Article
Biology
Pei-Heng Jiang, Chen-Yan Hou, Shu-Chun Teng
Summary: The study reveals that Ids2 is a cochaperone essential for maintaining mitochondrial DNA stability and the proteostasis of the electron transport chain. It recruits Atp3, a subunit of complex V ATP synthase, to the folding system. Deletion of IDS2 or Atp3 leads to loss of mitochondrial DNA and Yme1 plays a critical role in maintaining Atp3 protein level.
Article
Cell Biology
Diana Bou-Teen, Celia Fernandez-Sanz, Elisabet Miro-Casas, Zuzana Nichtova, Elena Bonzon-Kulichenko, Kelly Casos, Javier Inserte, Antonio Rodriguez-Sinovas, Begona Benito, Shey-Shing Sheu, Jesus Vazquez, Ignacio Ferreira-Gonzalez, Marisol Ruiz-Meana
Summary: Aging impairs the dimerization of FoF1-ATP synthase in aged cardiomyocytes, leading to abnormal mitochondrial cristae morphology and reduced energy efficiency. This defect increases the susceptibility of cardiomyocytes to undergo energy collapse and mitochondrial failure.
Article
Neurosciences
Tao Gong, Steve C. N. Hui, Helge J. Zollner, Mark Britton, Yulu Song, Yufan Chen, Aaron T. Gudmundson, Kathleen E. Hupfeld, Christopher W. Davies-Jenkins, Saipavitra Murali-Manohar, Eric C. Porges, Georg Oeltzschner, Weibo Chen, Guangbin Wang, Richard A. E. Edden
Summary: The neurometabolic changes as a function of age were investigated in a large cohort of male and female subjects using consensus-recommended magnetic resonance spectroscopy quantification methods. The results showed that certain metabolites in different brain regions had significant correlations with age, while no age correlations were found for other metabolites. These findings provide a normative foundation for future research on the neurometabolic time course of healthy aging using MRS.
Article
Oncology
Lisa Maria Walchhofer, Ruth Steiger, Andreas Rietzler, Johannes Kerschbaumer, Christian Franz Freyschlag, Guenther Stockhammer, Elke Ruth Gizewski, Astrid Ellen Grams
Summary: This study used phosphorus magnetic resonance spectroscopy to demonstrate regional differences in energy and membrane metabolism in patients with naive glioblastoma multiforme. The method showed differences not only in affected regions of the brain but also in distant regions, opposite brain hemisphere, and compared to healthy volunteers. Further research is needed to evaluate differences between genetic mutations and clinical applicability for follow-up monitoring in larger cohorts.
Article
Neurosciences
Geraldine Rodriguez-Nieto, Oron Levin, Lize Hermans, Akila Weerasekera, Anca Croitor Sava, Astrid Haghebaert, Astrid Huybrechts, Koen Cuypers, Dante Mantini, Uwe Himmelreich, Stephan P. Swinnen
Summary: Aging is associated with structural and metabolic changes in the brain. Previous research has focused on individual brain regions, but the relationship among metabolites across the brain has been less studied. Using 1H-MRS, this study investigated the relationship among metabolite concentrations in different brain regions in young and older adults. The results showed age-related differences in metabolite concentrations and revealed associative patterns between metabolites across brain regions, which differed between age groups.
Article
Multidisciplinary Sciences
Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S Bouchard, Liming Xia, Xin Zhou
Summary: The recovery process of COVID-19 patients remains unclear, with some experiencing ongoing respiratory issues. Xe-129 MRI analysis reveals higher ventilation defects and longer gas-blood exchange time in COVID-19 patients, indicating lung function impairment during recovery.
Review
Biochemistry & Molecular Biology
Benjamin Matis Pizarro-Galleguillos, Liesa Kunert, Norbert Brueggemann, Jannik Prasuhn
Summary: This review emphasizes the biological rationale for studying the pathways of Parkinson's disease and discusses the application of various neuroimaging methods in patients, as well as the limitations and challenges that need to be overcome for successful implementation in clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Steve C. N. Hui, Helge J. Zollner, Tao Gong, Kathleen E. Hupfeld, Aaron T. Gudmundson, Saipavitra Murali-Manohar, Christopher W. Davies-Jenkins, Yulu Song, Yufan Chen, Georg Oeltzschner, Guangbin Wang, Richard A. E. Edden
Summary: This study compared the abilities of PRESS and sLASER to reveal the relationships between brain metabolites and age. The results showed that both methods performed similarly in identifying these relationships, but sLASER was technically more desirable due to its reduced chemical shift displacement artifact.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Food Science & Technology
Greta Bischof, Franziska Witte, Thorben Sieksmeyer, Edwin Januschweski, Nino Terjung, Christian Hertel, Volker Heinz, Andreas Juadjur, Monika Gibis
Summary: This study investigates the effects of aging and microbial growth on the metabolome of aged beef. The aging method applied to beef affects its metabolome, which includes changes in metabolism during aging and the presence of microorganisms on the beef that may impact its quality. The metabolome of dry-aged and wet-aged beef at different sampling locations shows changes over time, with the influence of microbiota being negligible on the surface of dry-aged beef. The concentrations of amino acids and inosine differ significantly between the two aging methods, indicating variations in protein degradation and energy metabolism.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Clinical Neurology
Thomas Payne, Toby Burgess, Stephen Bradley, Sarah Roscoe, Matilde Sassani, Mark J. Dunning, Dena Hernandez, Sonja Scholz, Alisdair McNeill, Rosie Taylor, Li Su, Iain Wilkinson, Thomas Jenkins, Heather Mortiboys, Oliver Bandmann
Summary: This study characterized bioenergetic dysfunction in Parkinson's disease using a multimodal approach, and found impaired mitophagy and mitochondrial uncoupling in patient-derived fibroblasts. The study also revealed abnormal phosphocreatine levels and implicated a link between impaired mitophagy and impaired striatal energy homeostasis in early Parkinson's disease.
Review
Biochemistry & Molecular Biology
Ming Yang, Shilu Luo, Wei Chen, Liyu He, Di Liu, Xi Wang, Li Xiao, Lin Sun
Summary: Mitochondrial unfolded protein response (mtUPR) is a mechanism for regulating cellular homeostasis, and its abnormalities are closely associated with the development of diseases. This article summarizes the pathways and potential therapeutic targets of mtUPR, and discusses its role in disease progression.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Jaqueline Aragoni da Silva, Laurent O. Martinez, Yves Rolland, Souad Najib, Mikael Croyal, Bertrand Perret, Nabila Jabrane-Ferrat, Hicham El Costa, Sophie Guyonnet, Bruno Vellas, Philipe de Souto Barreto, MAPT DSA grp
Summary: This study investigated the association between plasma levels of ATPase inhibitory factor 1 (IF1) and intrinsic capacity (IC) in community-dwelling older adults. The findings showed that plasma IF1 levels were associated with IC composite scores, with both low-intermediate and high-intermediate levels being linked to higher scores. This study is the first to demonstrate the relationship between circulating IF1 levels and IC in older adults, but further research is needed to understand the underlying mechanisms.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Physics, Multidisciplinary
C. Munuera-Javaloy, A. Tobalina, J. Casanova
Summary: Ensembles of nitrogen-vacancy centers are used to detect nuclear magnetic resonance signals from micron-sized samples. The large magnetic field regime is of particular interest due to the high thermal polarization and accessibility of chemical shifts and J couplings. However, coupling NV-based sensors with high-frequency nuclear signals has been challenging. This Letter presents a method that overcomes this obstacle and achieves high spectral resolutions, limited only by the coherence of the nuclear spin signal.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
A. J. Healey, S. C. Scholten, T. Yang, J. A. Scott, G. J. Abrahams, I. O. Robertson, X. F. Hou, Y. F. Guo, S. Rahman, Y. Lu, M. Kianinia, I Aharonovich, J-P Tetienne
Summary: A versatile quantum microscope is demonstrated using point defects embedded in a thin layer of hexagonal boron nitride, allowing for real-time observation of temperature and magnetic field near the Curie temperature of a van der Waals ferromagnet, as well as mapping of charge currents and Joule heating in a graphene device. The integration of hexagonal boron nitride quantum sensor with other van der Waals materials will have significant practical benefits for the design and measurement of 2D devices.
Article
Psychiatry
Ole Kohler-Forsberg, Louisa G. Sylvia, Michael Thase, Joseph R. Calabrese, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, Dan Iosifescu, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Vicki Fung, Michael J. Ostacher, Andrew A. Nierenberg
Summary: This study found that patients with bipolar disorder who used lithium in combination with antipsychotics or anticonvulsants showed worse response compared to those who only used lithium. However, compared to lithium and anticonvulsants, the combined use of lithium and antipsychotics showed slight improvement in general and manic symptoms, but worse development in glucose, triglycerides, and metabolic syndrome.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Editorial Material
Medicine, General & Internal
Dan Iosifescu
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Environmental Sciences
Mariana Tortorelli, Telma Ramos Trigo, Renata Bolibio, Camila Colas Sabino de Freitas, Floracy Gomes Ribeiro, Mara Cristina Souza de Lucia, Dan Iosifescu, Renerio Fraguas
Summary: This study investigated the association between burnout and life events outside the workplace in nursing assistants. The results showed that an increase in the number of personal changes or difficulties was associated with increased severity of emotional exhaustion, while an increase in the number of changes in familial situation and death of relatives or friends was associated with increased severity of depersonalization.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Optics
Paolo Cassano, Richard Norton, Marco Antonio Caldieraro, Farzan Vahedifard, Fernando Vizcaino, Kayla Marie McEachern, Dan Iosifescu
Summary: This study investigates the safety profile of transcranial photobiomodulation (t-PBM) for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD). The results show that low doses of near-infrared (NIR) light can be administered with increasing frequency for several weeks without a corresponding increase in adverse events.
Review
Clinical Neurology
Zamfira Parincu, Dan V. Iosifescu
Summary: Major depressive disorder is a leading cause of disability globally. Current pharmacotherapies targeting monoamine receptors are often ineffective and slow-acting, highlighting a need for more rapid and effective treatments. Studies have shown that combining dextromethorphan with quinidine or bupropion can effectively reduce depressive symptoms in MDD, but results are mixed for TRD and bipolar depression, warranting further research.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Letter
Psychiatry
Matthew J. Hoptman, Umit Tural, Molly S. Arnold, Katherine A. Collins, Kathryn T. Evans, Molly K. Irvin, Zamfira Parincu, Danielle N. Rette, Allison M. Sparpana, Elizabeth F. Sullivan, Dan V. Iosifescu
SCHIZOPHRENIA RESEARCH
(2023)
Review
Biology
Umit Tural, Allison Sparpana, Elizabeth Sullivan, Dan V. Iosifescu
Summary: This study conducted a network meta-analysis to investigate the differences in adiponectin levels across eating disorders, obesity, constitutional thinness, and healthy controls. The results showed that participants with anorexia nervosa had significantly higher adiponectin levels, while obesity and binge-eating disorder were associated with significantly lower levels. These findings suggest that adiponectin may be an important marker of metabolic imbalance.
Article
Psychiatry
Willians Fernando Vieira, Dan Iosifescu, Kayla Marie McEachern, Maia Gersten, Paolo Cassano
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2023)
Article
Health Care Sciences & Services
Dan V. Iosifescu, Xiaotong Song, Maia B. Gersten, Arwa Adib, Yoonju Cho, Katherine M. Collins, Kathy F. Yates, Aura M. Hurtado-Puerto, Kayla M. McEachern, Ricardo S. Osorio, Paolo Cassano
Summary: This study aims to investigate the impact, safety, and mechanisms of transcranial photobiomodulation (t-PBM) on cognition in patients with amnestic mild cognitive impairment (aMCI) and early Alzheimer's disease (AD). The participants will receive 24 sessions of t-PBM treatment over 8 weeks, and the study will explore whether baseline tau burden and changes in mitochondrial function moderate the cognitive changes observed after t-PBM therapy. Additionally, changes in the fMRI blood-oxygenation-level-dependent (BOLD) signal after a single treatment will be examined to demonstrate t-PBM-dependent increases in prefrontal cortex blood flow.
Article
Psychiatry
Russell H. Tobe, Lucia Tu, John R. Keefe, Melissa M. Breland, Benjamin A. Ely, Melissa Sital, Jasmin T. Richard, Umit Tural, Dan V. Iosifescu, Vilma Gabbay
Summary: This study aims to examine the factors influencing the expression of anhedonia. By evaluating physical, developmental, and clinical measures, the study found a correlation between personality traits and anhedonia, while diagnostic and symptom measures were not significant predictors of anhedonia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Meeting Abstract
Neurosciences
Jack Grinband, Pejman Sehatpour, Daniel Javitt, Dan Iosifescu, Lawrence Kegeles, Tse Hwei Choo, Tarek Sobieh, Megan Mayer, Preetika Govil, Joshua Kantrowitz
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Dan V. Iosifescu, Richard J. Norton, Umit Tural, David Mischoulon, Katherine Collins, Erin McDonald, Luis De Taboada, Simmie Foster, Cristina Cusin, Albert Yeung, Alisabet Clain, David Schoenfeld, Michael R. Hamblin, Paolo Cassano
Summary: This double-blind, sham-controlled study tested the efficacy of low-dose transcranial photobiomodulation (t-PBM) in individuals with major depressive disorder (MDD). The results showed that low-dose t-PBM did not significantly reduce depression severity. This study provides evidence for determining the optimal dosage of t-PBM for MDD treatment.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Dan V. Iosifescu, Amanda Jones, Cedric O'Gorman, Caroline Streicher, Samantha Feliz, Maurizio Fava, Herriot Tabuteau
Summary: This study found that treatment with dextromethorphan-bupropion showed significant improvements in depressive symptoms in patients with major depressive disorder compared to placebo, with a faster onset of action and good tolerability.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Matthew Hoptman, Molly Irvin, Allison Sparpana, Elizabeth Sullivan, Molly Arnold, Katherine Collins, Dan Iosifescu
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Dan Iosifescu, Katherine Collins, Aura M. Hurtado, Jacek Dmochowski, Luis DeTaboada, Molly K. Irvin, Allison Sparpana, Elizabeth Sullivan, Xiaotong Song, Arwa Adib, Julie A. Clancy, Maia B. Gersten, Kayla M. McEachern, Paolo Cassano
BIOLOGICAL PSYCHIATRY
(2022)