Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

(2019) Shogo Sato et al.   Cell Metabolism

Analysis of hypoxanthine and lactic acid levels in vitreous humor for the estimation of post-mortem interval (PMI) using LC–MS/MS

(2019) Ahra Go et al.   FORENSIC SCIENCE INTERNATIONAL

α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway

(2018) Xingcai Cai et al.   FASEB JOURNAL

UPLC–Orbitrap–MS/MS combined with chemometrics establishes variations in chemical components in green tea from Yunnan and Hunan origins

(2018) Zhongquan Xin et al.   FOOD CHEMISTRY

Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway

(2018) Jingren Xu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3

(2017) Céline Aguer et al.   FASEB JOURNAL

Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice

(2017) Naresh C. Bal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Effect of High-Intensity Interval Training on Total, Abdominal and Visceral Fat Mass: A Meta-Analysis

(2017) Florie Maillard et al.   SPORTS MEDICINE

Heparin Increases Food Intake through AgRP Neurons

(2017) Canjun Zhu et al.   Cell Reports

Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

(2017) Yuwei Jiang et al.   eLife

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

(2017) Cristina Contreras et al.   Redox Biology

The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications

(2016) Dingfu Xiao et al.   AMINO ACIDS

ADAP-GC 3.0: Improved Peak Detection and Deconvolution of Co-eluting Metabolites from GC/TOF-MS Data for Metabolomics Studies

(2016) Yan Ni et al.   ANALYTICAL CHEMISTRY

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

(2016) Mamta Rai et al.   Annual Review of Physiology

Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use

(2016) Barbara Zdzisińska et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice

(2016) Ameh Omede et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alpha-Ketoglutarate: Physiological Functions and Applications

(2016) Nan Wu et al.   Biomolecules & Therapeutics

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Interleukin-6-mediated signaling in adrenal medullary chromaffin cells

(2016) Danielle E. Jenkins et al.   JOURNAL OF NEUROCHEMISTRY

Metabolic time-course response after resistance exercise: A metabolomics approach

(2016) Ricardo Berton et al.   JOURNAL OF SPORTS SCIENCES

Evidence for a critical role of the sympathetic nervous system in hypertension

(2016) Guido Grassi et al.   Journal of the American Society of Hypertension

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis

(2016) Johanna Abrigo et al.   Oxidative Medicine and Cellular Longevity

Quantification of fumarate and investigation of endogenous and exogenous fumarate stability in rat plasma by LC–MS/MS

(2016) Yao Shi et al.   Bioanalysis

Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways

(2016) Xingcai Cai et al.   Scientific Reports

Exercise regulation of adipose tissue

(2016) Kristin I. Stanford et al.   Adipocyte

Dietary supplementation with glutamate precursor α-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs

(2015) Lei Wang et al.   AMINO ACIDS

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

(2015) Svenia Schnyder et al.   BONE

Expression and localization of GPR91 and GPR99 in murine organs

(2015) Julia Diehl et al.   CELL AND TISSUE RESEARCH

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

The Physiological Basis and Nutritional Function of Alpha-ketoglutarate

(2015) Liuqin He et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Human Brown Adipose Tissue: What We Have Learned So Far

(2015) Matthias J. Betz et al.   DIABETES

BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice

(2015) Tae Woo Jung et al.   DIABETOLOGIA

Change in weight and body composition in obese subjects following a hypocaloric diet plus different training programs or physical activity recommendations

(2015) Pedro J. Benito et al.   JOURNAL OF APPLIED PHYSIOLOGY

Lipolysis and lipases in white adipose tissue – An update

(2015) Andressa Bolsoni-Lopes et al.   Archives of Endocrinology Metabolism

Up-Regulation of NaV1.7 Sodium Channels Expression by Tumor Necrosis Factor-α in Cultured Bovine Adrenal Chromaffin Cells and Rat Dorsal Root Ganglion Neurons

(2014) Ryuji Tamura et al.   ANESTHESIA AND ANALGESIA

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness

(2014) Kim M. Huffman et al.   DIABETOLOGIA

Neural innervation of white adipose tissue and the control of lipolysis

(2014) Timothy J. Bartness et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Lactate activates the somatotropic axis in rats

(2014) Rafael Barrera Salgueiro et al.   GROWTH HORMONE & IGF RESEARCH

Blood Ammonia and Lactate as Markers of Muscle Metabolites During Leg Press Exercise

(2014) Esteban M. Gorostiaga et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Thyroid Hormone Regulation of Metabolism

(2014) Rashmi Mullur et al.   PHYSIOLOGICAL REVIEWS

Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity

(2014) Nicole G. Barra et al.   PLoS One

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Overweight and Obesity in Children and Adolescents

(2014) Neslihan Koyuncuoğlu Güngör   Journal of Clinical Research in Pediatric Endocrinology

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Effects of eccentric exercise on branched-chain amino acid profiles in rat serum and skeletal muscle

(2013) Z. Qun et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism

(2013) Natsuko Tokonami et al.   JOURNAL OF CLINICAL INVESTIGATION

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

The origin and definition of brite versus white and classical brown adipocytes

(2013) Matthias Rosenwald et al.   Adipocyte

Physical activity in obesity and metabolic syndrome

(2012) Barbara Strasser   Annals of the New York Academy of Sciences

Biomarkers of peripheral muscle fatigue during exercise

(2012) Josef Finsterer   BMC MUSCULOSKELETAL DISORDERS

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse

(2012) Joseph E. Kerschner et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Independent component analysis in non-hypothesis driven metabolomics: Improvement of pattern discovery and simplification of biological data interpretation demonstrated with plasma samples of exercising humans

(2012) Xiang Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Immune-Neuroendocrine Integration at the Adrenal Gland: Cytokine Control of the Adrenomedullary Transcriptome

(2012) Stephen J. Bunn et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Metabolic master regulators: sharing information among multiple systems

(2012) Barbara E. Corkey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice

(2011) Zhidan Luo et al.   CELL RESEARCH

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Cytokine Interactions with Adrenal Medullary Chromaffin Cells

(2010) Shirley A. Douglas et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Alpha-Ketoglutarate and intestinal function

(2010) Yongqing Hou   Frontiers in Bioscience-Landmark

Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks

(2010) S Collins et al.   INTERNATIONAL JOURNAL OF OBESITY

1H NMR-Based Metabonomic Investigation of the Effect of Two Different Exercise Sessions on the Metabolic Fingerprint of Human Urine

(2010) Alexandros Pechlivanis et al.   JOURNAL OF PROTEOME RESEARCH

Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue

(2010) Rana I. Sharara-Chami et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolic Signatures of Exercise in Human Plasma

(2010) G. D. Lewis et al.   Science Translational Medicine

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1β: role of neuropeptide Y and nitric oxide

(2009) Joana Rosmaninho-Salgado et al.   JOURNAL OF NEUROCHEMISTRY

Serum Metabolite Profiling of Human Colorectal Cancer Using GC−TOFMS and UPLC−QTOFMS

(2009) Yunping Qiu et al.   JOURNAL OF PROTEOME RESEARCH

Transcriptome analysis by strand-specific sequencing of complementary DNA

(2009) Dmitri Parkhomchuk et al.   NUCLEIC ACIDS RESEARCH

Tumor Necrosis Factor (TNF)-α Persistently Activates Nuclear Factor-κB Signaling through the Type 2 TNF Receptor in Chromaffin Cells: Implications for Long-Term Regulation of Neuropeptide Gene Expression in Inflammation

(2008) Djida Ait-Ali et al.   ENDOCRINOLOGY

Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: Relevance to its antidepressant/anxiolytic-like profile

(2008) Y. Claustre et al.   NEUROSCIENCE

Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity

(2008) Johan W.E. Jocken et al.   PHYSIOLOGY & BEHAVIOR