The Heart of the Alzheimer's: A Mindful View of Heart Disease

Activating transcription factor 6 reduces Aβ1–42 and restores memory in Alzheimer’s disease model mice

(2020) Yayun Du et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

The Pathology of Amyloidosis in Classification: A Review

(2020) Maria M. Picken   ACTA HAEMATOLOGICA

Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer's Disease: Role of the P2Y2 receptor and endoplasmic reticulum stress

(2020) Junyoung Hong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

(2020) Bo Pan et al.   CIRCULATION RESEARCH

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases

(2020) Wioletta Rozpędek-Kamińska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart

(2020) Adrian Arrieta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway

(2020) Hui Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Bis(ethylmaltolato)oxidovanadium (IV) mitigates neuronal apoptosis resulted from amyloid-beta induced endoplasmic reticulum stress through activating peroxisome proliferator-activated receptor γ

(2020) Zhijun He et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators

(2020) Ying Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

Priming the Proteasome to Protect against Proteotoxicity

(2020) Xuejun Wang et al.   TRENDS IN MOLECULAR MEDICINE

The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor

(2020) Hai-Lian Bi et al.   Science Advances

Proteotoxicity and Neurodegenerative Diseases

(2020) Clara Ruz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease

(2020) Heather Buchanan et al.   MOLECULAR NEUROBIOLOGY

Selective Inhibition of the Immunoproteasome β5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy

(2020) Xin Xie et al.   Frontiers in Pharmacology

Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis

(2020) Moydul Islam et al.   Frontiers in Physiology

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R

(2020) Wen Yan et al.   Frontiers in Physiology

Insights of heat shock protein 22 in the cardiac protection against ischemic oxidative stress

(2020) Wenqian Wu et al.   Redox Biology

Proteasome malfunction activates the PPP3/calcineurin-TFEB-SQSTM1/p62 pathway to induce macroautophagy in the heart

(2020) Huabo Su et al.   Autophagy

Impact of Mitophagy and Mitochondrial Unfolded Protein Response as New Adaptive Mechanisms Underlying Old Pathologies: Sarcopenia and Non-Alcoholic Fatty Liver Disease

(2020) Rodrigo Urbina-Varela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Getting to the Heart of Alzheimer Disease

(2019) Joshua M. Tublin et al.   CIRCULATION RESEARCH

ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

(2019) Erik A. Blackwood et al.   CIRCULATION RESEARCH

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

(2019) Sundararajan Venkatesh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

(2019) Erik A. Blackwood et al.   Nature Communications

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

(2019) Jordan J. S. VerPlank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

(2019) Ioannis Smyrnias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Proteostasis and Beyond: ATF6 in Ischemic Disease

(2019) Christopher C. Glembotski et al.   TRENDS IN MOLECULAR MEDICINE

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

(2019) Pinaki Misra et al.   BIOCHEMISTRY

Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia–Reperfusion Injury

(2019) Naila Rabbani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

(2019) Xu-Qiao Chen et al.   Frontiers in Neuroscience

Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

(2019) Jack M. Webster et al.   Frontiers in Pharmacology

Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death

(2019) Seisuke Mimori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Ubiquitin Proteasome System in Ischemic and Dilated Cardiomyopathy

(2019) Sabine Spänig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucose-regulated protein 78 is essential for cardiac myocyte survival

(2018) Xiaoding Wang et al.   CELL DEATH AND DIFFERENTIATION

Deubiquitinase Inhibitor Auranofin Attenuated Cardiac Hypertrophy by Blocking NF-κB Activation

(2018) Ming Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation

(2018) Zhe Sha et al.   JOURNAL OF CELL BIOLOGY

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice

(2018) Qing Shu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The different axes of the mammalian mitochondrial unfolded protein response

(2018) Christian Münch   BMC BIOLOGY

Patterns of desmin expression in idiopathic dilated cardiomyopathy are related to the desmin mRNA and ubiquitin expression

(2018) Agnieszka Pawlak et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload

(2018) Chen Chen et al.   Redox Biology

Sildenafil Improves Vascular and Metabolic Function in Patients with Alzheimer’s Disease

(2017) Min Sheng et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteasome dysfunction in cardiomyopathies

(2017) Jennifer E. Gilda et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Cardiac Disorders as Risk Factors for Alzheimer's Disease

(2017) Tânia Corrêa de Toledo Ferraz Alves et al.   JOURNAL OF ALZHEIMERS DISEASE

TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation

(2016) Nilofer Husain et al.   AGING CELL

Association of LIM Domain 7 Gene Polymorphisms and Plasma Levels of LIM Domain 7 with Dilated Cardiomyopathy in a Chinese Population

(2016) ChunMei Li et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy

(2016) Zuhair N. Al-Hassnan et al.   BMC Medical Genetics

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease

(2016) John S. Beck et al.   Current Alzheimer Research

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease

(2016) Luca Troncone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

AL (Light-Chain) Cardiac Amyloidosis

(2016) Rodney H. Falk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy

(2015) Estibaliz Castillero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Proteotoxicity and Cardiac Dysfunction

(2015) P. M. McLendon et al.   CIRCULATION RESEARCH

Cofilin-2 Phosphorylation and Sequestration in Myocardial Aggregates

(2015) Khaushik Subramanian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

Native metastable prefibrillar oligomers are the most neurotoxic species among amyloid aggregates

(2014) Marco Diociaiuti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

(2014) Zhao V. Wang et al.   CELL

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity

(2014) J. Guan et al.   EMBO Molecular Medicine

Endoplasmic Reticulum Stress Sensor Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload–Induced Heart Failure and Lung Remodeling

(2014) Xiaoyu Liu et al.   HYPERTENSION

Heart failure and Alzheimer′s disease

(2014) P. Cermakova et al.   JOURNAL OF INTERNAL MEDICINE

Emerging novel concept of chaperone therapies for protein misfolding diseases

(2014) Yoshiyuki SUZUKI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Protein post-translational modifications and misfolding: New concepts in heart failure

(2014) Federica del Monte et al.   Proteomics Clinical Applications

Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice

(2013) Melinda Erzsébet Tóth et al.   CELL STRESS & CHAPERONES

Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins

(2013) Mark J. Ranek et al.   CIRCULATION

Role of the Ubiquitin Proteasome System in the Heart

(2013) Julia Pagan et al.   CIRCULATION RESEARCH

Posttranslational Modification and Quality Control

(2013) Xuejun Wang et al.   CIRCULATION RESEARCH

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Cytotoxicity of Intracellular A 42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

(2013) A. Demuro et al.   JOURNAL OF NEUROSCIENCE

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Polyubiquitination of the neurotrophin receptor p75 directs neuronal cell survival

(2012) Thangiah Geetha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The chemical chaperone 4-phenylbutyric acid attenuates pressure-overload cardiac hypertrophy by alleviating endoplasmic reticulum stress

(2012) Chang Sik Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease

(2012) J.-T. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Calpain 2 Activated through N-Methyl-D-Aspartic Acid Receptor Signaling Cleaves CPEB3 and Abrogates CPEB3-Repressed Translation in Neurons

(2012) C.-F. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Roles for the Sarco-/Endoplasmic Reticulum in Cardiac Myocyte Contraction, Protein Synthesis, and Protein Quality Control

(2012) Christopher C. Glembotski   PHYSIOLOGY

Endoplasmic Reticulum Stress Caused by Left Ventricular Hypertrophy in Rats: Effects of Telmisartan

(2011) Hong-Shan Guan et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Autophagy and p62 in Cardiac Proteinopathy

(2011) Qingwen Zheng et al.   CIRCULATION RESEARCH

The role of the ubiquitin proteasome system in Alzheimer's disease

(2011) Beat M Riederer et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

(2011) Jie Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism

(2011) J. Ojha et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperone-assisted protein folding: the path to discovery from a personal perspective

(2011) F Ulrich Hartl   NATURE MEDICINE

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

Ubiquitin Proteasome Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies

(2010) Jaime M. Predmore et al.   CIRCULATION

Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy

(2010) Davide Gianni et al.   CIRCULATION

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Clinical and genetic issues in dilated cardiomyopathy: A review for genetics professionals

(2010) Ray E Hershberger et al.   GENETICS IN MEDICINE

Modulation of Endoplasmic Reticulum Ca2+Store Filling by Cyclic ADP-ribose Promotes Inositol Trisphosphate (IP3)-evoked Ca2+Signals

(2010) Michiko Yamasaki-Mann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62, an autophagy hero or culprit?

(2010) Tor Erik Rusten et al.   NATURE CELL BIOLOGY

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38  MAPK pathway

(2010) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy

(2010) Klaus Stark et al.   PLoS Genetics

ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice

(2009) Qinghang Liu et al.   CIRCULATION RESEARCH

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Structural implications of mitochondrial dynamics

(2008) Jürgen Bereiter-Hahn et al.   Biotechnology Journal

Build it up-Tear it down: protein quality control in the cardiac sarcomere

(2008) M. S. Willis et al.   CARDIOVASCULAR RESEARCH

Protein quality control and degradation in cardiomyocytes

(2008) Xuejun Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of the unfolded protein response in the heart

(2007) Christopher C. Glembotski   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY