Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

Highly reproducible improved label-free quantitative analysis of cellular phosphoproteome by optimization of LC-MS/MS gradient and analytical column construction

(2017) Nagib Ahsan et al.   Journal of Proteomics

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress

(2017) Ivan Gusarov et al.   Nature Communications

Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila

(2017) Kento Tanabe et al.   Cell Reports

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

(2017) Bianca van Lierop et al.   Scientific Reports

Characterization of the direct targets of FOXO transcription factors throughout evolution

(2016) Ashley E. Webb et al.   AGING CELL

Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster

(2016) Lucie Kučerová et al.   BMC GENOMICS

Novel method demonstrates differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation

(2016) Anne M. Cieniewicz et al.   CELLULAR SIGNALLING

FlyBase at 25: looking to the future

(2016) L. Sian Gramates et al.   NUCLEIC ACIDS RESEARCH

An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling

(2016) Arunachalam Vinayagam et al.   Cell Reports

Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogaster

(2016) Stephanie Post et al.   PLoS One

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides

(2015) Dick R. Nässel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability

(2015) Julien Colombani et al.   CURRENT BIOLOGY

Role of glycogen phosphorylase in liver glycogen metabolism

(2015) Loranne Agius   MOLECULAR ASPECTS OF MEDICINE

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

(2015) Sean J Humphrey et al.   NATURE BIOTECHNOLOGY

Methods for studying metabolism in Drosophila

(2014) Jason M. Tennessen et al.   METHODS

Independent signaling by Drosophila insulin receptor for axon guidance and growth

(2014) Caroline R. Li et al.   Frontiers in Physiology

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila

(2013) N. Okamoto et al.   GENES & DEVELOPMENT

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction

(2013) Kavitha Kannan et al.   Frontiers in Physiology

IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor

(2013) Soetkin Versteyhe et al.   Frontiers in Endocrinology

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

Acetylation Negatively Regulates Glycogen Phosphorylase by Recruiting Protein Phosphatase 1

(2012) Tengfei Zhang et al.   Cell Metabolism

Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

(2012) Dara Hope Cohen et al.   ENDOCRINE-RELATED CANCER

Systematic Evaluation of the Metabolic to Mitogenic Potency Ratio for B10-Substituted Insulin Analogues

(2012) Tine Glendorf et al.   PLoS One

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances

(2012) Kenneth Siddle   Frontiers in Endocrinology

C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane

(2011) Xiangyang Xie et al.   Cell Metabolism

Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)

(2011) Gokhan Demirkan et al.   PLoS One

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

(2010) Susan J. Broughton et al.   AGING CELL

Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer

(2010) P Massoner et al.   BRITISH JOURNAL OF CANCER

Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling

(2010) L. Sciacca et al.   DIABETOLOGIA

Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe

(2010) J. Varghese et al.   GENES & DEVELOPMENT

Structural and Biological Properties of theDrosophilaInsulin-like Peptide 5 Show Evolutionary Conservation

(2010) Waseem Sajid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin and Insulin-like Growth Factor-1 Receptors Act as Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription

(2010) Jeremie Boucher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration

(2010) Gabriel A. Quinones et al.   JOURNAL OF CELL BIOLOGY

HTAPP: High-throughput autonomous proteomic pipeline

(2010) Kebing Yu et al.   PROTEOMICS

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Molecular mechanisms of metabolic regulation by insulin inDrosophila

(2009) Aurelio A. Teleman   BIOCHEMICAL JOURNAL

CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells

(2009) R.-q. Chen et al.   CANCER RESEARCH

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

(2009) Andrew McBride et al.   Cell Metabolism

A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States

(2009) Maija Slaidina et al.   DEVELOPMENTAL CELL

A Fat Body-Derived IGF-like Peptide Regulates Postfeeding Growth in Drosophila

(2009) Naoki Okamoto et al.   DEVELOPMENTAL CELL

Integrated platform for manual and high-throughput statistical validation of tandem mass spectra

(2009) Kebing Yu et al.   PROTEOMICS

PeptideDepot: Flexible relational database for visual analysis of quantitative proteomic data and integration of existing protein information

(2009) Kebing Yu et al.   PROTEOMICS

Drosophila ALS Regulates Growth and Metabolism through Functional Interaction with Insulin-Like Peptides

(2008) Nathalie Arquier et al.   Cell Metabolism

Signaling from endosomes: Location makes a difference

(2008) Lukasz Sadowski et al.   EXPERIMENTAL CELL RESEARCH

Oxidative stress and chronological aging in glycogen-phosphorylase-deleted yeast

(2008) Cristián Favre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

(2007) Akiko Taguchi et al.   Annual Review of Physiology