Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart

Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α

(2020) Winston T. Stauffer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

(2019) Erik A. Blackwood et al.   CIRCULATION RESEARCH

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

(2019) Erik A. Blackwood et al.   Nature Communications

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

(2019) Yahui Yan et al.   Nature Communications

GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)

(2019) Guangyu Zhang et al.   HYPERTENSION

Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt ActivationNovelty and Significance

(2018) Xukun Bi et al.   CIRCULATION RESEARCH

How Are Proteins Reduced in the Endoplasmic Reticulum?

(2018) Lars Ellgaard et al.   TRENDS IN BIOCHEMICAL SCIENCES

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms

(2018) Arvin B. Tam et al.   DEVELOPMENTAL CELL

Responses to reductive stress in the cardiovascular system

(2017) Diane E. Handy et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation

(2017) Steffen Preissler et al.   eLife

ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the HeartNovelty and Significance

(2016) Jung-Kang Jin et al.   CIRCULATION RESEARCH

Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control

(2016) Julia Behnke et al.   MOLECULAR CELL

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac MyocytesNovelty and Significance

(2015) Shirin Doroudgar et al.   CIRCULATION RESEARCH

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

(2015) Steffen Preissler et al.   eLife

Proteomic mapping of proteins released during necrosis and apoptosis from cultured neonatal cardiac myocytes

(2014) Kurt D. Marshall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sugarcoating ER Stress

(2014) Lisa Vincenz et al.   CELL

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

(2014) Zhao V. Wang et al.   CELL

Finding the Missing Link Between the Unfolded Protein Response and O-GlcNAcylation in the Heart

(2014) Christopher C. Glembotski   CIRCULATION RESEARCH

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic Injury

(2014) Qiujun Yu et al.   Journal of the American Heart Association

Orchestration of secretory protein folding by ER chaperones

(2013) Tali Gidalevitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Two phases of disulfide bond formation have differing requirements for oxygen

(2013) Marianne Koritzinsky et al.   JOURNAL OF CELL BIOLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calcium-mediated cell death during myocardial reperfusion

(2012) D. Garcia-Dorado et al.   CARDIOVASCULAR RESEARCH

Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome

(2012) Evangelia G. Kranias et al.   CIRCULATION RESEARCH

Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion

(2012) Christopher C. Glembotski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death

(2012) John A. Vekich et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Roles for the Sarco-/Endoplasmic Reticulum in Cardiac Myocyte Contraction, Protein Synthesis, and Protein Quality Control

(2012) Christopher C. Glembotski   PHYSIOLOGY

The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load

(2011) King-Tung Chin et al.   FASEB JOURNAL

Structural Basis of Carbohydrate Recognition by Calreticulin

(2010) Guennadi Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure

(2010) Christopher C. Glembotski   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Roles for Endoplasmic Reticulum–Associated Degradation and the Novel Endoplasmic Reticulum Stress Response Gene Derlin-3 in the Ischemic Heart

(2009) Peter J. Belmont et al.   CIRCULATION RESEARCH

Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response

(2009) Shirin Doroudgar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of Growth and Endoplasmic Reticulum Stress Signaling by Regulator of Calcineurin 1 (RCAN1), a Novel ATF6-inducible Gene

(2008) Peter J. Belmont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE