Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge

(2017) Olga Spadaro et al.   Cell Reports

Longevity is impacted by growth hormone action during early postnatal period

(2017) Liou Y Sun et al.   eLife

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan

(2017) Nicole M. Ashpole et al.   GeroScience

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

(2016) Ying Ann Chiao et al.   Aging-US

The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research

(2016) Sofiya Milman et al.   Cell Metabolism

Sex Differences in Lifespan

(2016) Steven N. Austad et al.   Cell Metabolism

Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice

(2016) Sangmi Ock et al.   ENDOCRINOLOGY

Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females

(2016) Riia K. Junnila et al.   ENDOCRINOLOGY

The somatotropic axis and aging: Benefits of endocrine defects

(2016) Andrzej Bartke et al.   GROWTH HORMONE & IGF RESEARCH

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Quality control systems in cardiac aging

(2015) Ellen K. Quarles et al.   AGEING RESEARCH REVIEWS

Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline

(2015) Derek M. Huffman et al.   AGING CELL

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

The somatotropic axis and longevity in mice

(2015) H. M. Brown-Borg   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin

(2015) Rita Slaaby   Scientific Reports

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

(2014) Sofiya Milman et al.   AGING CELL

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice

(2014) Jose Cordoba-Chacon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Long- But Not Short-Term Adult-Onset, Isolated GH Deficiency in Male Mice Leads to Deterioration of β-Cell Function, Which Cannot Be Accounted for by Changes in β-Cell Mass

(2014) Jose Cordoba-Chacon et al.   ENDOCRINOLOGY

IGF1R blockade with ganitumab results in systemic effects on the GH–IGF axis in mice

(2014) Gordon Moody et al.   JOURNAL OF ENDOCRINOLOGY

Reductions in serum IGF-1 during aging impair health span

(2013) Zhenwei Gong et al.   AGING CELL

Longevity effect of IGF-1R+/−mutation depends on genetic background-specific receptor activation

(2013) Jie Xu et al.   AGING CELL

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

The adverse events profile of anti-IGF-1R monoclonal antibodies in cancer therapy

(2013) Honghai Ma et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Abdominal Obesity, Independent from Caloric Intake, Accounts for the Development of Intestinal Tumors in Apc1638N/+ Female Mice

(2013) D. M. Huffman et al.   Cancer Prevention Research

The GH/IGF-1 axis in ageing and longevity

(2013) Riia K. Junnila et al.   Nature Reviews Endocrinology

Epitope-Specific Mechanisms of IGF1R Inhibition by Ganitumab

(2013) Frank J. Calzone et al.   PLoS One

IGF-IR signaling attenuates the age-related decline of diastolic cardiac function

(2012) Sarah Moellendorf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Phase II Study of Ganitumab, a Fully Human Anti–Type-1 Insulin-Like Growth Factor Receptor Antibody, in Patients With Metastatic Ewing Family Tumors or Desmoplastic Small Round Cell Tumors

(2012) William D. Tap et al.   JOURNAL OF CLINICAL ONCOLOGY

Insulin Resistance and Aging: A Cause or a Protective Response?

(2012) N. Barzilai et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances

(2012) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles

(2011) Cagdas Tazearslan et al.   AGING CELL

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice

(2010) Jacob A. Panici et al.   FASEB JOURNAL

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

(2009) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

(2009) S. E. Lutz et al.   JOURNAL OF NEUROSCIENCE

Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

(2009) Y. Ikeno et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells

(2009) P. J. Beltran et al.   MOLECULAR CANCER THERAPEUTICS

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Effect of exercise and calorie restriction on biomarkers of aging in mice

(2008) Derek M. Huffman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA