A Mitochondrial Encoded Messenger at the Nucleus

Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells

(2018) Qingqing Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

(2018) Kyung Hwa Kim et al.   Cell Metabolism

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance

(2018) Caiqi Du et al.   PEDIATRIC DIABETES

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

(2018) Valentina Celestini et al.   Cell Death & Disease

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Mitochondrially derived peptides as novel regulators of metabolism

(2017) Su-Jeong Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

Peptides as Quorum Sensing Molecules: Measurement Techniques and Obtained Levels In vitro and In vivo

(2017) Frederick Verbeke et al.   Frontiers in Neuroscience

The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity

(2017) Alan K. Okada et al.   Scientific Reports

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

(2016) Laura J. Cobb et al.   Aging-US

Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation

(2016) Wei Ming et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction

(2016) Savitree Thummasorn et al.   Cardiovascular Therapeutics

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

The changing view of eukaryogenesis – fossils, cells, lineages and how they all come together

(2016) Joel B. Dacks et al.   JOURNAL OF CELL SCIENCE

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

(2016) Su-Jeong Kim et al.   Oncotarget

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

(2015) Noriyuki Fuku et al.   AGING CELL

Central effects of humanin on hepatic triglyceride secretion

(2015) Zhenwei Gong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance

(2015) Kim Zarse et al.   Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity

(2015) Richard M. Monaghan et al.   NATURE CELL BIOLOGY

Mitochondrial Proteins Moonlighting in the Nucleus

(2015) Richard M. Monaghan et al.   TRENDS IN BIOCHEMICAL SCIENCES

The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling

(2014) Yun Chau Long et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of mitochondria in mTOR-regulated longevity

(2014) Yuehua Wei et al.   BIOLOGICAL REVIEWS

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Outfielders Playing in the Infield: Functions of Aging-Associated "Nuclear" Proteins in the Mitochondria

(2014) P. Czypiorski et al.   CURRENT MOLECULAR MEDICINE

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell

(2013) Regina Kuliawat et al.   FASEB JOURNAL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription

(2011) Fu-Yu Chueh et al.   CELLULAR SIGNALLING

Humanin Protects Cortical Neurons from Ischemia and Reperfusion Injury by the Increased Activity of Superoxide Dismutase

(2011) Shen-Ting Zhao et al.   NEUROCHEMICAL RESEARCH

Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

(2010) Radhika H. Muzumdar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

(2010) Ohad Yogev et al.   PLOS BIOLOGY

Evidence for potential functionality of nuclearly-encoded humanin isoforms

(2009) Marek Bodzioch et al.   GENOMICS

Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130

(2009) Yuichi Hashimoto et al.   MOLECULAR BIOLOGY OF THE CELL