Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

(2015) Andrea Palermo et al.   CLINICAL ENDOCRINOLOGY

The Effect of Exercise on Lipid Profiles and Inflammatory Markers in Lean Male Adolescents

(2015) Chun-Jui Huang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The myokine irisin increases cortical bone mass

(2015) Graziana Colaianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysis

(2015) Chun Zhang et al.   Journal of Diabetes

Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice

(2014) Yuwei Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

(2014) Milan K. Piya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise

(2014) Julia Brenmoehl et al.   International Journal of Biological Sciences

Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months

(2014) A. D. Anastasilakis et al.   OSTEOPOROSIS INTERNATIONAL

Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway: An Approach for Treating Bone Disease in Diabetes

(2014) Liming Yu et al.   STEM CELLS

Irisin Enhances Osteoblast DifferentiationIn Vitro

(2014) Graziana Colaianni et al.   International Journal of Endocrinology

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1

(2013) Daisuke Kajimura et al.   Cell Metabolism

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

Altered thermogenesis and impaired bone remodeling inMistymice

(2013) Katherine J Motyl et al.   JOURNAL OF BONE AND MINERAL RESEARCH

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes

(2013) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lower circulating irisin is associated with type 2 diabetes mellitus

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin-immunoreactivity in neural and non-neural cells of the rodent

(2013) S.L. Dun et al.   NEUROSCIENCE

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1?

(2012) Erin J. Stephenson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women

(2012) Miriam A. Bredella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown Adipose Tissue and Its Relationship to Bone Structure in Pediatric Patients

(2012) Skorn Ponrartana et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

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(2012) Show-Huie Chen   Journal of Medical and Biological Engineering

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women

(2012) P. Lee et al.   OSTEOPOROSIS INTERNATIONAL

Update on Wnt signaling in bone cell biology and bone disease

(2011) David G. Monroe et al.   GENE

Human Brown Adipose Tissue

(2010) Sven Enerbäck   Cell Metabolism

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function

(2008) Matthew P. Krause et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of bone remodeling by the central and peripheral nervous system

(2008) Florent Elefteriou   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Overexpression of Bone Sialoprotein Leads to an Uncoupling of Bone Formation and Bone Resorption in Mice

(2008) Paloma Valverde et al.   JOURNAL OF BONE AND MINERAL RESEARCH