Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

(2020) Andrey A. Parkhitko et al.   AGEING RESEARCH REVIEWS

Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas

(2019) Estela Area-Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease

(2019) Yaping Shao et al.   Molecular Neurodegeneration

A Drosophila Mitochondrial Complex I Deficiency Phenotype Array

(2019) Sarah Foriel et al.   Frontiers in Genetics

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

(2019) Yasmine J. Liu et al.   PLoS Genetics

Glycine supplementation extends lifespan of male and female mice

(2019) Richard A. Miller et al.   AGING CELL

Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo

(2019) Abby L. Olsen et al.   GLIA

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

(2019) Andrey A. Parkhitko et al.   AGING CELL

Insights from Drosophila on mitochondrial complex I

(2019) Shauna-Kay Rhooms et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

(2018) Meenakshi Ravichandran et al.   Cell Metabolism

Overexpression of Nmnat improves the adaption of health span in aging Drosophila

(2018) Xianchu Liu et al.   EXPERIMENTAL GERONTOLOGY

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

(2018) Dalila G. Ordonez et al.   NEURON

Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster

(2018) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

(2018) Stephanie Post et al.   Frontiers in Endocrinology

Mass Spectrometric Quantification of Arousal Associated Neurochemical Changes in Single Honey Bee Brains and Brain Regions

(2018) Divya Ramesh et al.   ACS Chemical Neuroscience

Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2

(2018) Stephanie Post et al.   AGING CELL

Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging

(2017) Ondine van de Rest et al.   Nutrients

Octopamine Drives Endurance Exercise Adaptations in Drosophila

(2017) Alyson Sujkowski et al.   Cell Reports

Using artificial diets to understand the nutritional physiology of Drosophila melanogaster

(2017) Matthew DW Piper   Current Opinion in Insect Science

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span inDrosophila

(2016) Andrey A. Parkhitko et al.   GENES & DEVELOPMENT

A genome-wide resource for the analysis of protein localisation in Drosophila

(2016) Mihail Sarov et al.   eLife

A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila

(2016) Jie Shen et al.   Aging-US

The effects of age and dietary restriction on the tissue-specific metabolome ofDrosophila

(2015) Matthew J. Laye et al.   AGING CELL

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

(2015) Steve Horvath et al.   Aging-US

Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

(2015) Kristopher Burkewitz et al.   CELL

Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span

(2015) Sofiya Milman et al.   Cold Spring Harbor Perspectives in Medicine

The Genomic Basis of Postponed Senescence in Drosophila melanogaster

(2015) Megan Ulmer Carnes et al.   PLoS One

Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly,Drosophila melanogaster

(2014) Jessica M. Hoffman et al.   AGING CELL

Neuronal glycogen synthesis contributes to physiological aging

(2014) Christopher Sinadinos et al.   AGING CELL

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

The Role of Nitisinone in Tyrosine Pathway Disorders

(2014) Edward Lock et al.   Current Rheumatology Reports

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

(2014) Andrei S Avanesov et al.   eLife

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

(2013) Drew Stenesen et al.   Cell Metabolism

Regulation of pyruvate metabolism and human disease

(2013) Lawrence R. Gray et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

(2013) Annabel A. Ferguson et al.   PLoS Genetics

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

A metabolic signature predicts biological age in mice

(2012) Antonia Tomás-Loba et al.   AGING CELL

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

Human serum metabolic profiles are age dependent

(2012) Zhonghao Yu et al.   AGING CELL

Enhanced Energy Metabolism Contributes to the Extended Life Span of Calorie-restrictedCaenorhabditis elegans

(2012) Yiyuan Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-related decline in mitochondrial bioenergetics: Does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?

(2012) Luis A. Gómez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

Increased transsulfuration mediates longevity and dietary restriction in Drosophila

(2011) H. Kabil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extendsDrosophilalifespan

(2010) Sepehr Bahadorani et al.   AGING CELL

A metabolic signature of long life in Caenorhabditis elegans

(2010) Silke Fuchs et al.   BMC BIOLOGY

Behavioral consequences of dopamine deficiency in the Drosophila central nervous system

(2010) T. Riemensperger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction

(2010) A. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Expression of hsp22 and hsp70 Transgenes Is Partially Predictive of Drosophila Survival Under Normal and Stress Conditions

(2009) J. Yang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Characterization of theDrosophilaGene-Switch system in aging studies: a cautionary tale

(2008) Luc Poirier et al.   AGING CELL

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span ofDrosophila melanogaster

(2008) Susan K. Legan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life Span Extension and Neuronal Cell Protection byDrosophilaNicotinamidase

(2008) Vitaly Balan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY