Zebrafish models of acute leukemias: Current models and future directions

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Follistatin is a novel therapeutic target and biomarker in FLT 3/ ITD acute myeloid leukemia

(2020) Bai‐Liang He et al.   EMBO Molecular Medicine

A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia

(2020) Elena Arriazu et al.   Blood Cancer Journal

Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo

(2020) M. Wei et al.   Oncogenesis

Prognostic impact of CSF3R mutations in favorable risk childhood acute myeloid leukemia

(2020) Katherine Tarlock et al.   BLOOD

Yolk sac hematopoiesis: does it contribute to the adult hematopoietic system?

(2020) Valerie Wittamer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic biomarkers of drug resistance: A compass of prognosis and targeted therapy in acute myeloid leukemia

(2020) Luyao Long et al.   DRUG RESISTANCE UPDATES

Towards a New Understanding of Decision-Making by Hematopoietic Stem Cells

(2020) Geoffrey Brown   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathogenesis of pediatric B‑cell acute lymphoblastic leukemia: Molecular pathways and disease treatments (Review)

(2020) Fang‑Liang Huang et al.   Oncology Letters

Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model

(2020) Gilseung Park et al.   Oncotarget

Efficient targeted integration directed by short homology in zebrafish and mammalian cells

(2020) Wesley A Wierson et al.   eLife

Treatment of Relapsed Acute Myeloid Leukemia

(2020) Felicitas Thol et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia

(2020) Anuradha Kirtonia et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models

(2020) Siebe Loontiens et al.   LEUKEMIA

Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis

(2019) Leslie O. Goodwin et al.   GENOME RESEARCH

DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia

(2019) Jonathan Bond et al.   HAEMATOLOGICA

New insights into the biology of acute myeloid leukemia with mutated NPM1

(2019) Lorenzo Brunetti et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Targeting FLT3 mutations in AML: review of current knowledge and evidence

(2019) Naval Daver et al.   LEUKEMIA

CSF3R mutations were associated with an unfavorable prognosis in patients with acute myeloid leukemia with CEBPA double mutations

(2019) Long Su et al.   ANNALS OF HEMATOLOGY

Current status and new treatment approaches in TP53 mutated AML

(2019) Anthony M. Hunter et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice

(2019) A.P. Lange et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1

(2019) Karina Barbosa et al.   EXPERIMENTAL HEMATOLOGY

Allogeneic hematopoietic cell transplantation compared to chemotherapy consolidation in older acute myeloid leukemia (AML) patients 60–75 years in first complete remission (CR1): an alliance (A151509), SWOG, ECOG-ACRIN, and CIBMTR study

(2019) Celalettin Ustun et al.   LEUKEMIA

EGFR is required for Wnt9a–Fzd9b signalling specificity in haematopoietic stem cells

(2019) Stephanie Grainger et al.   NATURE CELL BIOLOGY

Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish

(2019) Yanqi Xie et al.   Scientific Reports

Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

(2019) Maria Solovey et al.   Journal of Hematology & Oncology

Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies

(2019) Luiza Handschuh   Journal of Oncology

Zebrafish earn their drug discovery stripes

(2019) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Gain‐of‐Function Effects of N‐Terminal CEBPA Mutations in Acute Myeloid Leukemia

(2019) Luisa Schmidt et al.   BIOESSAYS

Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity

(2019) Vinothkumar Rajan et al.   HAEMATOLOGICA

Are Leukaemic Stem Cells Restricted to a Single Cell Lineage?

(2019) Geoffrey Brown et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Allogeneic Transplantation for Acute Myelogenous Leukemia in CR1

(2018) Elihu Estey   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CSF3R mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia

(2018) Yang Zhang et al.   CANCER

Molecular targeted therapy: treating cancer with specificity

(2018) Yeuan Ting Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPA

(2018) Feng-Ming Tien et al.   HAEMATOLOGICA

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia

(2018) Elaine G. Garcia et al.   LEUKEMIA

The Molecular Pathology of Myelodysplastic Syndrome

(2018) Torsten Haferlach   PATHOBIOLOGY

Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPA

(2018) Feng-Ming Tien et al.   HAEMATOLOGICA

Patterns of mutations in TP53 mutated AML

(2018) John S. Welch   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis

(2018) Chiara Borga et al.   LEUKEMIA

Myelodysplastic Syndrome Updated

(2018) Robert P. Hasserjian   PATHOBIOLOGY

Zebrafish: Speeding Up the Cancer Drug Discovery Process

(2018) Patricia Letrado et al.   CANCER RESEARCH

Extramedullary acute myeloid leukemia presenting in young adults demonstrates sensitivity to high dose anthracycline: subset analysis from ECOG-ACRIN 1900

(2018) Hugo F. Fernandez et al.   HAEMATOLOGICA

Molecularly distinct models of zebrafish Myc-induced B cell leukemia

(2018) Chiara Borga et al.   LEUKEMIA

An efficient method to generate xenograft tumor models of acute myeloid leukemia and hepatocellular carcinoma in adult zebrafish

(2018) Nusrat Khan et al.   BLOOD CELLS MOLECULES AND DISEASES

Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish

(2017) F Zhao et al.   LEUKEMIA

The MLL recombinome of acute leukemias in 2017

(2017) C Meyer et al.   LEUKEMIA

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

(2017) Richard M. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia

(2017) K H M Prange et al.   ONCOGENE

CRISPR Guide RNA Validation In Vitro

(2017) Stephanie Grainger et al.   Zebrafish

Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy

(2017) Germana Castelli et al.   OncoTargets and Therapy

Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish

(2017) J-W Lu et al.   Blood Cancer Journal

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

TP53mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomes

(2016) Tapan M. Kadia et al.   CANCER

CREB engages C/EBPδ to initiate leukemogenesis

(2016) C Tregnago et al.   LEUKEMIA

Overexpression of FLT3-ITD driven by spi-1 results in expanded myelopoiesis with leukemic phenotype in zebrafish

(2016) J-W Lu et al.   LEUKEMIA

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

‘Acute myeloid leukemia: a comprehensive review and 2016 update’

(2016) I De Kouchkovsky et al.   Blood Cancer Journal

Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells

(2016) Stephanie Grainger et al.   Cell Reports

Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System

(2016) Gary Alan Barclay Armstrong et al.   PLoS One

Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model

(2016) Miriam de Boeck et al.   Scientific Reports

Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo

(2015) E. Butko et al.   DEVELOPMENT

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

(2015) Julien Ablain et al.   DEVELOPMENTAL CELL

Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98–HOXA9-induced myeloid disease

(2015) A P Deveau et al.   LEUKEMIA

A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease

(2015) X Peng et al.   LEUKEMIA

Genomic landscape of cutaneous T cell lymphoma

(2015) Jaehyuk Choi et al.   NATURE GENETICS

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

(2014) B.-L. He et al.   BLOOD

Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation

(2014) Jessica S. Blackburn et al.   CANCER CELL

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia

(2014) V. L. Bentley et al.   HAEMATOLOGICA

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia

(2014) C Reynolds et al.   LEUKEMIA

Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering

(2014) Yukiko Kimura et al.   Scientific Reports

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ -catenin signaling pathway

(2013) Y. Zhang et al.   BLOOD

Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics

(2013) Li Chen et al.   BMC CANCER

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos

(2013) Nannan Chang et al.   CELL RESEARCH

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish

(2013) A. Hruscha et al.   DEVELOPMENT

A large-scale zebrafish gene knockout resource for the genome-wide study of gene function

(2013) G. K. Varshney et al.   GENOME RESEARCH

The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest

(2013) R. Ben Abdelali et al.   HAEMATOLOGICA

Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway

(2013) E Alghisi et al.   LEUKEMIA

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish

(2013) An Xiao et al.   NUCLEIC ACIDS RESEARCH

Efficient Methods for Targeted Mutagenesis in Zebrafish Using Zinc-Finger Nucleases: Data from Targeting of Nine Genes Using CompoZr or CoDA ZFNs

(2013) Raman Sood et al.   PLoS One

MYCN Transgenic Zebrafish Model with the Characterization of Acute Myeloid Leukemia and Altered Hematopoiesis

(2013) Li-Jing Shen et al.   PLoS One

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

(2013) Li-En Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development

(2013) Celia E. Shiau et al.   Cell Reports

Zebrafish screen identifies novel compound with selective toxicity against leukemia

(2012) S. Ridges et al.   BLOOD

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia

(2012) M. Luesink et al.   BLOOD

Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

(2012) Kathryn G. Roberts et al.   CANCER CELL

Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish

(2012) S. M. N. Onnebo et al.   HAEMATOLOGICA

Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen

(2012) Matthew F. Cusick et al.   JOURNAL OF NEUROIMMUNOLOGY

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

(2012) J S Blackburn et al.   LEUKEMIA

A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening

(2012) Da-Woon Jung et al.   Molecular BioSystems

A Knock-In Npm1 Mutation in Mice Results in Myeloproliferation and Implies a Perturbation in Hematopoietic Microenvironment

(2012) Shiu-Huey Chou et al.   PLoS One

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF  interaction

(2012) L. Cunningham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cpsf1 is required for definitive HSC survival in zebrafish

(2011) N. Bolli et al.   BLOOD

Leukaemia xenotransplantation in zebrafish - chemotherapy response assay in vivo

(2011) Dale P. Corkery et al.   BRITISH JOURNAL OF HAEMATOLOGY

NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis

(2011) A. Michael Forrester et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia

(2011) Jana Marková et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy

(2011) B. Pruvot et al.   HAEMATOLOGICA

Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile

(2011) Ardian Latifi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

(2011) Ching-Hon Pui et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival

(2011) Max S. Topp et al.   JOURNAL OF CLINICAL ONCOLOGY

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

(2011) Alejandro Gutierrez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

(2011) B V Balgobind et al.   LEUKEMIA

Heritable gene targeting in zebrafish using customized TALENs

(2011) Peng Huang et al.   NATURE BIOTECHNOLOGY

Targeted gene disruption in somatic zebrafish cells using engineered TALENs

(2011) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

(2011) Christopher N Hahn et al.   NATURE GENETICS

Cytarabine Dose for Acute Myeloid Leukemia

(2011) Bob Löwenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia

(2010) A. C. H. Smith et al.   BLOOD

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish

(2010) N. Bolli et al.   BLOOD

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

(2010) Hui Feng et al.   CANCER CELL

Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

(2010) Y. Wang et al.   DEVELOPMENT

Hematopoietic development in the zebrafish

(2010) Elizabeth J. Paik et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group

(2010) Torsten Haferlach et al.   JOURNAL OF CLINICAL ONCOLOGY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nucleolar protein B23 has molecular chaperone activities

(2010) Attila Szebeni et al.   PROTEIN SCIENCE

LIMK1 and LIMK2 Are Important for Metastatic Behavior and Tumor Cell-Induced Angiogenesis of Pancreatic Cancer Cells

(2010) Danielle H. Vlecken et al.   Zebrafish

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: An overview with emphasis on the myeloid neoplasms

(2009) James W. Vardiman   CHEMICO-BIOLOGICAL INTERACTIONS

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages

(2009) Chris Hall et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

(2009) I. Radtke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimal induction and post-remission therapy for AML in first remission

(2009) J. M. Rowe   Hematology-American Society of Hematology Education Program

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

(2008) Julia Zhuravleva et al.   BRITISH JOURNAL OF HAEMATOLOGY

Temozolomide-Mediated Radiosensitization of Human Glioma Cells in a Zebrafish Embryonic System

(2008) G. A. Geiger et al.   CANCER RESEARCH

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia

(2008) Sebastian Scholl et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates

(2008) A. J. Vilella et al.   GENOME RESEARCH

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

(2008) Yannick Doyon et al.   NATURE BIOTECHNOLOGY

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

(2008) Maria Emanuela Cuomo et al.   NATURE CELL BIOLOGY