Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish

(2013) S. Choorapoikayil et al.   BLOOD

Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling

(2012) S. J. Taylor et al.   BLOOD

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

(2012) N. A. Zorko et al.   BLOOD

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

(2012) S. Greenblatt et al.   BLOOD

Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

(2012) C. H. Man et al.   BLOOD

Myelopoiesis during Zebrafish Early Development

(2012) Jin Xu et al.   Journal of Genetics and Genomics

FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia

(2012) A Y H Leung et al.   LEUKEMIA

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

(2012) Catherine C. Smith et al.   NATURE

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis

(2011) Y. Zhang et al.   BLOOD

Sumoylation of CCAAT/enhancer-binding protein   promotes the biased primitive hematopoiesis of zebrafish

(2011) H. Yuan et al.   BLOOD

A potential therapeutic target for FLT3-ITD AML: PIM1 kinase

(2011) Amir T. Fathi et al.   LEUKEMIA RESEARCH

Macrophage-specific gene functions in Spi1-directed innate immunity

(2010) A. Zakrzewska et al.   BLOOD

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish

(2010) N. Bolli et al.   BLOOD

Zebrafish as a model for vertebrate hematopoiesis

(2010) Felix Ellett et al.   CURRENT OPINION IN PHARMACOLOGY

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells

(2009) N. Buza-Vidas et al.   BLOOD

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

The role of survivin2 in primitive hematopoiesis during zebrafish development

(2009) A C H Ma et al.   LEUKEMIA

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model

(2008) L. Li et al.   BLOOD

Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish

(2007) Annemarie H. Meijer et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene

(2007) Chie Nishioka et al.   LEUKEMIA RESEARCH

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols