Bo Zeng, Sai-Ching Jim Yeung, Mong-Hong Lee, Chao Cheng
Summary: The study revealed significant differences in the microbiota composition between patients with ESCC and those with PN esophagus, with the former showing reduced microbial diversity and decreased abundances of specific taxa. Functional analysis indicated altered nitrate reductase and nitrite reductase functions in the microbiota of ESCC patients. These findings suggest that specific microbes and microbiota may influence the development of ESCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Jusi Wang, Tingyu Chen, Weifeng Tang, Mingqiang Kang, Shuchen Chen
Summary: The study found that the rs2227282 (C > G) and rs2243283 (C > G) loci in the IL4 gene play protective roles in the development of ESCC, reducing the risk for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qingfu Zhu, Liu Huang, Qinsi Yang, Zheng Ao, Rui Yang, Jonathan Krzesniak, Doudou Lou, Liang Hu, Xiaodan Dai, Feng Guo, Fei Liu
Summary: Metabolomic analysis of plasma exosomes in patients with ESCC revealed 196 metabolites, with a marker set of 3'-UMP, palmitoleic acid, palmitaldehyde, and isobutyl decanoate showing high accuracy in predicting ESCC recurrence. These exosome metabolome signatures, likely associated with cancer metabolism, could potentially serve as novel biomarkers for diagnosis and prognosis of ESCC.
Article
Immunology
Yalan Yang, Dao Xin, Huike Wang, Lulu Guan, Xiangrui Meng, Taiying Lu, Xiwen Bai, Feng Wang
Summary: This study aims to develop and validate a novel predictor index called SITI to predict pathological complete response in resectable locally advanced esophageal squamous cell carcinoma patients receiving neoadjuvant immunochemotherapy. The results showed that SITI is an independent predictor for pCR and the nomogram using systemic inflammation-tumor markers is a promising tool for effectively differentiating pCR in these patients.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Yasukazu Kanie, Akihiko Okamura, Suguru Maruyama, Kei Sakamoto, Daisuke Fujiwara, Jun Kanamori, Yu Imamura, Masayuki Watanabe
Summary: This study retrospectively analyzed 208 patients with recurrent ESCC after surgery and found that elevated serum SCC-Ag levels at recurrence were significantly associated with a reduced time to recurrence, multiple recurrences, and a poor prognosis after recurrence. Further research is needed to find alternative treatments for patients with high serum SCC-Ag levels at recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Huiwu Geng, Cheng Feng, Zhangran Sun, Xu Fan, Yiqing Xie, Jinghua Gu, Libin Fan, Gang Liu, Chao Li, Rick F. Thorne, Xu Dong Zhang, Xinying Li, Xiaoying Liu
Summary: CLIC1 expression is increased in esophageal squamous cell carcinoma (ESCC) and contributes to its progression by promoting cell proliferation through the mTOR signaling pathway.
TRANSLATIONAL ONCOLOGY
(2023)