β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology
Authors
Keywords
-
Journal
Journal of Neuroinflammation
Volume 17, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-09-21
DOI
10.1186/s12974-020-01948-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Inhibition of adenosine A1 receptors abolished the nutritional ketosis-evoked delay in the onset of isoflurane-induced anesthesia in Wistar Albino Glaxo Rijswijk rats
- (2020) Zsolt Kovács et al. BMC Anesthesiology
- Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
- (2019) Julia K Götzl et al. EMBO Molecular Medicine
- The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease
- (2019) Bhumsoo Kim et al. NEUROBIOLOGY OF DISEASE
- NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
- (2018) Clifford R. Jack et al. Alzheimers & Dementia
- ApoE facilitates the microglial response to amyloid plaque pathology
- (2018) Jason D. Ulrich et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
- (2018) Justyna Sosna et al. Molecular Neurodegeneration
- Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease
- (2018) Miho Ota et al. NEUROSCIENCE LETTERS
- Microglia in Alzheimer’s disease
- (2017) Heela Sarlus et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease
- (2017) Robert J. Pawlosky et al. JOURNAL OF NEUROCHEMISTRY
- The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia
- (2017) Vandana Deora et al. Journal of Neuroimmune Pharmacology
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
- (2017) Na Zhao et al. NEURON
- Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats
- (2017) Rennan de Oliveira Caminhotto et al. Nutrition & Metabolism
- Adenosine A1 Receptor Antagonism Abolished the Anti-seizure Effects of Exogenous Ketone Supplementation in Wistar Albino Glaxo Rijswijk Rats
- (2017) Zsolt Kovács et al. Frontiers in Molecular Neuroscience
- Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease
- (2016) Danielle S. Davies et al. BRAIN PATHOLOGY
- The “Big-Bang” for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia
- (2016) Amanda Sierra et al. GLIA
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective
- (2015) Matthew Baumgart et al. Alzheimers & Dementia
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- (2015) Yun-Hee Youm et al. NATURE MEDICINE
- γ-Hydroxybutyrate (Xyrem) ameliorates clinical symptoms and neuropathology in a mouse model of Alzheimer's disease
- (2015) Christian Klein et al. NEUROBIOLOGY OF AGING
- Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
- (2015) Carlo Condello et al. Nature Communications
- Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease
- (2014) Rona Baron et al. AGING CELL
- Brain metabolic dysfunction at the core of Alzheimer's disease
- (2014) Suzanne M. de la Monte et al. BIOCHEMICAL PHARMACOLOGY
- Microglial priming in neurodegenerative disease
- (2014) V. Hugh Perry et al. Nature Reviews Neurology
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
- (2012) Yoshihiro Kashiwaya et al. NEUROBIOLOGY OF AGING
- 2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease
- (2011) Jia Yao et al. PLoS One
- Dietary ketosis enhances memory in mild cognitive impairment
- (2010) Robert Krikorian et al. NEUROBIOLOGY OF AGING
- Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
- (2009) Clifford R Jack et al. LANCET NEUROLOGY
- The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
- (2009) Luigi Franchi et al. NATURE IMMUNOLOGY
- Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial
- (2009) Samuel T Henderson et al. Nutrition & Metabolism
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
- (2009) J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance
- (2008) T. Bolmont et al. JOURNAL OF NEUROSCIENCE
- Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-A Antibody Administration in PDAPP Mice
- (2008) J. Koenigsknecht-Talboo et al. JOURNAL OF NEUROSCIENCE
- The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus
- (2008) Eric C Westman et al. Nutrition & Metabolism
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started