Article
Cell Biology
Shigang Qiao, Lei Hong, Yongming Zhu, Jun Zha, An Wang, Jia Qiu, Wei Li, Chen Wang, Jianzhong An, Huiling Zhang
Summary: Receptor-interacting protein kinase 1 and 3 play important roles in myocardial fibrosis and diabetic cardiomyopathy by activating the RIPK1/RIPK3 pathway and impairing the autophagic process.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Qin Huang, Liqun Tian, Yi Zhang, Zhen Qiu, Shaoqing Lei, Zhong-Yuan Xia
Summary: This study found that nobiletin, a flavonoid isolated from citrus peels, has a protective effect on myocardial ischemia-reperfusion (IR) injury in rats with type-2 diabetes. It may achieve this effect by inhibiting the expression of ferroptosis-related proteins.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Chuncha Bao, Siyi Zhu, Kangping Song, Chengqi He
Summary: This review explores the role and mechanism of glucose metabolism, specifically focusing on the involvement of hexokinase 2 (HK2), in the pathogenesis of osteoarthritis (OA). Studies have shown that aerobic glycolysis plays a crucial role in OA, and HK2 is considered a key regulator of glucose metabolism. The elevated expression of HK2 in OA synovial tissue suggests its potential therapeutic effect in managing OA.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Naila Rabbani, Mingzhan Xue, Paul J. Thornalley
Summary: The glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has been discovered to be a key factor in the development of insulin resistance and vascular complications in diabetes. This leads to HK2-linked glycolytic overload and unscheduled glycolysis, causing mitochondrial dysfunction and increased reactive oxygen species formation, among other metabolic consequences. The use of glyoxalase 1 inducer-trans-resveratrol and hesperetin in combination has shown promising results in reversing the effects of HK2-linked glycolytic overload and unscheduled glycolysis in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qin Huang, Hao Tian, Liqun Tian, Xiaoshuai Zhao, Lu Li, Yuxi Zhang, Zhen Qiu, Shaoqing Lei, Zhongyuan Xia
Summary: This study found that ferroptosis is involved in the susceptibility to myocardial ischemia-reperfusion injury during type-2 diabetes, and targeting Rev-erb alpha may alleviate myocardial IR injury by inhibiting ferroptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Masoumeh Asgari, Iraj Salehi, Kamal Ranjbar, Maryam Khosravi, Ebrahim Zarrinkalam
Summary: This study evaluated the effects of exercise training and Crataegus persica extract on myocardial ischemia-reperfusion-induced kidney injury in diabetic rats. The results showed that interval training and Crataegus persica treatment decreased renal damage, improved insulin sensitivity and renal function in these rats.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Parth M. Patel, Margaret R. Connolly, Taylor M. Coe, Anthony Calhoun, Franziska Pollok, James F. Markmann, Lars Burdorf, Agnes Azimzadeh, Joren C. Madsen, Richard N. Pierson
Summary: Recent advances in minimizing ischemia have shown promising results in reducing initial xenograft dysfunction in pig-to-non-human primate heart transplantation, indicating the significant role of ischemia reperfusion injury (IRI) in cardiac xenotransplantation. Understanding the molecular, cellular, and immune mechanisms of IRI and primary graft dysfunction in allotransplantation can help develop genetic modifications and technical strategies to minimize IRI and improve clinical xenotransplantation outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jiaojiao Wei, Lili Zhang, Kaicheng Wu, Jian Yu, Fengjuan Gao, Jingyi Cheng, Ting Zhang, Xujiao Zhou, Yuan Zong, Xiaojing Huang, Chunhui Jiang
Summary: This study found that both endogenous and exogenous cannabinoids can regulate the contraction and dilation of retinal capillaries, and this effect is related to changes in cell width.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Xiudi Zhou, Qiang Chen, Chunjing Guo, Yanguo Su, Huimin Guo, Min Cao, Zhongxin Liu, Dandan Zhang, Ningning Diao, Huaying Fan, Daquan Chen
Summary: A novel drug delivery system has been developed to precisely deliver drugs to pathological renal tissue for attenuating renal ischemia-reperfusion injury. The system exhibits responsive properties to reactive oxygen species, biocompatibility, and cell penetration. The intracellular concentration of hydrogen sulfide released by the system is threefold higher than that in the control group, and it demonstrates anti-inflammatory effects by blocking the NF-KB signaling pathway. This research provides a promising strategy for pharmaceutical treatment of renal ischemia-reperfusion injury.
Review
Cardiac & Cardiovascular Systems
Shuxian Chen, Yuanming Zou, Chunyu Song, Kexin Cao, Kexin Cai, Yanjiao Wu, Zhaobo Zhang, Danxi Geng, Wei Sun, Nanxiang Ouyang, Naijin Zhang, Zhao Li, Guozhe Sun, Yixiao Zhang, Yingxian Sun, Ying Zhang
Summary: Cardiovascular disease is a significant threat to human health, and the glycolytic pathway and its enzymes play important roles in its development.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Review
Medicine, Research & Experimental
Min Lu, Meng Jia, Qun Wang, Yurong Guo, Chunlin Li, Boxu Ren, Feng Qian, Jianping Wu
Summary: Cardiac tissue ischemia/hypoxia increases glycolysis and lactic acid accumulation in cardiomyocytes, leading to intracellular metabolic acidosis. Sodium bicarbonate cotransporters (NBCs) play a vital role in modulating intracellular pH and maintaining sodium ion concentrations in cardiomyocytes, with NBCe1 being actively involved in myocardial ischemia/reperfusion (I/R) injury. Further studies on NBCe1 activity regulation mechanisms could offer novel therapeutic targets for preventing I/R-induced cardiac diseases.
Article
Immunology
Dong Liu, Cuijie Zhang, Min Hu, Kangle Su
Summary: Scutellarein demonstrates renal protective effects against ischemic AKI, potentially through inhibition of COX-2, leading to alleviation of kidney damage, suppression of apoptosis and inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li Ma, Na Zhou, Huikang Tao, Hao Zhou, Ying Tan, Weidan Chen, Fan Cao, Xinxin Chen
Summary: This study investigated the impact of TMBIM6 and PS2 on mitochondrial homeostasis during acute reperfusion injury. It was found that myocardial post-ischemic reperfusion stress disrupted mitochondrial integrity, leading to cardiac dysfunction and cardiomyocyte death, which could be prevented by sufficient expression of TMBIM6. Furthermore, TMBIM6 directly bound to PS2 and promoted its post-transcriptional degradation, thereby reducing reperfusion-induced mitochondrial damage. These findings suggest that TMBIM6 and PS2 are promising therapeutic targets for the treatment of cardiac reperfusion damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Urology & Nephrology
Keisuke Sako, Kengo Furuichi, Shohei Makiishi, Yuta Yamamura, Toshiya Okumura, Hong Thu Le, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Fumio Niimura, Taiji Matsusaka, Shuichi Kaneko, Takashi Wada
Summary: Paired box 2 (Pax2) is an essential transcription factor for kidney development and is reactivated during recovery from kidney injury. This study reveals that Pax2 reactivation plays a role in the regulation of cell proliferation in proximal tubular epithelial cells (PTECs). Knockout of Pax2 leads to increased interstitial fibrosis, decreased cell proliferation, and increased apoptotic cells.
KIDNEY INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Wei Zhao, Jia Zhao, Xiuying Zhang, Ni Fan, Jianhui Rong
Summary: The study demonstrated that puerarin can reduce myocardial infarct size and LDH release in a mouse model of myocardial ischemia/reperfusion injury. Through promoting protein SUMOylation and activating the ER/ERK pathway, puerarin shows cardioprotective effects in alleviating myocardial injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Naila Rabbani, Paul J. Thornalley
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Biochemistry & Molecular Biology
Chung-Jung Chiu, Naila Rabbani, Sheldon Rowan, Min-Lee Chang, Sherilyn Sawyer, Frank B. Hu, Walter Willett, Paul J. Thornalley, Attia Anwar, Liliana Bar, Jae H. Kang, Allen Taylor
Article
Genetics & Heredity
Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J. Thornalley, Naila Rabbani
Article
Cell Biology
Florence Hariton, Mingzhan Xue, Naila Rabbani, Mark Fowler, Paul J. Thornalley
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Multidisciplinary Sciences
Zehra Irshad, Mingzhan Xue, Amal Ashour, James R. Larkin, Paul J. Thornalley, Naila Rabbani
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Jinit Masania, Gernot Faustmann, Attia Anwar, Hildegard Hafner-Giessauf, Nasir Rajpoot, Johanna Grabher, Kashif Rajpoot, Beate Tiran, Barbara Obermayer-Pietsch, Brigitte M. Winklhofer-Roob, Johannes M. Roob, Naila Rabbani, Paul J. Thornalley
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Review
Biochemistry & Molecular Biology
Naila Rabbani, Paul J. Thornalley
Article
Biochemistry & Molecular Biology
Sheldon Rowan, Shuhong Jiang, Min-Lee Chang, Jonathan Volkin, Christa Cassalman, Kelsey M. Smith, Matthew D. Streeter, David A. Spiegel, Carlos Moreira-Neto, Naila Rabbani, Paul J. Thornalley, Donald E. Smith, Nadia K. Waheed, Allen Taylor
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Naila Rabbani
Summary: This article introduces the utility of AGEomics biomarkers and provides evidence for their closer association with disease phenotypes compared to other metabolites and metabolomic approaches. It also discusses how to train and test algorithms using machine learning methods for accurate and sensitive clinical diagnostic and screening applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Naila Rabbani, Paul J. Thornalley
Summary: The abnormal accumulation of methylglyoxal has been linked to aging and disease. Glyoxalase 1 plays a major role in the metabolism of methylglyoxal. Small molecule inducers of Glyoxalase 1 have been developed to alleviate dicarbonyl stress and treat type 2 diabetes. Moreover, cell permeable Glyoxalase 1 inhibitor prodrugs show potential as a treatment for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Medicine, Research & Experimental
Naila Rabbani
Summary: The study found increased exposure of diabetic patients to methylglyoxal (MG), and the glyoxalase system plays an important role in the development of insulin resistance and vascular complications of diabetes. Other advances include the discovery of a new metabolic stress and therapeutic methods.
Article
Biochemistry & Molecular Biology
Naila Rabbani, Antonysunil Adaikalakoteswari, James R. R. Larkin, Sianna Panagiotopoulos, Richard J. J. MacIsaac, Dennis K. K. Yue, Gregory R. R. Fulcher, Matthew A. A. Roberts, Merlin A. Thomas, Elif Ekinci, Paul J. J. Thornalley
Summary: Accumulation of advanced glycation endproducts (AGEs) is associated with decline in renal function, particularly in diabetic patients. This study evaluated levels of AGEs in subjects with and without diabetes, with normal renal function and stages 2-4 chronic kidney disease (CKD), and identified a specific AGE, methylglyoxal-derived hydroimidazolone (MG-H1) free adduct, as the most responsive to CKD status and diabetes. The concentration of MG-H1 free adduct in serum was strongly related to CKD stage and increased in diabetes. This suggests that serum MG-H1 free adduct may serve as a potential AGE risk marker for diabetic and non-diabetic CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Amal Ashour, Mingzhan Xue, Maryam Al-Motawa, Paul J. Thornalley, Naila Rabbani
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Rheumatology
Catherine Legrand, Usman Ahmed, Attia Anwar, Kashif Rajpoot, Sabah Pasha, Cecile Lambert, Rose K. Davidson, Ian M. Clark, Paul J. Thornalley, Yves Henrotin, Naila Rabbani
ARTHRITIS RESEARCH & THERAPY
(2018)