A Roadmap for the Molecular Farming of Viral Glycoprotein Vaccines: Engineering Glycosylation and Glycosylation-Directed Folding
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Title
A Roadmap for the Molecular Farming of Viral Glycoprotein Vaccines: Engineering Glycosylation and Glycosylation-Directed Folding
Authors
Keywords
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Journal
Frontiers in Plant Science
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-12-03
DOI
10.3389/fpls.2020.609207
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Note: Only part of the references are listed.- Co‐expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants
- (2020) E Margolin et al. PLANT BIOTECHNOLOGY JOURNAL
- Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies
- (2020) Zachary A. Silver et al. Cell Reports
- Engineering the Plant Secretory Pathway for the Production of Next-Generation Pharmaceuticals
- (2020) Emmanuel A. Margolin et al. TRENDS IN BIOTECHNOLOGY
- Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
- (2020) Lucy Rutten et al. Cell Reports
- Efficient N-Glycosylation of the Heavy Chain Tailpiece Promotes the Formation of Plant-Produced Dimeric IgA
- (2020) Kathrin Göritzer et al. Frontiers in Chemistry
- Iminosugars: a host-targeted approach to combat Flaviviridae infections
- (2020) Lisa Evans DeWald et al. ANTIVIRAL RESEARCH
- Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor
- (2020) Peng Zhao et al. Cell Host & Microbe
- Exploitation of glycosylation in enveloped virus pathobiology
- (2019) Yasunori Watanabe et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Protein Quality Control in the Endoplasmic Reticulum
- (2019) Benjamin M. Adams et al. PROTEIN JOURNAL
- Engineering the interactions between a plant‐produced HIV antibody and human Fc receptors
- (2019) Szymon Stelter et al. PLANT BIOTECHNOLOGY JOURNAL
- In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants
- (2019) Jonathan Hurtado et al. PLANT BIOTECHNOLOGY JOURNAL
- Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults
- (2019) Stéphane Pillet et al. PLoS One
- In Planta Glycan Engineering and Functional Activities of IgE Antibodies
- (2019) Laura Montero-Morales et al. Frontiers in Bioengineering and Biotechnology
- Multiple roles for HIV broadly neutralizing antibodies
- (2019) Barton F. Haynes et al. Science Translational Medicine
- Production and Immunogenicity of Soluble Plant-Produced HIV-1 Subtype C Envelope gp140 Immunogens
- (2019) Emmanuel Margolin et al. Frontiers in Plant Science
- Molecular Pharming for low and middle income countries
- (2019) Sheeba Murad et al. CURRENT OPINION IN BIOTECHNOLOGY
- Cryo–electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B
- (2019) Ana S. Ramírez et al. SCIENCE
- Structure and Immune Recognition of the HIV Glycan Shield
- (2018) Max Crispin et al. Annual Review of Biophysics
- Protein Quality Control in the Endoplasmic Reticulum of Plants
- (2018) Richard Strasser Annual Review of Plant Biology
- Harnessing post-translational modifications for next-generation HIV immunogens
- (2018) Joel D. Allen et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines
- (2018) Felix A. Rey et al. CELL
- CRISPR/Cas9-mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β-1,2-xylose and core α-1,3-fucose
- (2018) Julia Jansing et al. PLANT BIOTECHNOLOGY JOURNAL
- Plant-made E2 glycoprotein single-dose vaccine protects pigs against classical swine fever
- (2018) Richard C. Laughlin et al. PLANT BIOTECHNOLOGY JOURNAL
- An oligosaccharyltransferase from Leishmania major increases the N-glycan occupancy on recombinant glycoproteins produced in Nicotiana benthamiana
- (2018) Alexandra Castilho et al. PLANT BIOTECHNOLOGY JOURNAL
- Production of complex viral glycoproteins in plants as vaccine immunogens
- (2018) Emmanuel Margolin et al. PLANT BIOTECHNOLOGY JOURNAL
- Structure of the Lassa virus glycan shield provides a model for immunological resistance
- (2018) Yasunori Watanabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
- (2018) Anita Sarkar et al. Nature Communications
- Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
- (2018) Liwei Cao et al. Nature Communications
- Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen
- (2018) Weston B. Struwe et al. Cell Reports
- Chimaeric Rift Valley Fever Virus-Like Particle Vaccine Candidate Production in Nicotiana benthamiana
- (2018) Sandiswa Mbewana et al. Biotechnology Journal
- Recent progress in broadly neutralizing antibodies to HIV
- (2018) Devin Sok et al. NATURE IMMUNOLOGY
- Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
- (2018) Talar Tokatlian et al. SCIENCE
- Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1
- (2017) Anna-Janina Behrens et al. Expert Review of Proteomics
- Native-like Env trimers as a platform for HIV-1 vaccine design
- (2017) Rogier W. Sanders et al. IMMUNOLOGICAL REVIEWS
- A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus
- (2017) Nicholas C. Wu et al. JOURNAL OF MOLECULAR BIOLOGY
- Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency
- (2017) Yen-Wen Huang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Immunogenicity of plant-produced African horse sickness virus-like particles: implications for a novel vaccine
- (2017) Susan J. Dennis et al. PLANT BIOTECHNOLOGY JOURNAL
- Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice
- (2017) Ming Yang et al. PLANT BIOTECHNOLOGY JOURNAL
- Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint
- (2017) Pietro Roversi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparison of N - and O -linked glycosylation patterns of ebolavirus glycoproteins
- (2017) Amanda L. Collar et al. VIROLOGY
- A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults
- (2016) Stéphane Pillet et al. CLINICAL IMMUNOLOGY
- Iminosugars: Promising therapeutics for influenza infection
- (2016) Beatrice Ellen Tyrrell et al. CRITICAL REVIEWS IN MICROBIOLOGY
- Protein quality control at the endoplasmic reticulum
- (2016) K. McCaffrey et al. Essays in Biochemistry
- Plant protein glycosylation
- (2016) Richard Strasser GLYCOBIOLOGY
- Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus
- (2016) Shu Shen et al. JOURNAL OF GENERAL VIROLOGY
- Reduced paucimannosidicN-glycan formation by suppression of a specific β-hexosaminidase fromNicotiana benthamiana
- (2016) Yun-Ji Shin et al. PLANT BIOTECHNOLOGY JOURNAL
- Engineering of complex protein sialylation in plants
- (2016) Somanath Kallolimath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Monoclonal antibody therapy for Junin virus infection
- (2016) Larry Zeitlin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment
- (2016) G. P. Lomonossoff et al. SCIENCE
- Transient Glyco-Engineering to Produce Recombinant IgA1 with Defined N- and O-Glycans in Plants
- (2016) Martina Dicker et al. Frontiers in Plant Science
- Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity
- (2015) Amber N. Murray et al. CHEMISTRY & BIOLOGY
- A sweet code for glycoprotein folding
- (2015) Julio J. Caramelo et al. FEBS LETTERS
- Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env
- (2015) Ivelin S. Georgiev et al. JOURNAL OF VIROLOGY
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- (2015) Christopher Mason et al. MOLECULES
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- (2015) Stephen J. Streatfield et al. PLANT BIOTECHNOLOGY JOURNAL
- Commercial-scale biotherapeutics manufacturing facility for plant-made pharmaceuticals
- (2015) Barry R. Holtz et al. PLANT BIOTECHNOLOGY JOURNAL
- Characterization of plants expressing the human β1,4-galactosyltrasferase gene
- (2015) Jeannine Schneider et al. PLANT PHYSIOLOGY AND BIOCHEMISTRY
- An intrinsic mechanism of secreted protein aging and turnover
- (2015) Won Ho Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262
- (2015) Leopold Kong et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets
- (2015) S. Pillet et al. VACCINE
- Contribution of N-linked glycans on HSV-2 gB to cell–cell fusion and viral entry
- (2015) Sukun Luo et al. VIROLOGY
- N-Glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential
- (2015) Krystal Teasley Hamorsky et al. Scientific Reports
- Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design
- (2015) Shailendra Kumar Sharma et al. Cell Reports
- Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs
- (2015) Marnie L. Fusco et al. PLoS Pathogens
- Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion
- (2014) Koh Takeda et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- O-Linked Glycosylation of the Mucin Domain of the Herpes Simplex Virus Type 1-specific Glycoprotein gC-1 Is Temporally Regulated in a Seed-and-spread Manner
- (2014) Rickard Nordén et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Plasticity of the Semliki Forest Virus Glycome upon Interspecies Transmission
- (2014) Max Crispin et al. JOURNAL OF PROTEOME RESEARCH
- Spatial Localization of the Ebola Virus Glycoprotein Mucin-Like Domain Determined by Cryo-Electron Tomography
- (2014) E. E. H. Tran et al. JOURNAL OF VIROLOGY
- Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants
- (2014) François Le Mauff et al. PLANT BIOTECHNOLOGY JOURNAL
- Proteolytic and N-Glycan Processing of Human 1-Antitrypsin Expressed in Nicotiana benthamiana
- (2014) A. Castilho et al. PLANT PHYSIOLOGY
- Host Controls of HIV Neutralizing Antibodies
- (2014) B. F. Haynes et al. SCIENCE
- Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines
- (2014) Brian J. Ward et al. VACCINE
- Drug levels, anti-drug antibodies, and clinical efficacy of the anti-TNFα biologics in rheumatic diseases
- (2013) C. C. Mok et al. CLINICAL RHEUMATOLOGY
- Anti-drug antibodies in psoriasis: a critical evaluation of clinical significance and impact on treatment response
- (2013) Leeyen Hsu et al. Expert Review of Clinical Immunology
- The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody
- (2013) Bo Liu et al. JOURNAL OF BIOTECHNOLOGY
- Glycosylation of closely spaced acceptor sites in human glycoproteins
- (2013) S. Shrimal et al. JOURNAL OF CELL SCIENCE
- Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16
- (2013) Marie Pancera et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A method for rapid production of heteromultimeric protein complexes in plants: assembly of protective bluetongue virus-like particles
- (2013) Eva C. Thuenemann et al. PLANT BIOTECHNOLOGY JOURNAL
- Rapid High-Level Production of Functional HIV Broadly Neutralizing Monoclonal Antibodies in Transient Plant Expression Systems
- (2013) Yvonne Rosenberg et al. PLoS One
- Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents
- (2013) Jinhong Chang et al. Emerging Microbes & Infections
- Setting up a platform for plant-based influenza virus vaccine production in South Africa
- (2012) Elizabeth Mortimer et al. BMC BIOTECHNOLOGY
- Engineering of Sialylated Mucin-typeO-Glycosylation in Plants
- (2012) Alexandra Castilho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Engineering Mammalian Mucin-typeO-Glycosylation in Plants
- (2012) Zhang Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Marketing approval of mogamulizumab
- (2012) Alain Beck et al. mAbs
- Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants
- (2012) Juliana Parsons et al. PLANT BIOTECHNOLOGY JOURNAL
- Reduction of Plant-Specific Arabinogalactan-TypeO-Glycosylation by Treating Tobacco Plants with Ferrous Chelator 2,2′-Dipyridyl
- (2011) Ryo MORIGUCHI et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- N-Glycosylation engineering of plants for the biosynthesis of glycoproteins with bisected and branched complex N-glycans
- (2011) Alexandra Castilho et al. GLYCOBIOLOGY
- β-N-Acetylhexosaminidases HEXO1 and HEXO3 Are Responsible for the Formation of PaucimannosidicN-Glycans inArabidopsis thaliana
- (2011) Eva Liebminger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oligosaccharyltransferase: the central enzyme of N-linked protein glycosylation
- (2011) Elisabeth Mohorko et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Role of malectin in Glc2Man9GlcNAc2-dependent quality control of α1-antitrypsin
- (2011) Yang Chen et al. MOLECULAR BIOLOGY OF THE CELL
- Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice
- (2011) Julia Pinkhasov et al. PLANT BIOTECHNOLOGY JOURNAL
- Production of Complex Multiantennary N-Glycans in Nicotiana benthamiana Plants
- (2011) B. Nagels et al. PLANT PHYSIOLOGY
- Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid -peptides in human cerebrospinal fluid
- (2011) A. Halim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction
- (2011) Xin Huang et al. VIROLOGY
- Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins - towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation
- (2010) Sasha M Daskalova et al. BMC BIOTECHNOLOGY
- Plant glycans: friend or foe in vaccine development?
- (2010) Dirk Bosch et al. Expert Review of Vaccines
- In PlantaProtein Sialylation through Overexpression of the Respective Mammalian Pathway
- (2010) Alexandra Castilho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain
- (2010) Guennadi Kozlov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Plant-made vaccines for humans and animals
- (2010) Edward P. Rybicki PLANT BIOTECHNOLOGY JOURNAL
- The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza
- (2010) Marc-André D’Aoust et al. PLANT BIOTECHNOLOGY JOURNAL
- Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza
- (2010) Nathalie Landry et al. PLoS One
- Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms
- (2009) Catalina Ruiz-Canada et al. CELL
- Plants as biofactories for the production of subunit vaccines against bio-security-related bacteria and viruses☆
- (2009) M. Manuela Rigano et al. VACCINE
- Crystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine Design
- (2008) T. A. Bowden et al. JOURNAL OF VIROLOGY
- Malectin: A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein N-Glycosylation
- (2008) Thomas Schallus et al. MOLECULAR BIOLOGY OF THE CELL
- Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice
- (2008) Marc-André D’Aoust et al. PLANT BIOTECHNOLOGY JOURNAL
- Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure
- (2008) Richard Strasser et al. PLANT BIOTECHNOLOGY JOURNAL
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