Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis

(2019) Eduardo Balsa et al.   MOLECULAR CELL

ER-associated degradation in health and disease – from substrate to organism

(2019) Asmita Bhattacharya et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes

(2018) L. Montibeller et al.   CELL STRESS & CHAPERONES

Mechanistic insights into ER-associated protein degradation

(2018) Xudong Wu et al.   CURRENT OPINION IN CELL BIOLOGY

The endoplasmic reticulum-–resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B- cell development in mice

(2018) Yi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity

(2018) Geun Hyang Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

(2018) Gian-Luca McLelland et al.   eLife

ER–Mitochondria Microdomains in Cardiac Ischemia–Reperfusion Injury: A Fresh Perspective

(2018) Hao Zhou et al.   Frontiers in Physiology

Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models

(2018) Kyu-Sun Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Here, there, and everywhere: The importance of ER membrane contact sites

(2018) Haoxi Wu et al.   SCIENCE

HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination

(2018) Juncheng Wei et al.   EMBO JOURNAL

Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

(2018) Asmita Bhattacharya et al.   EMBO JOURNAL

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum

(2017) Wei-Ke Ji et al.   JOURNAL OF CELL BIOLOGY

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)

(2017) Jasmin Schulz et al.   JOURNAL OF CELL SCIENCE

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis

(2017) Guojun Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantifying receptor trafficking and colocalization with confocal microscopy

(2017) Jeremy A. Pike et al.   METHODS

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria

(2017) Janos Steffen et al.   MOLECULAR BIOLOGY OF THE CELL

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

(2017) Stefan Schoebel et al.   NATURE

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

(2017) Ling Qi et al.   TRENDS IN CELL BIOLOGY

Loss-of-function mutations in theSIGMAR1gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+signalling

(2016) Elisa Gregianin et al.   HUMAN MOLECULAR GENETICS

Epithelial Sel1L is required for the maintenance of intestinal homeostasis

(2016) Shengyi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Direct and essential function for Hrd3 in ER-associated degradation

(2016) Nidhi Vashistha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

(2016) Yewei Ji et al.   Cell Reports

Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration

(2015) Nathalie Bernard-Marissal et al.   BRAIN

Endoplasmic reticulum quality control in cancer: Friend or foe

(2015) Hana Kim et al.   SEMINARS IN CANCER BIOLOGY

SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy

(2015) Marta Mellai et al.   Oncotarget

The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism

(2014) Haibo Sha et al.   Cell Metabolism

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

(2014) Jakob D Wikstrom et al.   EMBO JOURNAL

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

(2014) Shengyi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

(2013) J. Prause et al.   HUMAN MOLECULAR GENETICS

MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2

(2013) Ayumu Sugiura et al.   MOLECULAR CELL

ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

(2013) Andrew Murley et al.   eLife

The ATP-P2X7 Signaling Axis Is Dispensable for Obesity-Associated Inflammasome Activation in Adipose Tissue

(2012) S. Sun et al.   DIABETES

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A SEL1L Mutation Links a Canine Progressive Early-Onset Cerebellar Ataxia to the Endoplasmic Reticulum–Associated Protein Degradation (ERAD) Machinery

(2012) Kaisa Kyöstilä et al.   PLoS Genetics

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Serial Section Scanning Electron Microscopy of Adult Brain Tissue Using Focused Ion Beam Milling

(2008) G. Knott et al.   JOURNAL OF NEUROSCIENCE