Transient Glyco-Engineering to Produce Recombinant IgA1 with Defined N- and O-Glycans in Plants

Paradigm shift in activity assessment of IgA nephropathy – optimizing the next generation of diagnostic and therapeutic maneuvers via glycan targeting

(2015) Yusuke Suzuki et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Fc glycans of therapeutic antibodies as critical quality attributes

(2015) Dietmar Reusch et al.   GLYCOBIOLOGY

Site-Specific Glycosylation of Secretory Immunoglobulin A from Human Colostrum

(2015) Jincui Huang et al.   JOURNAL OF PROTEOME RESEARCH

Processing of complex N-glycans in IgG Fc-region is affected by core fucosylation

(2015) Alexandra Castilho et al.   mAbs

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

(2015) Julian K-C. Ma et al.   PLANT BIOTECHNOLOGY JOURNAL

A common glycan structure on immunoglobulin G for enhancement of effector functions

(2015) Chin-Wei Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Role of Antibody N-Glycosylation in Receptor Interactions

(2015) Ganesh P. Subedi et al.   STRUCTURE

Obinutuzumab (GA101) for the Treatment of Chronic Lymphocytic Leukemia and Other B-Cell Non-Hodgkin's Lymphomas: A Glycoengineered Type II CD20 Antibody

(2015) Valentin Goede et al.   Oncology Research and Treatment

Upstream and downstream processing of recombinant IgA

(2014) David Reinhart et al.   BIOTECHNOLOGY LETTERS

Controlled glycosylation of plant-produced recombinant proteins

(2014) Richard Strasser et al.   CURRENT OPINION IN BIOTECHNOLOGY

Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis

(2014) Yun Kong et al.   GLYCOBIOLOGY

Identification of Novel Peptidyl Serine α-Galactosyltransferase Gene Family in Plants

(2014) Fumie Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins

(2014) Alysia A. Ahmed et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV

(2014) Matthew Paul et al.   mAbs

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

(2014) Xiangguo Qiu et al.   NATURE

Genentech's glyco-engineered antibody to succeed Rituxan

(2014) Mark Ratner   NATURE BIOTECHNOLOGY

Monomeric IgA can be producedin plantaas efficient as IgG, yet receives differentN-glycans

(2014) Lotte B. Westerhof et al.   PLANT BIOTECHNOLOGY JOURNAL

Proteolytic and N-Glycan Processing of Human  1-Antitrypsin Expressed in Nicotiana benthamiana

(2014) A. Castilho et al.   PLANT PHYSIOLOGY

Expression and glycoengineering of functionally active heteromultimeric IgM in plants

(2014) A. Loos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgAEGFR antibodies mediate tumour killingin vivo

(2013) Peter Boross et al.   EMBO Molecular Medicine

Combinatorial Analysis of Secretory Immunoglobulin A (sIgA) Expression in Plants

(2013) Paloma Juarez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional Identification of a Hydroxyproline-O-galactosyltransferase Specific for Arabinogalactan Protein Biosynthesis inArabidopsis

(2013) Debarati Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A gene responsible for prolyl-hydroxylation of moss-produced recombinant human erythropoietin

(2013) Juliana Parsons et al.   Scientific Reports

Engineering of Sialylated Mucin-typeO-Glycosylation in Plants

(2012) Alexandra Castilho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Mammalian Mucin-typeO-Glycosylation in Plants

(2012) Zhang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombinant jacalin-like plant lectins are produced at high levels in Nicotiana benthamiana and retain agglutination activity and sugar specificity

(2012) Asun Fernandez-del-Carmen et al.   JOURNAL OF BIOTECHNOLOGY

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Glycosylation of IgA1 and pathogenesis of IgA nephropathy

(2012) Jan Novak et al.   Seminars in Immunopathology

Engineering of human-type O-glycosylation inNicotiana benthamianaplants

(2012) Richard Strasser   Bioengineered

Glycosides of hydroxyproline: Some recent, unusual discoveries

(2011) C. M. Taylor et al.   GLYCOBIOLOGY

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Immunoglobulin A

(2011) Jantine E. Bakema et al.   mAbs

Neutralizing antibodies against rotavirus produced in transgenically labelled purple tomatoes

(2011) Paloma Juárez et al.   PLANT BIOTECHNOLOGY JOURNAL

Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice

(2011) Julia Pinkhasov et al.   PLANT BIOTECHNOLOGY JOURNAL

Rapid High Yield Production of Different Glycoforms of Ebola Virus Monoclonal Antibody

(2011) Alexandra Castilho et al.   PLoS One

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In PlantaProtein Sialylation through Overexpression of the Respective Mammalian Pathway

(2010) Alexandra Castilho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fc-Glycosylation Influences Fc  Receptor Binding and Cell-Mediated Anti-HIV Activity of Monoclonal Antibody 2G12

(2010) D. N. Forthal et al.   JOURNAL OF IMMUNOLOGY

Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell lines

(2010) Esther M. Yoo et al.   mAbs

Improved Virus Neutralization by Plant-produced Anti-HIV Antibodies with a Homogeneous β1,4-GalactosylatedN-Glycan Profile

(2009) Richard Strasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GlycoSpectrumScan: Fishing Glycopeptides from MS Spectra of Protease Digests of Human Colostrum sIgA

(2009) Nandan Deshpande et al.   JOURNAL OF PROTEOME RESEARCH

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Construction of a Functional CMP-Sialic Acid Biosynthesis Pathway in Arabidopsis

(2008) A. Castilho et al.   PLANT PHYSIOLOGY