Internalization mechanisms of cell-penetrating peptides

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

(2019) Justine Habault et al.   MOLECULES

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide

(2019) Davide Schiroli et al.   Molecular Therapy-Nucleic Acids

Interaction of a Polyarginine Peptide with Membranes of Different Mechanical Properties

(2019) Matías A. Crosio et al.   Biomolecules

Regulation of Clathrin-Mediated Endocytosis

(2018) Marcel Mettlen et al.   Annual Review of Biochemistry

Cellular uptake mechanism and comparative in vitro cytotoxicity studies of monomeric LMWP-siRNA conjugate

(2018) Junxiao Ye et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane remodeling in clathrin-mediated endocytosis

(2018) Volker Haucke et al.   JOURNAL OF CELL SCIENCE

The Future of Bioorthogonal Chemistry

(2018) Neal K. Devaraj   ACS Central Science

Membrane permeation of arginine-rich cell-penetrating peptides independent of transmembrane potential as a function of lipid composition and membrane fluidity

(2017) Rike Wallbrecher et al.   JOURNAL OF CONTROLLED RELEASE

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

(2017) Ikuhiko Nakase et al.   Scientific Reports

Syndecan-4 Is a Receptor for Clathrin-Mediated Endocytosis of Arginine-Rich Cell-Penetrating Peptides

(2016) Yoshimasa Kawaguchi et al.   BIOCONJUGATE CHEMISTRY

Characterization of a Cell-Penetrating Peptide with Potential Anticancer Activity

(2016) Anja Gronewold et al.   ChemMedChem

Cell-penetrating peptides as noninvasive transmembrane vectors for the development of novel multifunctional drug-delivery systems

(2016) Dongdong Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Peptides for Specifically Targeting Nanoparticles to Cellular Organelles: Quo Vadis?

(2015) Lauren D. Field et al.   ACCOUNTS OF CHEMICAL RESEARCH

Delivery of therapeutic oligonucleotides with cell penetrating peptides

(2015) Prisca Boisguérin et al.   ADVANCED DRUG DELIVERY REVIEWS

Cationic PTD/CPP-mediated macromolecular delivery: charging into the cell

(2015) Peter Lönn et al.   Expert Opinion on Drug Delivery

Cell-penetrating peptides as a promising tool for delivery of various molecules into the cells

(2015) Jaroslaw Ruczynski et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

The Effect of a Connexin43-Based Peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial

(2015) Gautam S. Ghatnekar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Computational Investigations of Arginine-Rich Peptides Interacting with Lipid Membranes

(2015) Juan-mei Hu et al.   MACROMOLECULAR THEORY AND SIMULATIONS

Enhanced cellular internalization of CdTe quantum dots mediated by arginine- and tryptophan-rich cell-penetrating peptides as efficient carriers

(2015) Samad Mussa Farkhani et al.   Artificial Cells Nanomedicine and Biotechnology

Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic cell-penetrating peptides

(2015) H.-B. Pang et al.   Science Advances

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα

(2014) Ikuhiko Nakase et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translocation of cell-penetrating peptides across the plasma membrane is controlled by cholesterol and microenvironment created by membranous proteins

(2014) Janely Pae et al.   JOURNAL OF CONTROLLED RELEASE

Cell penetration: scope and limitations by the application of cell-penetrating peptides

(2014) Siegmund Reissmann   JOURNAL OF PEPTIDE SCIENCE

New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids

(2013) Piret Arukuusk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Differential Endosomal Pathways for Radically Modified Peptide Vectors

(2013) Piret Arukuusk et al.   BIOCONJUGATE CHEMISTRY

Identification of cellular proteins interacting with octaarginine (R8) cell-penetrating peptide by photo-crosslinking

(2013) Yoshimasa Kawaguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Cell-penetrating peptides: Achievements and challenges in application for cancer treatment

(2013) Meong Cheol Shin et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery

(2013) Feihu Wang et al.   JOURNAL OF CONTROLLED RELEASE

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

CXCR4 Stimulates Macropinocytosis: Implications for Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and HIV

(2012) Gen Tanaka et al.   CHEMISTRY & BIOLOGY

Cell entry of cell penetrating peptides: tales of tails wagging dogs

(2012) Arwyn T. Jones et al.   JOURNAL OF CONTROLLED RELEASE

PepFect14 Peptide Vector for Efficient Gene Delivery in Cell Cultures

(2012) Kadi-Liis Veiman et al.   MOLECULAR PHARMACEUTICS

Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells

(2012) Hisaaki Hirose et al.   MOLECULAR THERAPY

Translocation of polyarginines and conjugated nanoparticles across asymmetric membranes

(2012) Zhen-lu Li et al.   Soft Matter

Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

(2011) Ikuhiko Nakase et al.   ACCOUNTS OF CHEMICAL RESEARCH

Analyzing Nanomaterial Bioconjugates: A Review of Current and Emerging Purification and Characterization Techniques

(2011) Kim E. Sapsford et al.   ANALYTICAL CHEMISTRY

A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt

(2011) Rajeshwari R. Mehta et al.   ANGIOGENESIS

Cell-Penetrating Peptides, PepFects, Show No Evidence of Toxicity and ImmunogenicityIn VitroandIn Vivo

(2011) Julia Suhorutsenko et al.   BIOCONJUGATE CHEMISTRY

Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides

(2011) Kariem Ezzat et al.   FASEB JOURNAL

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Uptake mechanisms of non-viral gene delivery

(2011) Shengnan Xiang et al.   JOURNAL OF CONTROLLED RELEASE

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials

(2011) Feng Zhao et al.   Small

Cell biology meets biophysics to unveil the different mechanisms of penetratin internalization in cells

(2010) Isabel D. Alves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Different membrane behaviour and cellular uptake of three basic arginine-rich peptides

(2010) Astrid Walrant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cell-Penetrating Peptide Induces Leaky Fusion of Liposomes Containing Late Endosome-Specific Anionic Lipid

(2010) Sung-Tae Yang et al.   BIOPHYSICAL JOURNAL

Strategies for the intracellular delivery of nanoparticles

(2010) Leo Y. T. Chou et al.   CHEMICAL SOCIETY REVIEWS

Distinct Behaviour of the Homeodomain Derived Cell Penetrating Peptide Penetratin in Interaction with Different Phospholipids

(2010) Ofelia Maniti et al.   PLoS One

Learning from the Viral Journey: How to Enter Cells and How to Overcome Intracellular Barriers to Reach the Nucleus

(2009) Diky Mudhakir et al.   AAPS Journal

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

(2009) Ayman El-Sayed et al.   AAPS Journal

Protein Delivery with Transportans Is Mediated by Caveolae Rather Than Flotillin-Dependent Pathways

(2009) Pille Säälik et al.   BIOCONJUGATE CHEMISTRY

Alternative Mechanisms for the Interaction of the Cell-Penetrating Peptides Penetratin and the TAT Peptide with Lipid Bilayers

(2009) Semen Yesylevskyy et al.   BIOPHYSICAL JOURNAL

Arginine-Rich Peptides Destabilize the Plasma Membrane, Consistent with a Pore Formation Translocation Mechanism of Cell-Penetrating Peptides

(2009) H.D. Herce et al.   BIOPHYSICAL JOURNAL

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

(2009) Frederic Heitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Noncationic Peptides Obtained From Azurin Preferentially Enter Cancer Cells

(2009) B. N. Taylor et al.   CANCER RESEARCH

Arginine-rich cell-penetrating peptides

(2009) Nathan Schmidt et al.   FEBS LETTERS

Endocytosisviacaveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation?

(2009) Anna L. Kiss et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis

(2009) Ikuhiko Nakase et al.   MOLECULAR THERAPY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding

(2009) Gautam S Ghatnekar et al.   Regenerative Medicine

Comparison of Cellular Uptake Using 22 CPPs in 4 Different Cell Lines

(2008) Judith Mueller et al.   BIOCONJUGATE CHEMISTRY

An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection

(2008) Seong Loong Lo et al.   BIOMATERIALS

Cell Entry of Arginine-rich Peptides Is Independent of Endocytosis

(2008) Gohar Ter-Avetisyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proline-rich, amphipathic cell-penetrating peptides

(2007) Sílvia Pujals et al.   ADVANCED DRUG DELIVERY REVIEWS

Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides

(2007) Bryan R. Meade et al.   ADVANCED DRUG DELIVERY REVIEWS

Live-cell analysis of cell penetration ability and toxicity of oligo-arginines

(2007) Gisela Tünnemann et al.   JOURNAL OF PEPTIDE SCIENCE