Involvement of p38 MAPK in Synaptic Function and Dysfunction

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

(2020) Chuanbin Yang et al.   Redox Biology

The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications

(2020) Wenting Guo et al.   BRAIN

Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ

(2020) Arne Ittner et al.   ACTA NEUROPATHOLOGICA

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

(2019) Saktimayee M. Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory

(2019) Marta Navarrete et al.   Nature Communications

Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1

(2019) Hui Wang et al.   Evidence-based Complementary and Alternative Medicine

p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease

(2019) Chen Gui et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

RAGE mediates Aβ accumulation in a mouse model of Alzheimer’s disease via modulation of β- and γ-secretase activity

(2018) Fang Fang et al.   HUMAN MOLECULAR GENETICS

An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease

(2018) Grazia Rutigliano et al.   NEUROBIOLOGY OF AGING

Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy

(2018) Ghazaleh Kheiri et al.   REVIEWS IN THE NEUROSCIENCES

Morroniside prevents H2O2 or Aβ1–42-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation

(2018) Kang Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease

(2018) Qing Yu et al.   Nature Communications

Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour

(2018) Kristie Stefanoska et al.   Scientific Reports

p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

(2018) Matthew J. Robson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling

(2018) Przemysław Jagodzik et al.   Frontiers in Plant Science

Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer’s Disease and Brain Aging

(2017) Yu Hasegawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

(2017) Zhengqiu Zhou et al.   Journal of Neuroinflammation

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

(2017) Jong Kil Lee et al.   MOLECULES

p38 MAPK‑MK2 pathway regulates the heat‑stress‑induced accumulation of reactive oxygen species that mediates apoptotic cell death in glial cells

(2017) Hongbo Li et al.   Oncology Letters

Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer’s disease mouse model

(2017) Chiara Criscuolo et al.   Scientific Reports

Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity

(2016) Hyeon-Ju Jeong et al.   DIABETES

p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes

(2016) Ramkumar Menon et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Low-frequency stimulation induces a durable long-term depression in young adult hyperthyroid rats

(2016) Burak Tan et al.   NEUROREPORT

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

(2016) Nicole Maphis et al.   Alzheimers Research & Therapy

Do p38 mitogen-activated protein kinase inhibitors have a future for the treatment of cardiovascular disease?

(2016) Andrew R. Kompa   Journal of Thoracic Disease

p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice

(2016) Hai-long Dai et al.   Scientific Reports

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

(2015) Saktimayee M. Roy et al.   ACS Chemical Neuroscience

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

(2015) Laura Schnöder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia-Mediated Inflammation and Neurodegenerative Disease

(2015) Ling Xu et al.   MOLECULAR NEUROBIOLOGY

Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer’s disease models

(2015) I. Lonskaya et al.   NEUROSCIENCE

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

(2015) Reynolds K. Brobey et al.   PLoS One

RAGE Inhibition in Microglia Prevents Ischemia-Dependent Synaptic Dysfunction in an Amyloid-Enriched Environment

(2014) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

HMGB1 Promotes a p38MAPK Associated Non-Infectious Inflammatory Response Pathway in Human Fetal Membranes

(2014) Sarah Bredeson et al.   PLoS One

p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer’s disease

(2014) Arne A Ittner et al.   Acta Neuropathologica Communications

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

(2013) Irina Lonskaya et al.   EMBO Molecular Medicine

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

(2013) D. Martin Watterson et al.   PLoS One

Casein Kinase I  Mutations in Familial Migraine and Advanced Sleep Phase

(2013) K. C. Brennan et al.   Science Translational Medicine

Age-induced augmentation of p38 MAPK phosphorylation in mouse lung

(2011) Zongli Li et al.   EXPERIMENTAL GERONTOLOGY

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Activation of senescence and aging characteristics by mitochondrially generated ROS: How are they linked?

(2010) John Papaconstantinou et al.   CELL CYCLE

Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives  -Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

(2010) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice

(2009) Amy M. Hein et al.   BRAIN BEHAVIOR AND IMMUNITY

MAPK, β-amyloid and synaptic dysfunction: the role of RAGE

(2009) Nicola Origlia et al.   Expert Review of Neurotherapeutics

Targeting protein kinases in central nervous system disorders

(2009) Laura K. Chico et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits

(2008) Gonzalo I. Cancino et al.   BRAIN

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

(2008) Maria Buxade   Frontiers in Bioscience-Landmark

Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid- -Mediated Cortical Synaptic Dysfunction

(2008) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease

(2003) Xiongwei Zhu et al.   JOURNAL OF NEUROCHEMISTRY